Irritation to the skin and eyes

Bromothiophenes are toxic materials by aU routes. Inhalation toxicity of 2-bromothiophene is significant. Ecotoxicity is also noted for these materials, particularly for 2-bromo-3-methylthiophene. 2-Thiophenecarboxaldehyde and the 3-methyl derivative can cause minor irritation to the skin and eyes of rabbits. The former is a sensitizer to guinea pig skin, the latter is not. 2-Acetylthiophene is toxic in aU modes of contact. Severe exposure causes serious inflammation of the lung, damage to many organs, and depression of the central nervous system. 

It is important to stress that neither sodium silicate nor silico fluoride will improve the performance of a poor, low-strength, dusty concrete floor and if the surface is too porous, there is no way that all the material applied can react with the relatively small quantity of free lime in the concrete surface. All that will happen is that the pores will be filled with non-reacted powder, producing a most unpleasant alkaline dust, which can be very irritating to the skin and eyes when the floor is put into service. 

Dermal/Ocular Effects. Bromomethane vapor is irritating to the skin and eyes, and humans who are exposed to bromomethane in air may experience conjunctivitis, erythema, rashes, or even blisters... 

Toxicology. Chlorothalonil is an irritant to the skin and eyes and has been reported to produce allergic contact dermatitis in exposed workers. 

The lowest LDso reported for q clohex-imide is 2mg/kg after oral administration in the rat. In animal experiments, cycloheximide is irritating to the skin and eyes. Animals given toxic doses exhibit salivation, bloody diarrhea, tremors, and excitement leading to death from cardiovascular collapse. ... 

Toxicology. Ethyl butyl ketone (EBK) is mildly irritating to the skin and eyes of animals and causes narcosis at high concentrations. 

Ethylene is not irritating to the skin and eyes. The gas has a faintly sweet odor that probably does not provide adequate warning of hazardous concentrations. Owing to the highly flammable and explosive characteristics of ethylene, it should be handled cautiously. ... 

Toxicology. 2,4-Pentanedione is moderately irritating to the skin and eyes repeated exposure to high concentrations causes dyspnea, central nervous system damage, and death. 

Some quaternary ammonium compounds arc potent germicides, toxic in small (mg/L range) quantities to a wide range of microorganisms. Bactericidal, algicidal, and fungicidal properties are exhibited, Many quaternaries are considered to be moderately to severely irritating to the skin and eyes. 

Mild irritant to the skin and eyes.1 LD50 (oral rat) 3800 mg/kg. LD50 (dermal rabbit) above 2000 mg/kg.2 LC50 (rainbow trout, 48 hours) 5.4 pg/L.3... 

Hydrogen bromide, HBr (mp, -87°C bp, -66.5°C), and hydrogen iodide, HI (mp, -50.8°C bp, -35.4°C), are both pale yellow or colorless gases, although contamination by their respective elements tends to impart some color to these compounds. Both are very dense gases, 3.5 g/1 for HBr and 5.7 g/1 for HI at 0°C and atmospheric pressure. These compounds are used much less than HC1. Both are irritants to the skin and eyes and to the oral and respiratory mucous membranes. 

Toxicity The acute oral LD50 to rats is 3,300 mg/kg, whereas the acute dermal LD50 to rabbits is 4,000 mg/kg. Butachlor is a mild irritant to the skin and eyes of rabbits. 

Toxicity Bendiocarb is moderately toxic if it is ingested or absorbed through the skin. Skin absorption is the most likely route of exposure. It is a mild irritant to the skin and eyes.4 Like other carbamate insecticides, bendiocarb is a reversible inhibitor of cholinesterase, an essential nervous system enzyme. Symptoms of bendiocarb poisoning include weakness, blurred vision, headache, nausea, abdominal cramps, chest discomfort, constriction of pupils, sweating, muscle tremors, and decreased pulse. 

The toxicity of aliphatic diisocyanates also warrants monitoring exposure to its vapors. HDI has a moderate potential for acute systemic dermal toxicity rabbit dermal LD50 is 570 ml/Kg (57). However, HDI is severely irritating to the skin and eyes. Irritation, lacrimation, rhinitis, burning sensation to throat and chest, and coughing have all been reported in humans following acute inhalation exposure to HDI. HMDI has a low eye and dermal irritation potential, as well as a low potential for acute toxicity. Exposure to HMDI aerosol can cause dermal sensitization of laboratory animals. IPDI can cause skin sensitization reactions as well as eye irritation. The acute toxicity of diisocyanates in rats is shown in Table 12. 

Some materials involved in the epoxy adhesive formulations are more dangerous than others, and some affect certain parts of the body whereas others do not. Amine curing agents, for example, are generally the most irritating to the skin and eyes. They may also be considered to be strong caustics, and they produce serious local injury on short exposure. If they are worked in a hot condition, their fumes pose additional hazards. 

GENERAL When undiluted and not properly handled, can be irritating to the skin and eyes and upon inhalation. Combustible material that can sustain a fire. 

Sodium azide is very toxic by ingestion and inhalation. Contact with acids liberates a highly toxic gas. It is also irritating to the skin and eyes. It reacts slowly with water at ambient temperatures but decomposes violently in hot water. It forms readity detonatable salts with many metals. 

Observe normal precautions appropriate to the circumstances and quantity of material handled. Bronopol may be harmful upon inhalation and the solid or concentrated solutions can be irritant to the skin and eyes. Eye protection, gloves, and dust respirator are recommended. Bronopol burns to produce toxic fumes. 

Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic. 

Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye. Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents. 

A short-term feeding study in chickens with a diet supplemented with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content. Sodium acetate is poisonous if injected intravenously, is moderately toxic by ingestion, and is an irritant to the skin and eyes. ... 

Acetamide may be inhaled, swallowed, or absorbed through the skin. The chemical is considered to be mildly irritating to the skin and eyes. In its usual application, inhalation is the most common route of exposure, although dermal contact is always possible. 

Cresols are highly irritating to the skin and eyes of rabbits, rats, and mice. Short-term exposure to inhaled mixtures of cresol aerosol and vapor results in irritation of the respiratory tract, small hemorrhages in the lung, body weight reduction, degeneration of heart muscle, liver, kidney, and nerve cells. 

Dimethyl sulfide can be either a liquid or vapor by itself or in combination with other materials that can come into contact with the skin or be inhaled. It can be irritating to the skin and eyes. Based on single exposure animal tests, dimethyl sulfide is considered moderately toxic if swallowed, slightly toxic if absorbed through the skin, and slightly toxic if inhaled. The compound has a strong, objectionable odor that can cause nausea, dizziness, or headache. 

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