Appetite, decreased

CRH (Corticotropin releasing hormone) is expressed in the nucleus paraventricularis of the hypothalamus and drives the stress hormone system by activating synthesis and release of corticotropin at the pituitary and in turn corticosteroid from the adrenal cortex. CRH is also expressed at many other brain locations not involved in neuroendocrine regulation, e.g. the prefrontal cortex and the amygdala. Preclinical studies have shown that CRH also coordinates the behavioral adaptation to stress (e.g. anxiety, loss of appetite, decreased sleepiness, autonomic changes, loss of libido). 

Adverse reactions occurring in at least 3% of patients included the following Upper abdominal pain, anxiety, appetite decrease, asthenia, constipation, cough, depression, herpes simplex, influenza, insomnia, myalgia, peripheral neuropathy, pruritus (not otherwise specified), sinusitis, skin papilloma, weight decreased. 

Tablets, injection Depression, swelling of feet, loss of appetite, decreased sexual ability, itching eyes, dizziness, nausea, vomiting, nervousness Transdermal Itching, reddening or darkening of skin Rare (less than 1 %)...

Gastrointestinal system Increased appetite increased frequency of bowel movements hypoproteinemia Decreased appetite decreased frequency of bowel movements ascites... 

Biederman J +, Clin Ther 29(3), 450 (I 2%) Endocrine/Metabolic Appetite decreased... 

Amenorhea Appetite decreased Appetite increased Decreased libido (3%)... 

Abdomen, epigastrium - pain Abdomen, RUQ - pain Abdomen - pain Appetite - decreased (anorexia)... 

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