Sodium phosphate dibasic

Disodium hydrogen phosphate Disodium hydrogen phosphate dodecahydrate Dibasic sodium phosphate Dinatrii phosphas anhydricus Dinatrii phosphas dihydricus Dinatrii phosphas dodecahydricus Dibasic sodium phosphate Note that the BP 2004 and PhEur 2005 contain three separate monographs for the anhydrous, the dihydrate, and the dodecahydrate the JP 2001 contains one monograph for the dodecahydrate and the USP 28 contains one monograph for the anhydrous, the monohydrate, the dihydrate, the heptahy-drate, and the dodecahydrate. See also Section 8. 

Disodium hydrogen phosphate disodium phosphate E339 phosphoric acid, disodium salt secondary sodium phosphate sodium orthophosphate. 

Anhydrous dibasic sodium phosphate [7558-79-4] Dibasic sodium phosphate dihydrate [10028-24-7] Dibasic sodium phosphate dodecahydrate [10039-32-4] Dibasic sodium phosphate heptahydrate [7782-85-6] Dibasic sodium phosphate hydrate [10140-65-5] Dibasic sodium phosphate monohydrate [118830-14-1] 

Dibasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, dibasic sodium phosphate is used as a mild laxative and in the treatment of hypophosphatemia.  

Dibasic sodium phosphate is also used in food products for example as an emulsifier in processed cheese. 

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The FCC is to food-additive chemicals what the USP—NF is to dmgs. In fact, many chemicals that are used in dmgs also are food additives (qv) and thus may have monographs in both the USP—NF and in the FCC. Examples of food-additive chemicals are ascorbic acid [50-81-7] (see Vitamins), butylated hydroxytoluene [128-37-0] (BHT) (see Antioxidants), calcium chloride [10043-52-4] (see Calcium compounds), ethyl vanillin [121-32-4] (see Vanillin), ferrous fumarate [7705-12-6] and ferrous sulfate [7720-78-7] (see Iron compounds), niacin [59-67-6] sodium chloride [7647-14-5] sodium hydroxide [1310-73-2] (see lkaliand cm ORiNE products), sodium phosphate dibasic [7558-79-4] (see Phosphoric acids and phosphates), spearmint oil [8008-79-5] (see Oils, essential), tartaric acid [133-37-9] (see Hydroxy dicarboxylic acids), tragacanth [9000-65-1] (see Gums), and vitamin A [11103-57-4]. 

Chemical Designations - Synonyms Sodium phosphate is generic term and includes the following (1) monosodium phosphate (MSP sodium phospWe, monobasic), (2) disodium phosphate (DSP sodium phosphate dibasic), (3) trisodium phosphate (TSP sodium phosphate, tribasic), (4) sodium acid pyrophosphate (ASPP SAPP disodium pyrophosphate (TSPP), (6) sodium metaphosphate (insoluble sodium metaphosphate), (7) sodium trimetaphosphate, and (9) sodium tripolyphosphate (STPP TPP) Chemical Formula (1) NaHjPO (2) Na HPO (3) NajPO (4) Na H P O, (5) Na P O, (6) (NaPOj) (7) (NaP03)3 (8) (NaP03) NaO (9) Na,P30,o. 

Avastin Avastin is used for the treatment of colorectal cancer. It is supplied in 100 and 400 mg dosages. The 100 mg formulation consists of 240 mg a,a-trehalose dihydrate, 23.2 mg sodium phosphate (monobasic, monohydrate), 4.8mg sodium phosphate (dibasic, anhydrous), 1.6mg polysorbate 20 and water-for-injection. 

PEG-Intron PEG-Intron is used for the treatment of hepatitis C. The product consists of a covalent conjugate of the recombinant interferon- -2b with monomethoxy polyethylene glycol (PEG) supplied in vials with 74/rg, 118.4/rg, 177.6/rg, or 222/rg of the active ingredient and 1.11 mg sodium phosphate (dibasic,anhydrous),l.ll mg sodium phosphate (monobasic, dihydrate), 59.2 mg sucrose, and 0.074mg polysorbate 80. The powder is reconstituted with sterile water-for-injection. 

Formulation Aranesp is formulated as a sterile, colorless, preservative-free protein solution for intravenous (IV) or subcutaneous (SC) administration. There are two formulations the polysorbate solution includes excipients such as polysorbate 80, sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous, and sodium chloride in water-for-injection while the albumin solution contains albumin, sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous, and sodium chloride in water-for-injection. The pH for both formulations is 6.2 + 0.2. 

Phosphate-buffered saline (PBS), pH 7.4 1.7 mM potassium phosphate monobasic, 5 mM sodium phosphate dibasic, and 150 mM sodium chloride. 

Extraction with buffer pH 4 (citric acid in sodium phosphate dibasic hepthydrate), SPE C8, ethyl acetate methanol (75 25, v/v) elution MM-CPE based on mixed micellar extractants of Triton X-114 and CTAB Selective SPE (SupelMlP, 3% NH40H in MeOH water, 1 1, v/v)... 

A new formulation of a saline laxative, Visicol, that is useful to prepare patients for procedures, was approved for use in 2001. Each 2-g tablet contains 1.102 g sodium phosphate monobasic monohydrate and 0.398 g sodium phosphate dibasic anhydrous, for a total of 1.5 g sodium phosphate. Visicol tablets, taken in two doses of 30 g approximately 12 hours apart, induce diarrhea that rapidly and effectively cleanses the entire colon. Each administration has a purgative effect for approximately 1 to 3 hours. 

With gentle stirring, add sodium phosphate, dibasic, into the solution. Stir for 10 minutes or until completely dissolved. During this mixing period, remove samples from the bottom valve of the manufacturing tank and inspect for clarity. Return samples to the manufacturing tank. 

CHO-expressed glycoprotein] Pharmaceuti- (single-dose vial) cals mL (pH = 5.5) 43.9mg sodium chloride 63.5mg sodium phosphate monobasic monohydrate 10.7 mg sodium phosphate dibasic heptahydrate 0.05 mg polysorbate 80 0.9% NaCl containing 1% HSA prior to administration)... 

Formulation buffer vial containing 750 mg if human albumin 76 mg of sodium chloride 21 mg of sodium phosphate dibasic heptahydrate 4 mg pentetic acid 2 mg potassium phosphate monobasic 2 mg of potassium chloride lOmL of water (pH 7.1)... 

Pre filled syringe polysorbate-80 containing (HSA- free) formulation glycine polysorbate 80 sodium chloride sodium phosphate monobasic dihydrate sodium phosphate dibasic dihydrate water for injection... 

Per 1 mL 2.5 mg albumin (human) 1.2 mg sodium phosphate monobasic monohydrate 1.8 mg sodium phosphate dibasic anhydrate 0.7 mg sodium citrate 5.8 mg sodium chloride 6.8 pg citric acid in WFI, USP... 

To be reconstituted with 1 mL sterile WFI containing 1.0 mg Poloxamer 188 (0.15mg/mL) Per 5mg vial 33.0mg mannitol 3.0mg sodium phosphate monobasic monohydrate 8.8 mg sodium phosphate dibasic heptahydrate Per vial 10.6 mg mannitol IV 15.9mg/mL L-alanine 12.6-14.3 mg of dibasic sodium phosphate... 

Per 1 mL polysorbate solution 0.05mg/mL polysorbate 80 2.12mg/mL sodium phosphate monobasic monohydrate 0.66mg/mL sodium phosphate dibasic anhydrous 8.18mg/mL sodium chloride (pH 6.2 0.2)... 

Per 1 mL 1.36 mg glycine 36.0 mg mannitol 1.04mg sodium phosphate dibasic anhydrous 0.36 mg sodium phosphate monobasic monohydrate... 

Sodium phosphate monobasic [S 9638], sodium phosphate dibasic [S 0876], sodium chloride [S 7653], acetylcholinesterase from Elect-rophorus electricus (Type V-S) [C 2888], potassium chloride [P 3911], 1,2-diaminobenzenedihydrochloride [P 1526], paraoxon (o,o-diethyl o-4-nitrophenyl phosphate) [D 9286], ferrocene carboxylic acid [106887], aniline [A 9880] and acetylthiocholine chloride [A 5751] were purchased from the Sigma Chemical Company (Dorset, UK). Screen-printed transducers were purchased from Gwent Electronic Materials Ltd. (Gwent, Wales, UK). These electrode assemblies comprised a working electrode based on carbon ink doped with cobalt phthalocya-nine, an on board reference electrode (Ag/AgCl) and counter electrode (platinum) (see Fig. 24.1). 

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