Leukotrienes LTC4 type

The cellular locations of leukotriene biosynthesis are determined by the distribution and location of the enzymes needed for their production. 5-Lipoxygenase is found in only a limited number of specific cell types, predominantly of myeloid extraction. Because of this restricted expression, production of LTA4 is largely limited to those cells (e.g., basophils, eosinophils, neutrophils, macrophages, mast cells, and monocytes) (66). These cells produce LTA4, further process it to either LTB4 or LTC4, or secrete it. 

The mechanism of action of the leukotrienes is unknown at present. Nevertheless, we do know that the compounds bind to receptors on the surface of target cells. These receptors show specificity for different types of leukotrienes, e.g. LTD4 but not LTC4. 

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