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Lead optimization pharmacophore determination

The pharmacophore concept plays a very important role in guiding the drug discovery process. Pharmacophore models help medicinal chemists gain an insight into the key interactions between ligand and receptor when the receptor structure has not been determined experimentally. A pharmacophore can be used as a basis for the alignment rules in 3D-QSAR analysis for the lead compound optimization... [Pg.60]

See other pages where Lead optimization pharmacophore determination is mentioned: [Pg.162]    [Pg.71]    [Pg.273]    [Pg.294]    [Pg.151]    [Pg.73]    [Pg.41]    [Pg.168]    [Pg.2]    [Pg.73]    [Pg.185]    [Pg.190]    [Pg.218]    [Pg.514]    [Pg.48]    [Pg.257]    [Pg.124]    [Pg.221]    [Pg.3]    [Pg.182]    [Pg.192]   
See also in sourсe #XX -- [ Pg.273 , Pg.274 ]



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