Health evaluations

EPA Supefund Public Health Evaluation Manual, EPS /540/1-86 /060, U.S. Environmental Protection Agency, Office of Emergency and Remedial Response, Washington, D.C., October 1986. 

Ethylene oxide has been shown to produce mutagenic and cytogenic effects in a variety of test systems (226). An increased frequency of chromosomal aberrations in peripheral lymphocytes of monkey exposed to ethylene oxide for 104 weeks has been reported (240). In mice, it is an effective inducer of chromosome breaks leading to dominant-lethal mutations. In addition, ethylene oxide has been shown to induce heritable effects in the heritable translocation test conducted in mice exposed to ethylene oxide by inhalation (241,242). In this study, male mice were exposed to ethylene oxide ranging from 165 to 300 ppm for 6 h per day 5 or 7 days/week for 8.5 weeks. Ethylene oxide has also been shown to bind to proteins (243) as well as to DNA (244). Several studies on ethylene oxide-exposed workers have demonstrated an increased incidence of chromosomal aberrations and sister chromatid exchanges the relevance of such effects to human health evaluation is currendy uncertain. 

Boyce, M.P., and Herrera, G., Health Evaluation of Turbine Engines Undergoing Automated FAA Type Cyclic Testing, Presented at the SAE International Ameritech 93, Costa Mesa, California, September 27-30, 1993, SAE Paper No. 932633. 

Coleman PE, Dolinger PM. 1982. Endosulfan monograph number four Environmental health evaluations of California restricted pesticides. Prepared by Peter M. Dolinger Associates, Menlo Park, CA. Sacramento, CA State of California Department of Food and Agriculture. 

EPA (1989) Risk Assessment Guidance for Superfund. Volume I. Human Health Evaluation Manual. EPA/540/1-89/002. 

Patients at greatest risk for mortality from acute pancreatitis are those who have multi-organ failure (e.g., hypotension, respiratory failure, or renal failure), pancreatic necrosis, obesity, volume depletion, greater than 70 years of age, and an elevated APACHE II score.3,4 The Acute Physiology, Age, and Chronic Health Evaluation (APACHE) II score is a rating scale of disease severity in critically ill patients. 

APACHE Acute Physiology, Age, and Chronic Health Evaluation ARDS acute respiratory distress syndrome... 

The outcome from intraabdominal infection is not determined solely by what transpires in the abdomen. Unsatisfactory outcomes in patients with intraabdominal infections may result from complications that arise in other organ systems. A complication commonly associated with mortality after intraabdominal infection is pneumonia.26 A high APACHE (Acute Physiology And Chronic Health Evaluation) II score, a low serum albumin, and a high New York Heart Association cardiac function status were significantly and independently associated with increased mortality from intraabdominal infection.27... 

Activated protein C in patients with severe sepsis and high risk of death (Acute Physiology, Age, and Chronic Health Evaluation II [APACHE II] score greater than 25). 

APACHE II Acute Physiology and Chronic Health Evaluation II a severity of disease classification system using a point score based on initial values of 12 routine physiologic measurements, age, and previous health status used to provide a general measure of disease severity. 

There are various severity of illness scoring systems for sepsis and trauma (R11). Severity scoring can be used, in conjunction with other risk factors, to anticipate and evaluate outcomes, such as hospital mortality rate. The most widely used system is the Acute Physiology, Age, Chronic Health Evaluation II (APACHE II) classification system (K12). The APACHE III was developed to more accurately predict hospital mortality for critically ill hospitalized adults (K13). It provides objective probability estimates for critically ill hospitalized patients treated in intensive care units (ICUs). For critically ill posttrauma patients with sepsis or SIRS, another system for physiologic quantitative classification and severity stratification of the host defense response was described recently (R11). However, this Physiologic State Severity Classification (PSSC) has yet not been applied routinely in ICU setting. 

Ecological information, including information needed for public health evaluation (land use characteristics, water use characteristics) and information needed for environmental evaluation (ecosystem components and characteristics, critical habitats and biocontamination)... 

Harvard School of Public Health, Evaluating the interrelationships between Boston, MA the microbial and metal pollutants in the... 

AMS acute myocardial syndrome ANC absolute neutrophil count ANS autonomic nervous system APACHE Acute Physiologic and Chronic Health Evaluation ICU illness severity scoring system APAP acetaminophen [N-acetyl-p-aminof enol] aPTT activated partial thromboplastin time ARB angiotensin 11 receptor blocker ARDS adult respiratory distress syndrome... 

B. Indications and use Xigrix is indicated for the reduction of mortahty in adult patients with severe sepsis (sepsis associated with acute organ dysfunction) who have a high risk of death [as determined by the acute physiology and chronic health evaluation (APACHE) score, the most widely used method of assessing the severity of illness in acutely ill patients in intensive care units]. 

APACHE Acute physiology and chronic health evaluation... 

Bar, F. Griepentrog, F. (1967) [Health evaluation of food-flavouring agents]. Med. Ernahr, 8, 244-251 (in German)... 

U S Environmental Protection Agency. Risk Assessment Guidance for Superfund (RAGS), Vol. I Human Health Evaluation Manual (Part E, Supplemental Guidancefor Dermal Risk Assessment) Interim, 2004 http //www.epa.gov/oswer/ riskassessment/ragse/index.htm (last accessed 12 July 2010). 

Osterman-Golkar, S., Hussain, S., Walles, S., Anderstam, B. Sigvardsson, K. (1983) Chemical reactivity and mutagenicity of some dihalomethanes. Chem.-biol. Interact., 46, 121-130 Ott, M.G., Skory, L.K., Holder, B.B., Bronson, J.M. Williams, P.R. (1983a) Health evaluation... 

Therefore, before being used for policies and health evaluation, PM air quality models must be evaluated, a process which can now be carried out over long time periods [37, 39] due to the increase in computer power and memory. All models are useful and the choice of an appropriate model is heavily dependent on the intended application the type and dimension of the area, and the final goal of the study (air quality management, exposure and health estimations, etc.). 

Jensen, L.K., Larsen, A., Molhave, L., Hansen, M.K. and Knudsen, B. (2001) Health evaluation of volatile organic compound (VOC) emissions from wood and wood-based materials. Archives of Environmental Health, 56 (5), 419-32. 

Level Concentration Health evaluation Questions for Recommendations... 

Krause, C. and Englert, N. (1980) Health evaluation of pentachlorophenol containing wood preservatives in rooms. Holz als Roh und Werkstojf, 38, 429-32. 

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