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Lead optimization transfer mechanisms

Fig. 7 Antagonistic center/surround interaction is the basic model of a foveal retinal ganglion cell receptive field. Note that the center mechanism is characterized by a narrow and tall response (sensitivity) profile, whereas the surround is broad and has a low, spatially extended profile. The response profiles are established by preganghonic circuitry. The ganglion cell performs the linear operation of subtracting the center and surround signals. If the surround mechanism is selectively attenuated it may lead to a response that monotonically grows with center stimulation. As a result the spatial transfer function loses tuning. The exact spatial frequency at which tuning occurs reflects on the diameter and optimal interplay between center and surround (after Enroth-CugeU and Robson, 1966)... Fig. 7 Antagonistic center/surround interaction is the basic model of a foveal retinal ganglion cell receptive field. Note that the center mechanism is characterized by a narrow and tall response (sensitivity) profile, whereas the surround is broad and has a low, spatially extended profile. The response profiles are established by preganghonic circuitry. The ganglion cell performs the linear operation of subtracting the center and surround signals. If the surround mechanism is selectively attenuated it may lead to a response that monotonically grows with center stimulation. As a result the spatial transfer function loses tuning. The exact spatial frequency at which tuning occurs reflects on the diameter and optimal interplay between center and surround (after Enroth-CugeU and Robson, 1966)...
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