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Small-Molecule Safety Lead Optimization

1 BACKGROUND AND OBJECTIVES OF SAFETY LEAD OPTIMIZATION APPROACHES [Pg.15]

Drug Discovery Toxicology From Target Assessment to Translational Biomarkers, First Edition. Edited by Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, and Brandon D. Jelly. [Pg.15]

Regardless of the molecular platform, the overall goals of safety lead optimization are as follows  [Pg.16]

This chapter will describe safety lead optimization strategic approaches for small molecules, including commonly used tools and data integration approaches to inform decision-making. [Pg.16]


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Lead optimization

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