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Health threats, evaluation

Skin contact with methanol may present a greater health threat than skin contact with gasoline and diesel fuel and is being evaluated. [Pg.434]

The mere presence of any single chemical or chemical mixture in the environment does not indicate that a health threat exists. An important step of mixture risk assessment is the evaluation of completed exposure pathways. Completed exposure pathways link together the source of contamination, environmental medium, point of exposure, route of exposure, and a receptor population. It means that without the potential for chemicals actually entering (or contacting) the human body, no threat is present. [Pg.24]

The uptake of metals from agricultural soil by crops and vegetables is an important pathway through which metals in contaminated soils impose health threats to organisms. On the other hand, the capacity of plant roots to remove heavy metals from contaminated soils is an emerging environmental cleanup and remedial biotechnology. In order to evaluate the risks of metal contamination in the area, it is essential to understand metal bioavailability, which depends on a metal s chemical form in the soil, rather than on the total amount accumulated (Allen, 1997 Zemberyova etal, 1998). [Pg.314]

A sufficient number of overtly healthy subjects over the age of 18, but under the age of 70, should be recruited into the study to ensure that at least 18 subjects per product evaluated complete the study. A reference product should be included in the study design to assure the internal validity of the study—i.e., that the reference product provides the same efficacy in this study as it has demonstrated in the past [9], Insofar as possible, to ensure an unbiased sampling, subject groups should be of mixed sex, age, and race. All subjects hands must be free of clinically evident dermatoses, injuries to the hands or forearms, open wounds, hangnails, and/or any other disorders that may pose a health threat to the subject. Standard institutional review board (IRB) procedures and protoeols should be in place and used throughout this evaluation. ... [Pg.296]

Considerable concern has been raised over the carcinogenic potential of 2,4-D. However, the World Health Organization (WHO) has evaluated the environmental health aspects of this chemical and concluded that 2,4-D posed an insignificant threat to the environment. They did indicate, however, that... [Pg.49]

Environmental contamination, either from diffuse or point sources, may compromise the ability of ecosystems to provide society with those goods and services that we require. Contamination is also linked to other widely recognised anthropogenic threats to sustainable functioning of our planet, such as the loss of biodiversity. As many soil properties and processes are conferred by soil biota, it is currently widely agreed that biological characteristics should be taken into account when evaluating the quality, or health, of soil [13, 16]. [Pg.12]

Continuous consumption of drugs even at sub-therapeutic concentrations represents a potential threat to public health, although one should bear in mind that it is still impossible to evaluate the effects of exposure on human health [58, 60, 118],... [Pg.231]

Risk assessment An evaluation of the potential impacts of a chemical or physical hazard on human health or the environment. A risk assessment is the first step in managing and minimizing risks. Risk assessments often include identifying human health or environmental threats, possible exposure routes (e.g. inhalation, digestion, or contact with skin), the likely duration of any exposure, and the individuals that are at risk (e.g. workers, the general public, or both). A risk assessment may also involve defining the probability of an adverse effect and establishing safety limits based on health standards. [Pg.464]

Depending on the needs of the individual pharmacy, several different types of insurance policies may be required to provide adequate risk protection for the business. The geographic location, type of practice, and services offered will influence the types of insurance needed. The risk management process is a continuous process, and periodic evaluations are necessary to address new or emerging risk threats to the pharmacy. Emerging threats discussed later in this chapter exemplify how recent changes in health care practices (privacy issues) and technology create new and different risk threats to the pharmacy. [Pg.493]

Section 5 of TSCA regulates the manufacture or import a new chemical substance for commercial purposes. Under this section, EPA requires notice before manufacture or importation of nonexempt substances. They then evaluate whether the chemical substance poses a threat to human health or the environment. This notice is called a PMN and must be submitted at least 90 days prior to the activity.34 Manufacturers must also submit information on significant new uses of existing chemicals to EPA for its review. After its review of the PMN or Significant New Use information, EPA may limit, restrict, or prohibit the manufacture, use, distribution, or disposal of the chemical substance. [Pg.676]

Risk evaluation in the assessment process focuses on weighing the health and environmental threats posed by an identified hazard. First, the possibility and probability that a person will actually experience an adverse effect as a result of the existence of the environmental hazard and exposure to it must be weighed and, secondly, the number of persons who might be exposed must be considered. [Pg.48]

Daniels, J.I. 1990. Lewisite. Pp. 6-1 to 6-22 in Evaluation of Military Field Water Quality, Vol. 4. Health Criteria and Recommendations for Standards, Part 2. Interim Standards for Selected Threat Agents and Risks from Exceeding these Standards. UCRL-21008 DTIC AD-A241523. Prepared by Lawrence Livermore Laboratory, University of California, Livermore, Calif., for the U.S. Army Medical Research and Development Comand, Fort Detrick, Frederick, Md. [Pg.108]


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