Leukotriene receptor antagonists toxicity

Treatment with a leukotriene-receptor antagonist, particularly montelukast, is widely prescribed, especially by primary care providers. Taken orally, leukotriene-receptor antagonists are easy to use and appear to be used more regularly than inhaled corticosteroids. They are rarely associated with troublesome side effects. Maintenance therapy with a leukotriene antagonist or with cromolyn or nedocromil appears to be roughly as effective as maintenance therapy with theophylline. Because of concerns over the possible long-term toxicity of systemic absorption of inhaled corticosteroids, this maintenance therapy is widely used for treating children in the USA. 

THEOPHYLLINE LEUKOTRIENE RECEPTOR ANTAGONISTS -ZAFIRLUKAST Possibly t theophylline levels. Also possibly 4 zafirlukast levels Mutual alteration of metabolism Be aware watch for features of theophylline toxicity and measure levels... 

Montelukast 7 is an orally active selective leukotriene receptor antagonist used for the treatment of asthma. With an annual volume of approximately 20 metric tons per year and a synthetic route that requires both large amount of solvents and a toxic, difficult-to-handle chiral reducing agent, montelukast represented an attractive target for biocatalysis as a way to implement a greener, more efficient process. 

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