Electrospray ionization—tandem mass determination

Li, H. et ah. Determination of carotenoids and all-fra 5-retinol in fish eggs by liquid chromatography-electrospray ionization-tandem mass spectrometry, J. Chromatogr. B, 816, 49, 2005. 

A different strategy has been applied in our work, that emphasizes the importance of DNA stability on hole transfer within double-stranded DNA. This work is based on determination of the overall yield of oxidized nucleosides that arise from the conversion of initially generated purine and pyrimidine radical cations within DNA exposed to two-photon UVC laser pulses. On the one hand, this work benefits from the excellent current knowledge of chemical reactions involving the radical cations of DNA bases, and on the other hand, from major analytical improvements that include recent availability of the powerful technique of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (CLHP-ESI-MS/MS) [16-18]. 

Pruvost A. et al., 2000. Fully automated determination of eserine N-oxide in human plasma using online solid-phase extraction with liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Mass Spectrom 35 625. 

Raices R.S.L. et al., 2003. Determination of stavudine in human serum by online solid-phase extraction coupled to high-performance liquid chromatography with electrospray ionization tandem mass spectrometry Application to a bioequivalence study. Rapid Commun Mass Spectrom 17 1611. 

T. Reemtsma, Analysis of sulfophtalimide and some of its derivatives by liquid chromatogra-phy-electrospray ionization tandem mass spectrometry. J. Chromatogr., 919 (2001) 289-297. C. Rafols and D. Barcelo, Determination of mono- and disulfonated azo dyes by liquid-chro-matography-atmospheric pressure ionization mass spectrometry. J. Chromatogr.A, 111 (1997) 177-192. 

Tian Q, Rosselot RA, Schwartz SJ (2005) Quantitative determination of intact glucosinolates in broccoli, broccoli sprouts, brussels sprouts, and cauliflower by high-performance hquid chromatography-electrospray ionization-tandem mass spectrometry. Anal Biochem 343 93-99... 

Zaffiro AD, Zimmerman M, Pepich BV, Slingsby RW, Jack RE, Pohl CA, Munch DJ (2009) EPA Method 557. Determination of haloacetic acids, bromate, and dalapon in drinking water by ion chromatography electrospray ionization tandem mass spectrometry (IC-ESI-MS/MS). U.S. EPA, Cincinnati, OH, Available at http //water.epa.gov/scitech/drinkingwaterAabcert/ uploadZmet557.pdf... 

Xu WH, Zhang G, Zou S-C et al (2007) Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography— electrospray ionization tandem mass spectrometry. Environ Pollut 145 672-679... 

AmnaT et al. Determination and quantification of camptothecin in an endophytic fungus by liquid chromatography-positive mode electrospray ionization tandem mass spectrometry, Curr Sci 91 208—212, 2006. 

Miao X. and C.D. Metcalfe (2003). Determination of pharmaceuticals in aqueous samples using positive and negative voltage switching microhore liquid chromatography/electrospray ionization tandem mass spectrometry. Journal of Mass Spectrometry 38 27-34. 

A selective, sensitive, and rapid hydrophilic interaction liquid chromatography with electrospray ionization tandem mass spectrometry was developed for the determination of donepezil in human plasma [32], Donepezil was twice extracted from human plasma using methyl-ferf-butyl ether at basic pH. The analytes were separated on an Atlantis HILIC Silica column with the mobile phase of acetonitrile ammonium formate (50 mM, pH 4.0) (85 15, v/v) and detected by tandem mass spectrometry in the selective reaction monitoring mode. The calibration curve was linear (r = 0.9994) over the concentration range of 0.10-50.0 ng/ ml and the lower limit of quantification was 0.1 ng/ml using 200 /d plasma sample. The CV and relative error for intra- and inter-assay at four quality control levels were 2.7% to 10.5% and —10.0% to 0.0%, respectively. There was no matrix effect for donepezil and cisapride. The present method was successfully applied to the pharmacokinetic study of donepezil after oral dose of donepezil hydrochloride (10 mg tablet) to male healthy volunteers. 

Yamashita K, Okuyama M, Watanabe Y, Honma S, Kobayashi S, NumazawaM (2007) Highly sensitive determination of estrone and estradiol in human serum by liquid chromatography-electrospray ionization tandem mass spectrometry. Steroids 72 819-827... 

Bai F et al (2011) Determination of vandetanib in human plasma and cerebrospinal fluid by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci 879 2561-2566... 

EPA EPA Chemical QC Guidelines EPA method 539 Determination of hormones in drinking water by solid phase extraction (SPE) and liquid chromatography electrospray ionization tandem mass spectrometry (LC-MS/MS) [77]... 

Huang DK, Liu C, Huang MK, Chien CS (2009) Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/ electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 23(7) 957-962. doi 10.1002/rcm.3955... 

W.A. Tao et al., Rapid enantiomeric determination of a-hydroxy acids by electrospray ionization tandem mass spectrometry. Chem. Commun. 20, 2023-2024 (2000)... 

Tak, V. et al. Application of Doehlert design in optimizing the determination of degraded products of nerve agents by ion-pair liquid chromatography electrospray ionization tandem mass spectrometry. J. Chromatog. A. 2007, 1161, 198-206. 

Lan, K. et al. Quantitative determination of rosuvastatin in human plasma hy ion-pair liquid-hquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry. J. Pharm. Biomed. 2007, 44, 540-546. 

H. Rosing, M. J. X. HUlebrand, J. M. Jimeno, A. Gomez, and P. Floriano, Quantitative determination of Eteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry,/. Mass Spectrom. 33 (1998), 1134-1140. 

MORTENSEN s K, TRIER X T, FOVERSKOV A and PETERSEN J H (2005), Specific determination of 20 primary aromatic amines in aqneons food srmnlants by Uqnid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatoeraphy A, 1091, Issnes 1-2, 40-50. 

Sandhoff R, Briigger B, Jeckel D, Lehmann WD, Wieland FT. Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. J. Lipid Res. 1999 40 126-132. 

Riediker, S. Stadler, R.H. Simultaneous determination of five P-lactam antibiotics in bovine milk using liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Anal. Chem. 2001, 73, 1614-1621. 

Cui, D. and Harvison, P.J., Determination of the site of glucuronidation in an N-(3,5-dichlorophenyl)succinimide metabolite by electrospray ionization tandem mass spectrometry following derivatization to picolinyl esters, Rapid Commun. Mass Spectrom., 14(21), 1985, 2000. 

Lemire SW, Ashley DL and Calafat AM (2003). Quantitative determination of the hydrolysis products of nitrogen mustards in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. J Anal Toxicol, 27,1-6. 

X Cahours, H Dessans, P Morin, M Dreux, L Agrofoglio. Determination at ppb level of an anti-human immunodeficiency virus nucleotide drug by capillary electrophoresis-electrospray ionization tandem mass spectrometry. J Chromatogr A 895 101-109, 2000. 

Kamel, A., Prakash, C., and Obach, S. (2002) Determination of the enzyme involved in the reductive metabolism of ziprasidone to dihydroziprasidone and the formation of S-methyl dihydroziprasidone using human in vitro systems and electrospray ionization tandem mass spectrometry. Proceedings of the 50th ASMS Conference, Orlando, USA. 

Both quantitative approaches have drawbacks. For instance, the current mass spectrometric method does not distinguish between the various isomers of IsoK/LG adducts and thus provides no information on the pathway leading to adducts. Because complete proteolyis is required, it is also not possible to specifically determine the identity of the adducted protein. The method is also very time-consuming and limited to labs with electrospray ionization tandem mass spectrometers and associated expertise. In contrast to mass spectrometry methods, antibody based methods are relatively easy and inexpensive however. 

Kim, M.-J. and Y.-H. Kim Determination of phenols in mainstream cigarette smoke by isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometer 61st Tobacco Science Research Conference, Program Booklet and Abstracts, Vol. 61, Paper No. 20, 2007, pp. 26-27. 

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