Inhibitory activity against human

Diana GD, Otto MJ, Treasurywala AM, et al. Enantiomeric effects of ho-mologues of disoxaril on the inhibitory activity against human rhinivirus-14. J Med Chem 1988 31 540-544. 

Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses. 

LGPS wnan Mum >tCl 5330 IC 90 OS DM 0 In vuo Inhibitory activity against human liver rfymgtn Bhexotorvtife a fHLGPil 0 t... 

Both variolin B and its 5-deoxy derivative 19 (Scheme 6.1 Part 2) have shown promise in pharmacokinetic and in vivo studies. These compounds have been shown to have long terminal half-lives and low normal cell toxicity, however the 5-deoxy derivative demonstrated better Cmax, plasma clearance and terminal plasma half-life.318,319 Both are effective against human lung carcinoma cell lines in nude mice.104 The deoxy-variolin B showed growth inhibitory activity against human leukemic cell lines.105 A standardised method for liquid chromatography-mass spectrometry (LC-MS)/MS analysis of plasma has been developed to monitor the results of the in vivo studies.320... 

Discovery Gerfelin was isolated from culture broth of Beauveria felina QN22047 as a compound showing inhibitory activity against human geranylger-anyl diphosphate (GGPP) synthase [1,2]. The structure was determined as 1 [2]. Methylgerfelin (2) is a synthetic derivative of 1. 

Both Spiro-linked ethers of prorocentin (197) (C/D rings) and okadaic acid (181) (A/B rings) shared the same backbone. Prorocentin (197) exhibited inhibitory activity against human colon adenocarcinoma DLD-1 and human malignant melanoma RPMI7951 with IC50 values of 16.7 and 83.6 pg ml respectively. 

Cidofovir is an antiviral agent that inhibits viral DNA synthesis by interfering with viral DNA polymerase. It is indicated in the treatment of Cytomegalovirus retinitis in patients with AIDS. Cidofovir (l-[(5)-3-hydroxy-2-(phosphonomethoxy)-propyljcytosine dihydrate) is a cytidine nucleotide analog with inhibitory activity against human herpes, papilloma, polyoma, pox, and adenoviruses. 

Quinqueginsin, a homodimeric protein (Mr 53 kDa) with inhibitory activity against human immunodeficiency virus (HIV), fungi, ribonuclease, and cell-free translation. Quinqueginsin has been isolated from the roots of American ginseng Panax quinquefolium. The inhibitory action towards HIV-1 reverse transcriptase was potentiated after chemical modification with succinic anhydride [H. X. Wang, T. B. Ng, Biochem. Biophys. Res. Commun. 2000, 269, 203]. 

We collected a dataset of human aminergic GPCR inhibitors from the GVK database (GVK DB) [11]. The inhibitory activity against human aminergic GPCR was expressed as the logarithm of the reciprocal IC value (pIC ), where IC represents the micromolar concentration at which 50% inhibition is achieved. 

Ursolic acid, taraxasterol, betulinic acid and betulinic aldehyde showed a relative high inhibitory activity against human acyl-CoA cholesterol aeyltransferaze [Lee et al., 2009]. 

Inhibitory activity against human acyl-CoA cholesterol acyltransferaze Lee et al., 2009... 

Kashiwase H, Momota K, Ohmine T, Komai T, Kimura T, Katsube T, Nishigaki T, Kimura S, Shimada K, Furukawa H (1999) A new fluoroquinolone derivative exhibits inhibitory activity against human immunodeficiency virus type 1 replication. Chemotherapy 45 48-55. doi 10.1159/000007164 (1999) Chem Abstr 130 276301... 

The aqueous extracts of U. tomentosa showed the significant inhibitory activity against human leukemia cancer ceU fines (K562 and HL 60) and a human EBV-transformed B l3mphoma ceU line. Literature revealed that the extract of this plant-induced apoptosis, in conjugation with DNA fragmentation, which evidences the antitumor activity [38,37], The aqueous extract of this plant had also been tested for toxicity against Chinese hamster ovary cells, which revealed that it is nontoxic at low concentrations [62],... 

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