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Preclinical lead optimization technologies

These preclinical lead optimization technologies (PLOT S), must be sufficiently rapid to interface with high-throughput screens without creating a further pipeline bottleneck, be predictive of drug failure, and... [Pg.2192]

The incredible advances in discovery technology and lead optimization over the past few years have enabled the industry to generate more compounds than ever to be tested in clinical investigations. " With this rush of new compounds for evaluation, PK/PD modeling and simulation touch various aspects of the preclinical phase of drug development. [Pg.2808]


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Preclinical lead optimization

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