Ocular effect

Quetiapine was associated with cataracts in preclinical safety studies conducted in beagles. Subsequent studies involving nonhuman primates did not detect an increased risk of cataracts also, postmarketing surveys have not detected an increased risk of cataracts in patients taking quetiapine compared with patients taking other antipsychotics. 

Patients taking antipsychotics, especially the ahphatic phenothi-azines (e.g., chlorpromazine), may become more sensitive to sun-hght, which can lead to severe sunburn. 

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Ocular Effects. Pinpoint pupils (miosis) have been observed in individuals following acute exposure to methyl parathion. Electroretinographic changes have been reported in mice following intraperitoneal injection of 1.5 mg of methyl parathion. These changes were a direct effect of methyl parathion on... 

Ocular Effects. One study reported that seven children exposed to methyl parathion by inhalation, oral, and possibly dermal routes exhibited pinpoint pupils (miosis) (Dean et al. 1984). This effect is a consequence of the effects on the autonomic nervous system. No other studies were located regarding ocular effects in humans or animals after inhalation exposure to methyl parathion. 

Ocular Effects. No studies were located regarding ocular effects in humans after inhalation exposure to endosulfan. Routine gross and histopathologic examination of the eyes did not reveal any effects of nose-only exposure of rats to concentrations of endosulfan of up to 2 mg/m for 6 hours/day, 5 days/week for a total of 21 out of 29 days (Hoechst 1984c). 

Ocular Effects. No studies were located regarding ocular effects in humans following oral exposure to endosulfan. 

Anand et al. 1987). The authors hypothesized that the ocular effects associated with endosulfan may be a result of prolonged hypertension (although no data on blood pressure were presented, and there is no other information to indicate that chronically administered endosulfan induces hypertension) or an endosulfan-induced vitamin A deficiency (which was observed in this study). Although the rabbit may represent a uniquely sensitive species, the possibility that long-term exposure of persons at hazardous waste sites to endosulfan may result in adverse effects on ocular tissues cannot be eliminated. 

Ocular Effects. Humans that were experimentally exposed to 200 ppm of trichloroethylene vapor for 7 hours experienced mild eye irritation (20% of the subjects), beginning after 30 minutes (Stewart et al. 1970). The subjects experiencing these symptoms did not again experience them when exposed in the same manner on 5 other consecutive days. Itchy watery eyes (Bauer and Rabens 1974 El Ghawabi et al. 1973) and inflamed eyes (Schattner and Malnick 1990) have also been reported following contact with the vapor. 

No studies were located regarding respiratory, cardiovascular, gastrointestinal, hematological, musculoskeletal, renal, or ocular effects in humans or animals after dermal exposure to trichloroethylene. 

Although these studies were designed to look for ocular effects, no adverse effects of these xanthophylls were reported where clinical or biochemical parameters were also examined. 

A 52-week study in monkeys was designed to evaluate ocular effects. Despite the absence of adverse toxicological effects at the highest dose tested (20 mg/kg body weight per day), the study was considered inappropriate for the establishment of an ADI in view of the much higher doses used in several other studies and found to be without effects. The available comparative toxicokinetic data for humans and rats indicated that studies of toxicity in rats could be used to derive an ADI. 

Loerzel S, Samuelson D, Szabo N. 1999. Ocular effects methyhnercury toxicity in juvenile double-crested cormonants (Phalacrocorax auritus). Investigative Ophthalmology Visual Science. Annual meeting of the Association for Research in Vision and Ophthalmology. Fort Lauderdale, FL, May 9-14, 1999. 

Ocular effects include conjunctival reddening, a slight miosis, and decreased intraocular pressure Cardiovascular tachycardia and vasodilation combined with orthostatic hypotension in high doses... 

No data were located regarding gastrointestinal effects, endocrine effects, dermal effects, or ocular effects in humans or animals following acute-, intermediate-, or chronic-duration inhalation exposure to americium. 

No data were located regarding systemic effects in humans following acute-, intermediate-, or chronic-duration exposure to americium by routes other than inhalation, oral, dermal, or external exposure. No data were located regarding respiratory effects, cardiovascular effects, gastrointestinal effects, renal effects, dermal effects, ocular effects, or metabolic effects animals following exposure to americium by routes other than inhalation, oral, dermal, or external exposure. 

Organophosphate Ester Hydraulic Fluids. No studies regarding ocular effects in humans after inhalation or oral exposure were located. 

No studies were located regarding respiratory, cardiovascular, gastrointestinal, hematological, musculoskeletal, hepatic, renal, dermal, or ocular effects in humans or animals after dermal exposure to hydrogen sulfide. However, several sources indicate that care must be taken with liquefied hydrogen sulfide in order to avoid frostbite (ATSDR 1994 NIOSH 1997). 

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