Drug interaction potential

Pharmacokinetic properties Pharmacodynamic properties Adverse-effect potential Drug-interaction potential Cost... 

Drug Name Generic/(Abbreviation)/ Trade Name Dosage Forms Commonly Prescribed Doses Dose Adjustments Food Restrictions Significant Adverse Events Drug Interaction Potential... 

Determine the drug interaction potential when concurrent medications are administered, as well as food interaction, assess the enzyme induction potential, and assess the need for therapeutic drug monitoring during efficacy testing. 

Rautio, J., Humphreys, J.E., Webster, L. O., Balakrishnan, A., Keogh, J.P., Kunta, J.R., Serabjit-Singh, C.J. and Polli, J.W. (2006) In vitro P-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates a recommendation for probe substrates. Drug Metabolism and Disposition, 34, 786-792. 

Ereshefsky L, Dugan D (2000) Review of the pharmacokinetics, pharmacogenetics, and drug interactions potential of antidepressants focus on venlafaxine. Depress Anxiety 12(Suppl l) 30-44... 

The preparation used in many of the described interactions between St. John s wort and conventional pharmaceutical products is the product manufactured by Lichtwer Pharma GmbH (Berlin, Germany). This product is marketed under the trade name, Jarsin (LI 160) in Germany and marketed in the United States under the trade name Kira . St. John s wort may also be sold in combination products with vitamins and other botanical preparations (32). The drug interaction potential between these combination products and cytochrome P450 (CYP) 3A and P-glycoprotein... 

Anderson GD, Rosito G, Mohustsy MA, Elmer GW. Drug interaction potential of soy extract and Panax ginseng. J Clin Pharmacol 2003 43 643-648. 

Food and Drug Administration Advisory Committee for pharmaceutical sciences and Clinical Pharmacology Subcommittee meeting. Issues and challenges in the evaluation and labeling of drug interaction potentials of NME. Rockville, MD, April 23, 2003 http //www.fda.gov/ohrms/dockets/ac/03/ slides/3947s2.htm http //www.fda.gov/ohrms/dockets/ac/03/transcripts /... 

Blanchard N et al Qualitative and quantitative assessment of drug-drug interaction potential in man, based on Ki, IC50 and inhibitor concentration. Curr Drug Metab 2004 5 147. [PMID 15078192]... 

Omeprazole (Prilosec) was the original PPI this drug is now joined by esomeprazole (Nexium), lansoprazole (Prevacid), pantoprazole (Protonix), and rabeprazole (AcipHex) (see Table 27-2). All of these drugs are similar, with selection often depending on cost, availability, and the drug interaction potential of each agent.15 Likewise, nonprescription forms of certain PPIs are now available, and these forms offer a convenient,... 

M. Salgo, and N. Buss. 2005. Pharmacokinetics, pharmacodynamics and drug interaction potential of enfuvirtide. 

Lane RM. Pharmacokinetic drug-interaction potential of selective serotonin reuptake inhibitors. Int Clin Psychopharmacol 1996 11 31-61. 

Lee SH, Slattery JT (1997) Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver microsomes. Drug Metab Dispos 25 1354-1358 Li AP (1999) Cryopreserved human hepatocytes characterization of DME activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability and drug-drug interaction potential. Chem Biol Interact 121 17-35... 

Li AP, Reith MK, Rasmussen A et al. (1997) In vitro evaluation of drug-drug interaction potential A comparison of rifampin, rifapentine, and rifabutin in cytochrome P450 3A induction potential in primary human hepatocytes. Chemico-Biological Interactions 107 17-30... 

Eap CB, Bondolfi G, Zullino D, Bryois C, Fuciec M, Savary L, Jonzier-Perey M, Baumann P. Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test. Ther Drug Monit 2001 23(3) 228-31. 

A. D. Rodrigues and J. H. Lin, Screening of drug candidates for their drug-drug interaction potential, Curr. Opin. Chem. Biol. 5 (2001), 396. 

Van Cleef GF, Fisher EJ, Polk RE. Drug interaction potential with inhibitors of HIV protease. Pharmacotherapy 1997 42 1553-56. 

Last, PK/PD modeling has been successfully applied in assessing and predicting drug-drug interaction potential as well as formulation developmentJ ... 

Ernst E. Herb-drug interactions potentially important but woefully under-researched. Eur J Clin Pharmacol 2000 56(8) 523. ... 

P450, or inducing specific isoforms of this enzyme system. However, drug interactions involving these isoenzymes and omeprazole or lansoprazole are uncommon and generally appear to be clinically unimportant. Pantoprazole seems to have a lower drug interaction potential than either omeprazole or lansoprazole. 

Mechanism-based approach for the evaluation of drug-drug interaction potential... 

Time-dependent inhibition observed The inhibitor is a time-dependent inhibitor. In vivo studies will need to be performed to further define its drug-drug interaction potential. 

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