Thiamine mononitrate

Thiamine Mononitrate, MSDS 3835, Hoffmann-La Roche Inc., Nutley, N.J. 

Vitamin Bj or thiamine (Figure 19.21) is 3-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazolium. It is isolated, synthesized, and used in food supplements and in food fortifications as a solid thiazolium salt in the form of thiamine hydrochloride or thiamine mononitrate [403]. 

For stability reasons it would be better to substitute thiamine hydrochloride by thiamine mononitrate in formulation No. 2. 

In this form and as other salts, such as thiamine mononitrate, the vitamin is available as a dietary supplement. 

Ncphrocaps Ascorbic acid, folate, niacinamide, thiamine mononitrate, riboflavin. pyridoxinc HC1. cyanocobalamin, calcium junlnthetialr. jnd biotin ... 

Thiamine Mononitrate occurs as white to yellow-white crys-... 

The free base is unstable, and two derivatives of thiamin are commonly used in food enrichment and pharmaceutical preparations thiamin chloride hydrochloride (generally known simply as thiaminhydrochloride) and thiamin mononitrate. The mononitrate is less hygroscopic than the chloride hydrochloride and is the preferred form for food enrichment. There is considerable difficulty in interpreting much of the literature on thiamin requirements, because many authors quote mg of thiamin, without specifying whether it was as the free base, the chloride hydrochloride, or the equivalent amount of free base. Because the Mr of free thiamin is 266.4, and that of the chloride hydrochloride is 337.3, this confusion can result in errors of the order of 26%. 

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