Fumaric acid Ferrous fumarate

Butenedioic acid ferrous salt. See Ferrous fumarate... 

CAS 141-01-5 EINECS/ELINCS 205-447-7 Synonyms 2-Butenedioic acid ferrous salt Iron (II) fumarate... 

The FCC is to food-additive chemicals what the USP—NF is to dmgs. In fact, many chemicals that are used in dmgs also are food additives (qv) and thus may have monographs in both the USP—NF and in the FCC. Examples of food-additive chemicals are ascorbic acid [50-81-7] (see Vitamins), butylated hydroxytoluene [128-37-0] (BHT) (see Antioxidants), calcium chloride [10043-52-4] (see Calcium compounds), ethyl vanillin [121-32-4] (see Vanillin), ferrous fumarate [7705-12-6] and ferrous sulfate [7720-78-7] (see Iron compounds), niacin [59-67-6] sodium chloride [7647-14-5] sodium hydroxide [1310-73-2] (see lkaliand cm ORiNE products), sodium phosphate dibasic [7558-79-4] (see Phosphoric acids and phosphates), spearmint oil [8008-79-5] (see Oils, essential), tartaric acid [133-37-9] (see Hydroxy dicarboxylic acids), tragacanth [9000-65-1] (see Gums), and vitamin A [11103-57-4]. 

Fumaric acid Sodium carbonate Ferrous sulfate... 

Procedure Weigh accurately about 0.3 g of ferrous fumarate and dissolve in 15 ml of dilute sulphuric acid by the help of gentle heating. Cool, add 50 ml of water and titrate immediately with 0.1 N ammonium ceric sulphate, employing ferroin sulphate solution as indicator. Each ml of 0.1 N ammonium ceric sulphate is equivalent to 0.01699 g of C4H2Fe04. 

Absorption of iron by the individual varies with age, iron status, the amount and chemical form of the iron ingested, and with conditions in the gastrointestinal tract, only about 5—15% of iron in the diet being normally absorbed. Ferrous iron, as the sulphate, gluconate, fumarate or lactate or as ferrous ammonium sulphate, is appreciably taken up into the bloodstream from the duodenum, especially in the presence of ascorbic acid, a reducing agent. Little difference was found in the extent of their absorption between ferrous sulphate and the various chelates, but ferric ammonium citrate or polysaccharide complexes were only very poorly absorbed22)... 

A 30-year-old woman had a hemoglobin concentration of 3.1 g/dl, a mean cell volume of 77 fl, a reticulocyte count of 2.13%, a platelet count of 426 x 10 /1, a serum iron concentration of 5 ng/ml, a transferrin saturation of 1%, and a ferritin concentration of 8 ng/ml. She was intolerant of oral iron and was given intramuscular iron dextran, 100 mg/day for 8 days, when she developed asymptomatic thrombocytopenia (platelet count 20 X 10 /1). Iron dextran was withdrawn and she took oral ferrous fumarate 200 mg/day plus ascorbic acid 120 mg/day. Within 2 days her platelet count improved. 

Iron deficiency anemia occurs mainly in infants, children, and fertile women. For this reason, a variety of foods, including infant formula and infant cereals, is fortified with iron. Ferrous sulfate is a form of iron that is most readily absorbed by the gut, but when added to dry cereals it can promote their spoilage and rancidity. For this reason, dry cereals are fortified with elemental iron particles, ferric pyrophosphate, or ferrous fumarate (Davidsson et ah, 1997). Ascorbic add may also be added to the cereal to enhance iron absorption. To view some of the numbers, infant cereals may contain 75 mg iron/kg cereal (1.3 mmol iron/kg), 1 mmol phytic acid/kg, and 2.6 mmol ascorbic acid/kg (Davidsson et cd., 1997). Although phytic acid impairs iron absorption, the added ascorbate serves to prevent this effect. An alternate method for preventing phytate from impairing iron absorption is to treat the food with the enzyme phytase. A parent interested in enhancing a child s iron absorption can easily feed a child some orange juice, but it would not be practical to pretreat the child s cereal with phytase. A typical availability of ferrous sulfate in infants is about 3-5% (with no ascorbate), and 6-10% (with ascorbate). Ascorbate is effective when present in a twofold molar excess over the iron. 

CAS 141-01-5. FeC4FL,04. Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly soluble in water. Combustible. 

Oral iron preparations Ferrous sulfate (tablets) Ferrous fumarate (tablets) Ferrous gluconate (tablets) Ferrous glycine sulfate (tablets or solution) Ferrous succinate (solution ) Sodium ironedetate (solution) Iron(ii) sulfate (40-105 mg Fe ) Iron(ii) fumarate (65-10 mg Fe ) Iron(ii) gluconate (35 mg Fe) Iron(n) glycine sulfate (25 100 mg Fe ) Iron(ii) succinate (37 mg Fe) Iron(n) chelate of ethylenediaminetetraacetic acid (FLDTA) (27.5 mg Fe)... 

Iron and copper phthalocyanines catalyze the isomerization of dimethyl maleate to dimethyl fumarate in the vapor phase at 300°C. No catalytic activity was observed in solution (338). Magnesium and zinc phthalocyanines catalyze the polymerization of methyl methacrylate when illuminated (Xm 600 m/i) (197). Manganous phthalocyanine (88) and ferrous phthalocyanine (59) catalyze the aerial oxidation of benzyl alcohol to benzaldehyde. The catalytic oxidation of ascorbic acid, using magnesium and copper derivatives, is light-sensitive (190, 310). a-Tetralin is catalytically oxidized, in the presence of the magnesium, zinc, or iron complexes, to a-tetralone, the reaction being chemiluminescent (60, 61,158,169, 371). The oxidation of luminol to 5-aminophthalazine-l,4-dione, catalyzed by iron phthalocyanine, is also chemiluminescent (61, 345, 361). 

Ingredients Calcium Carbonate, Microcrystalline Cellulose, Magnesium Oxide, Ferrous Fumarate, Ascorbic Acid, Maltodextrin, Gelatin, dl-Alpha-Tocopheryl Acetate, Dicalcium Phosphate Less than 2% of Beta-Carotene, Biotin, Cholecalciferol, Croscarmellose Sodium, Cupric Oxide, Cyanocobalamin, D-Calcium Pantothenate, FD C Red 40 Dye, FD C Red 40 Lake, FD C Yellow 6 Lake, Folic Acid, Hydroxypropyl Methylcellulose, Niacinamide, Polyethylene Glycol, Polysorbate 80, Potassium Iodide, Pyridoxine Flydrochloride, Riboflavin, Silicon Dioxide, Soybean Oil, Starch, Stearic Acid, Thiamine Mononitrate, Titanium Dioxide (color), Vitamin A Acetate, Zinc Oxide... 

Definition A salt of ferrous iron combined with fumaric acid, contg. 31.3% min. total iron, < 2% ferric iron... 

Ethylene distearamide , EthyleneA/A copolymer 2-Ethylhexanol Ferrous ammonium sulfate Fumaric acid Glyceryl acetate Glyceryl diacetate Hydrogenated castor oil Hydroxyethylcellulose Hydroxypropylcellulose Isopropyl acetate Isopropyl alcohol Itaconic acid Lanolin Lauryl alcohol Magnesium lauryl sulfate Magnesium myristate Magnesium palmitate Maleic acid Melamine-formaldehyde resin Methyl ethyl ketone ... 

Ferric pyrophosphate Ferric sodium pyrophosphate Ferrous fumarate Ferrous gluconate Ferrous gluconate dihydrate Ferrous lactate Ferrous sulfate anhydrous Ferrous sulfate heptahydrate Ferrous sulfate monohydrate Fumaric acid D-Gluconic acid Glucose L-Glutamic acid hydrochloride L-Glutamine Glycine Histidine hydrochloride monohydrate L-Histidine Inositol Iron Iron ammonium citrate... 

Ferric chloride . Ferric chloride hexahydrate Ferric sulfate Ferrous gluconate Ferrous gluconate dihydrate Fumaric acid Furfuryl mercaptan... 

Calcium carbide Calcium cyanamide Di-iron phosphide Magnesium iron oxide removal Citric acid iron processing Bismuth iron refining Calcium cyanamide iron removal Aluminum sulfate iron source Sodium ferric EDTA iron source, food Ferrous fumarate iron source, infant formulas Ferrous fumarate iron source, nutritional food Ferric pyrophosphate iron source, nutritional infant formulas Ferric pyrophosphate iron source, nutritional pharmaceuticals Ferric pyrophosphate iron source, pharmaceuticals Ferrous fumarate iron source, special dietary food Ferric choline citrate iron, tempering Potassium ferricyanide iron/manganese removal, water treatment Calcium hydroxide iron/steel casting Tellurium... 

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