Hypercalcemia constipation

Drug may produce same signs of renal damage as severe acute lead poisoning (proteinuria, microscopic hematuria). Transient anemia/bone marrow depression, hypercalcemia (constipation, drowsiness, dry mouth, metallic taste) occurs occasionally. 

Contact the primary health care provider if the following occur nausea, vomiting, anorexia, constipation, abdominal pain, dry mouth, thirst, or polyuria (symptoms of hypercalcemia). 

Adverse effects of calcium-containing phosphate binders, as well as sevel-amer and lanthanum, include constipation, diarrhea, nausea, vomiting, and abdominal pain. The risk of hypercalcemia is also a concern. To avoid potential drug interactions, phosphate binders should be administered 1 hour before or 3 hours after other oral medications. 

Hypercalcemia of malignancy develops quickly and is associated with anorexia, nausea and vomiting, constipation, polyuria, polydipsia, and nocturia. Hypercalcemic crisis is characterized by acute elevation of serum calcium to greater than 15 mg/dL, acute renal failure, and obtundation. Untreated hypercalcemic crisis can progress to oliguric renal failure, coma, and life-threatening ventricular arrhythmias. 

Hypercalcemia Hypercalcemia may occur when large doses of calcium are administered to patients with chronic renal failure. Mild hypercalcemia may exhibit as nausea, vomiting, anorexia, or constipation, with mental changes such as stupor, delirium, coma, or confusion. 

Ora/ - May cause constipation and headache. Mild hypercalcemia (Ca" " greater than 10.5 mg/dL) may be asymptomatic or manifest itself as Anorexia, nausea, and vomiting. More severe hypercalcemia (Ca 12 mg/dL) is associated with confusion. 

Calcium Acetate (PhosLo) [Calcium Supplement/ Anti arrhythmic/Mmeral/ Electrolyte] Uses ESRD-associated hyper-phos-phatemia Action Ca " supl w/o aluminum to X P04 absorption Dose 2-4 tabs PO w/ meals Caution [C, ] Contra t Ca Disp Gelcap SE Can t Ca, hypophosphatemia, constipation Interactions t Effects OF quinidine X effects W/ large intake of dietary fiber, spinach, rhubarb X effects OF atenolol, CCB, etidronate, tetracyclines, fluoroquinolones, phenytoin, Fe salts, thyroid hormones EMS Pts have reduced renal Fxn, monitor ECG for signs of electrolyte disturbances OD S/Sxs of hypercalcemia (confusion, weakness, GI upset, constipation, N, V, and cardiac arrhythmias) give IV fluid for diuresis symptomatic and supportive Calcium Carbonate (TumS/ Alka Mints) [Antacid/ Calcium Supplement/Mineral/ Electrolyte] [OTC] Uses Hyperacidity associated w/ peptic ulcer Dz, hiatal hernia, etc Action Neutralizes gastric acid Dose 500 mg—2 g PO PRN -1- in renal impair Caution [C, ] Disp Chew tabs, susp SE t -1- PO constipation Interactions X Effect OF tetracyclines, fluo-... 

Rx prevent Ca deficiency Action Ca supl Dose Adul. 6—18 g/d doses Feds. 600-2000 mg/kg/d qid (9 d max) X in renal impair Caution [C, ] Contra T Ca Disp Syrup SE f O a, X PCO constipation. Interactions T Effects OF quinidine X effect OF tetracyclines X Ca absorption w/ high intake OF dietary fiber EMS Monitor ECG for signs of electrol5rte disturbances (T Ca % X Mg ) OD S/Sxs of hypercalcemia weakness, GI upset, and cardiac arrhythmias give IV fluid symptomatic and supportive... 

A variety of adverse effects have been reported following the use of antacids. If sodium bicarbonate is absorbed, it can cause systemic alkalization and sodium overload. Calcium carbonate may induce hypercalcemia and a rebound increase in gastric secretion secondary to the elevation in circulating calcium levels. Magnesium hydroxide may produce osmotic diarrhea, and the excessive absorption of Mg++ in patients with renal failure may result in central nervous system toxicity. Aluminum hydroxide is associated with constipation serum phosphate levels also may become depressed because of phosphate binding within the gut. The use of antacids in general may interfere with the absorption of a number of antibiotics and other medications. 

Hypercalcemia, headache, irritability, constipation, metallic taste, nausea, polyuria Serious Reactions... 

Hypercalcemia is a serious adverse effect of calcium acetate use. Early signs include constipation, headache, dry mouth, increased thirst, irritability, decreased appetite, metallic taste, fatigue, weakness, and depression. Later signs include confusion, somnolence, hypertension, photosensitivity, arrhythmias, nausea, vomiting, and increased painful urination. 

Assess the patient for signs and symptoms of hypercalcemia, including constipation, deep bone or flank pain, excessive thirst, hypotonicity of muscles, increased urine output, nausea and vomiting, and renal calculi... 

Notifyproviderof nausea, vomiting, constipation, lethargy, muscle weakness (possible hypercalcemia)... 

Clearly, the dosage of a calcium supplement must be determined by the specific needs of each individual. Excessive doses must also be avoided because they may produce symptoms of hypercalcemia, including constipation, drowsiness, fatigue, and headache. As hypercalcemia becomes more pronounced, confusion, irritability, cardiac arrhythmias, hypertension, nausea and vomiting, skin rashes, and pain in bones and muscle may occur. Hypercalcemia is a cause for concern because severe cardiac irregularities may prove fatal. 

Vitamin D is a fat-soluble vitamin, and excessive doses can accumulate in the body, leading to toxicity. Some early signs of vitamin D toxicity include headache, increased thirst, decreased appetite, metallic taste, fatigue, and gastrointestinal disturbances (nausea, vomiting, constipation, or diarrhea). Increased vitamin D toxicity is associated with hypercalcemia, high blood pressure, cardiac arrhythmias, renal failure, mood changes, and seizures. Vitamin D toxicity is a serious problem that can cause death because of cardiac and renal failure. 

Calcium carbonate is mainly used in oral pharmaceutical formulations and is generally regarded as a nontoxic material. However, calcium carbonate administered orally may cause constipation and flatulence. Consumption of large quantities (4—60g daily) may also result in hypercalcemia or renal impairment. Therapeutically, oral doses of up to about 1.5 g are employed as an antacid. In the treatment of hyperphosphatemia in patients with chronic renal failure, oral daily doses of 2.5-17 g have been used. Calcium carbonate may interfere with the absorption of other drugs from the gastrointestinal tract if administered concomitantly. 

Symptoms include fatigue, weakness, anorexia, depression, anxiety, cognitive dysfunction, vague abdominal pain, and constipation. Renal symptoms can include polyuria, polydipsia, and nocturia. The extent of symptoms is related to both the degree of hypercalcemia and the rate of onset of the elevation in the serum calcium concentration. Rarely, severe hypercalcemia leads to acute pancreatitis. 

HYPERCALCEMIA The degree and rapidity of onset of hypercalcemia largely dictate the extent of symptoms. Chronic elevation of serum Ca to 12-14 mg/dL (3-3.5 mM) generally causes few manifestations, whereas an acute rise to the same level may cause marked neuromuscular manifestations by increasing the threshold for nerve and muscle excitation. Symptoms include fatigue, weakness, anorexia, depression, diffuse abdominal pain, and constipation. 

Aiuminum Salts Neutralize gastric add. Thus, mucosal irritation is reduced. Pain relief precedes healing. Symptomatic relief of gastric add irritation. Constipation, hypercalcemia, hypophosphatemia. 

Caicium Carbonate (1 Constipation, hypercalcemia, metabolic alMosis, hemorrhoids, bleeding anal fissures. Rarely, milk-alkali syndrome (if taken chronically with milk or bicarbonate). 

The gastrointestinal manifestations of hypercalcemia include abdominal discomfort as a result of peptic ulceration or pancreatitis, pancreatic calcification, vomiting, anorexia, constipation and weight loss. 

Prophylaxis of rickets Hypoparathyroidism Adult osteomalacia Acute Anorexia, nausea, vomiting, diarrhea, headache, polyuria, polydipsia. Chronic Weight loss, pallor constipation, fever, hypercalcemia, calcium deposits in soft tissues. ... 

Toxicity—Excessive vitamin D may cause hypercalcemia lincraasad intestinal absorption, leading to elevated blood calcium levels, characterized by loss ol appetite, excessive thirst, nausea, vomiting, irritability, weakness, constipation alternating with bouts of diarrhea, retarded growth in infants and ciiildrsn, and weight loss in adults. 

---