SEARCH Articles Figures Tables Application During Lead Optimization Aqueous lead optimization Bioisosterism lead optimization CHEMOINFORMATICS IN LEAD OPTIMIZATION Chemical arrays, lead optimization Decision analysis techniques, lead optimization Drug design lead optimization Drug design structure-assisted lead optimization Drug discovery lead optimization phase Drug discovery stages late stage lead optimization Drug discovery stages lead optimization Early Optimization or Hit-to-Lead Libraries Efficient Strategies for Lead Optimization by Simultaneously Addressing Affinity, Selectivity and Pharmacokinetic Parameters Factorial design, lead optimization Force fields structure-based lead optimization Genetic algorithms lead optimization Hit-to-lead optimization Implementing Lead Optimization Strategies for Small Molecules In Silico Lead Optimization Integration of Lead Optimization Data for Candidate Selection and Development Kinase lead optimization Knowing Inhibition Modality Is Important for Structure-Based Lead Optimization Lead Finding and Optimization Lead Optimization and Candidate Selection Lead generation, optimization Lead optimization Hansch analysis Lead optimization QSAR) Lead optimization activity cliffs Lead optimization antitarget activity Lead optimization application Lead optimization approaches Lead optimization basic rules Lead optimization chemoinformatics Lead optimization data analysis techniques Lead optimization desirability functions Lead optimization drug metabolism environment Lead optimization exploration Lead optimization filters Lead optimization functional group replacements Lead optimization isosteres Lead optimization matched molecular pairs Lead optimization molecular scaffolds Lead optimization overview Lead optimization peptidomimetics Lead optimization pharmaceutical industry applications Lead optimization pharmacophore determination Lead optimization phase Lead optimization process Lead optimization property profile Lead optimization quantification Lead optimization quantitative structure-activity relationships Lead optimization retrospective analyses Lead optimization setting Lead optimization similarity principle Lead optimization structure—activity relationships Lead optimization transfer mechanisms Lead optimization, catalyst combinatorial Lead optimization, catalyst combinatorial chemistry Lead optimization, drug discovery Lead optimization, integrated Lead optimization, integrated approaches Lead optimization, integrated approaches consideration Lead optimization, integrated index Lead structure optimization Multi-property lead optimization Multidimensional lead optimization Multiparameter optimization , lead Multiplicative methods, lead optimization Optimization of a lead Optimization of lead compound Optimization of the Lead Structure Optimizing the Lead Compound Pharmacokinetic and Pharmaceutical Phases Optimizing the Selectivity of Nonselective Lead Structures Pharmaceutical chemicals structure-based lead optimization Preclinical lead optimization Preclinical lead optimization Preparative Preclinical lead optimization technologies Preclinical lead optimization technologies screens Profiling lead optimization Protein crystallography lead optimization Results Do Lead Optimization Teams Get What They Need Small-Molecule Safety Lead Optimization Structure-assisted lead optimization Structure-based lead optimization Structure-based lead optimization application to specific targets Structure-based lead optimization discovery Structure-based lead optimization fragment positioning Structure-based lead optimization high-throughput screening Structure-based lead optimization library enumeration Structure-based lead optimization modification Structure-based lead optimization molecular simulation Structure-based lead optimization virtual screening