Lead optimization antitarget activity

In the search for an optimal lead compound, not only activity on the desired target but also activity on other targets should be considered. Sometimes, multi-protein-targeting is desired, e.g., for multi-kinase inhibitors in the oncology field. However, also activity on side effect-related targets - so-called antitargets -is to be investigated. Compounds with no or very low affinity to proteins related to cardiovascular, cytotoxic, or metabolic effects are more likely to pass... 

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