Ferric chloride hexahydrate

A) -Naphthoquinone.—For the best results this preparation must be carried out rapidly. The vessels and reagents required should be made ready in advance. The oxidizing solution is prepared by dissolving 240 g. (0.89 mole) of ferric chloride hexahydrate in a mixture of go cc. of concentrated hydrochloric acid and 200 cc. of water with heating, cooling to room temperature by the addition of 200-300 g. of ice, and filtering the solution by suction. 

Chemical Designations - Synonyms Ferric Chloride (anhydrous). Ferric Chloride (hexahydrate). Iron (in) chloride. Iron perchloride. Iron trichloride Chemical Formula FeClj or FeCl3 6H20. Observable Characteristics - Physical State (as shipped) Solid Color Anhydrous greenish black, Hidrate brown Odor None. 

Ferric chloride hexahydrate Iron chloride, hexahydrate (8,9) (10025-77-1) Potassium fluoride (8,9) (7789-23-3)... 

A solution of 0.54 g. (2 mmoles) of ferric chloride hexahydrate and 0.33 g. (3 mmoles) of diethylammonium chloride (Note 1) in 5 g. of methanol is added to a solution of 11.2 g. (0.1 mole) of 1-octene (Note 2) and 0.42 g. (2 mmoles) of benzoin (Note 3) in 36 g. (0.3 mole) of chloroform (Note 4). The resulting homogeneous mixture is introduced into a Carius tube of about 100-ml. capacity. Air is displaced by dropping a few pieces of dry ice into the tube (Note 5). The tube is sealed (Note 6), heated to 130°, kept at that temperature for 15 hours, cooled to room temperature (Note 7), and opened. The contents of the tube are transferred to a separatory fuimel, and the tube is rinsed with about 10 ml. of chloroform. The reaction mixture is washed with 40 ml. of water. The aqueous solution is extracted with 10 ml. of chloroform, and the extract is added to the original chloroform layer. Solvent is distilled at atmospheric pressure (bath temperature up to 130°). The distillation flask is allowed to cool, and distillation is continued at 25 mm. (bath temperature up to 120°) (Note 8). The flask is cooled again, and distillation is continued to dryness at 0.1 mm. (bath temperature up tc 150°), giving crude l,l,3-trichloro- -nonane (19.4 g.) as a yellow oil, b.p. 60-85° (0.1 mm.), 1.4650. The purity of this... 

A similar method can be used for the addition of carbon tetrachloride to nonpolymerizable olefins (e.g., 1-octene, 2-octene, 1-butene, 2-butene) pure adducts are obtained in yields of over 90% if the components are allowed to react at 100° for 6 hours. Adducts of carbon tetrachloride with vinylic monomers (styrene, butadiene, acrylonitrile, methyl acrylate, etc.) can be prepared in good yields by substituting cupric chloride dihydrate in acetonitrile for ferric chloride hexahydrate and benzoin. 

Sen SE, Roach SL, Boggs JK, Ewing GJ, Magrath J (1997) Ferric chloride hexahydrate a mild hydrolytic agent for the deprotection of acetals. J Org Chem 62 6684—6686... 

Whole-body isotope retention experiments were performed (via the method described above in the Smith experiment and with confirmed corrections for isotope decay rates), using extrinsically labeled ferric chloride hexahydrate and Ca from CCM (i.e., [ FeJFeCla and [" Ca] CaCl2) to determine the bioavailability of these minerals at an Fe Ca ratio of 1 167 mol/mol. CCM solubility was also assessed via a filtration method. 

One reagent is a 0.5% aqueous solution of 3-methylbenzothiazolin-2-one hydrazone hydrochloride, and the other is a 0.25% aqueous solution of ferric chloride hexahydrate. To run the procedure, one introduces 1 mL of the sample solution in chloroform into a tube, and carefully evaporates to dryness on a steam-bath. No trace amount of the solvent should remain in the tube since it inhibits the reaction. 1 mL of water is added to the tube, then 0.5 mL of the 3-methylbenzothiazolin-2-one hydrazone reagent and 0.5 mL of O.IN sodium hydroxide. This mixture is heated at 100°C for 10 minutes, and cooled for 5 minutes in a 15°C water bath. After that, one adds 0.5 mL of IN hydrochloric acid and 2 mL of the ferric chloride reagent. The resulting solution is allowed to stand for 1 hour at room temperature, and the absorbance read at 630 nm. In a 1 cm cell an absorbance of 0.3 was obtained for 21 pg of cortisone, 18 pg of hydrocortisone, 17 pg of prednisone, or 19 pg of prednisolone. 

Fermentation Alcohol Fermentation Amyl Alcohol Fermentation Butyl Alcohol Ferric Ammonium Citrate Ferric Ammonium Citrate, Brown Ferric Ammonium Citrate, Green Ferric Ammonium Oxalate Ferric Chloride Ferric Chloride, Anhydrous Ferric Chloride, Hexahydrate Ferric Glycerophosphate Ferric Nitrate Ferric Nitrate Nonahydrate Ferric Sulfate... 

Bromo-ll//-pyrido[2,l-b]quinazolin-ll-one and its 8-methyl and 8-isopropyl derivatives (127, R = Br, R1 = H, Me, iPr) were treated with carbon monoxide and nickel carbonyl in wet dimethylformamide in the presence of calcium hydroxyde to yield 2-carboxylic acid derivatives (127, R = COOH, R1 = H, Me, iPr). 2-Bromo-8-isopropyl-ll//-pyrido[2,l-b]-quinazolin-ll-one (127, R = Br, R1 = iPr) was reacted with copper(I) cyanide in iV-methyl-2-pyrrolidone at 180°C for 10 h, then with ferric chloride hexahydrate in diluted hydrochloric acid at 90°C for 30 min to give the 2-cyano derivative (127, R = CN, R1 = iPr) (85CP1189509). 

N-Methyl-2-pyrrolidone Ferric chloride hexahydrate Glycol monomethyl ether Lithium aluminum hydride Ruthenium on charcoal Magnesium ethoxide 4-Toluenesulfonic acid Sodium bicarbonate 1,2,3,4-Tetrafluoro benzene Palladium on charcoal Cyclopropylamine N-benzylimide... 

A mixture of the oily product (22 g), cuprous cyanide (10 g) and N-methyl-2-pyrrolidone (37 ml) in sealed tube was heated for 4.5 h at 140° to 150°C. After cooling, a solution of ferric chloride hexahydrate (44 g) and concentrated hydrochloric acid (11 ml) in water (60 ml) was added to the reaction mixture and then stirred at 50° to 60°C for 20 min. The reaction mixture was extracted with ether and the organic layer was washed with dilute aqueous hydrochloric acid, with water and with saturated saline solution successively, and dried over anhydrous sodium sulfate and then concentrated. The residue was purified by distillation under reduced pressure to give 3-methoxy-2,4,5-trifluorobenzonitrile (14.25 g) as colorless oil, boiling point 94°C/8 mm Hg. 

Determination of the Hydroperoxide. Glacial acetic acid (30 ml.) containing 0.0005% ferric chloride hexahydrate and 5 ml. saturated potassium iodide solution was added to an aliquot of the hydroperoxide solution which had been flushed with nitrogen. The mixture was stored in the dark for 10 minutes, diluted with water (50 ml.), and the liberated iodine was titrated with sodium thiosulfate solution using starch as indicator. 

Urushibara Fe,128 To a well-mixed zinc dust (25 g) and water (8 g) placed in a 50-ml beaker is added 9.68 g (2 g of Fe) of ferric chloride hexahydrate (FeCl3 6H2O). The mixture is then well stirred with a glass rod. Soon a vigorous exothermic reaction starts, but subsides within about 10 s. To complete the reaction, the mixture is stirred until the color of the ferric ion disappears. The reaction mixture is washed with 400... 

The Step 1 product (105 mg) dissolved in 6 ml dry DMF was treated with 75% NaH (0.94 mmol), then stirred 5 minutes, and treated with 2-chloroethylpyrrolidine hydrochloride (0.60 mmol). The mixture stirred 2 hours at 50°C and was then partitioned between CHCl3/2-propyl alcohol/water, 10 1 1, and the organic phase isolated. The solution was washed twice with water, once with brine, dried with K2C03, then concentrated, and 130 mg of a light yellow solid isolated. The residue was dissolved in 8 ml methyl alcohol, then treated with ferric chloride hexahydrate (0.11 mmol), charcoal (5 mmol), and 1,1-dimethyl hydrazine (25 mmol), then refluxed 3 hours. 

Standard Iron Solutions. Dissolve 0.484 g of ferric chloride hexahydrate in sufficient M hydrochloric acid to produce 100 ml. This solution contains 1 mg of Fe in 1 ml. Serially dilute die solution widi sodium chloride-potassium chloride solution to produce solutions containing 0.5, 1.0, 1.5, 2.0, and... 

Ferric Chloride on Attapulgus Clay. Ferric chloride hexahydrate (40 g), a 10% solution in methanol, was contacted with Attapulgus clay (252 g) for 8 hr. The ferric chloride-Attapulgus clay was filtered, washed several times with cyclohexane, extracted with cyclohexane for 24 hr in a Soxhlet extractor to remove nonadsorbed metallic salt, and dried at room temperature. The material contained 0.7-2.0 wt % of iron. 

Christoffers, J. Catalysis of the Michael reaction and the vinylogous Michael reaction by ferric chloride hexahydrate. Synlett 200, 723-732. 

A fladk was charged with 0.625 m< of aniline hydrochloride, 1 mole of ferric chloride hexahydrate, 10 g. of anhydrems zinc chloride, and 450 ml. of 95% ethanol. The nixture was stiired at 60-65°, and 0.5 mole of methyl vinyl ketone, 1,3,3-trimefhoxybutane, or 4-methoxy-24butanone was added dropwise in li-2 hrs. After refluxing for 2 hrs., the alcohol was largely removed and the mixture made alkaline and steam distilled. 

Phenolic oxidative coupling. Oxidation of the phenolic amine (1) with 4.1 molar equivalents of ferric chloride hexahydrate gives 5-hydroxy-6-methoxyindole (2) in 10.6% yield. The amino nitrogen can also be substituted by an alkyl group.1... 

Bovine serum albumin (BSA, Fraction V powder), sodiiun dodecyl sulfate (SDS lauryl sulfate, sodium salt), triethanolamine (TEA), ferric chloride hexahydrate, potassium metabisulfite and (+)-catechin were pivchased from Sigma, St. Louis MO, as were all of the reagents used for preparing buffers. 

IRON TRICHLORIDE (7705-08-0) FeCl3 6H20 Noncombustible solid. Very hygroscopic contact with moisture in air forms ferric chloride hexahydrate. Aqueous solution is highly acidic, precipitating hydroxide and phosphate salts, and, forming corrosive fumes. Violent reaction with strong... 

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