Atmospheric pressure ionization-mass spectrometry

Anacardio, R., Cantalini, M.G., De Angelis, F., and Gentile, M., Quantification of S-carboxymethyl-(R)-cysteine in human plasma by high-performance ion-exchange liquid chromatography/atmospheric pressure ionization mass spectrometry, /. Mass Spectrom., 32, 388, 1997. 

Ahrer, W. and Buchberger, W., Analysis of low-molecular-mass inorganic and organic anions by ion chromatography-atmospheric pressure ionization mass spectrometry, /. Chromatogr A, 854, 275, 1999. 

Johansson, I. M., Pavelka, R., and Henion, J. D., Determination of small drug molecules by capillary electrophoresis-atmospheric pressure ionization mass spectrometry /. Chromatogr., 559, 515, 1991. 

Ketkar SN, Penn SM, Fite WL. 1991. Influence of coexisting analytes in atmospheric pressure ionization mass spectrometry. Anal Chem 63(9) 924-925. 

D. I. Carroll, I. Dzidic, R. N. Stillwell, K. D. Haegele and E. C. Homing, Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph mass spectrometer computer analytical system, Anal. Chem., 47, 2369 2373 (1975). 

A.P. Bruins, T.R. Covey and J.D. Henion, Ion spray interface for combined liquid chromato graphy/atmospheric pressure ionization mass spectrometry, Anal. Chem., 59,2642 2646 (1987). 

FIGURE 3.1 Comparison of atmospheric pressure ionization mass spectrometry and other widely used analytical methods for analysis of small organic molecules. 

A.P. Bruins, Atmospheric pressure ionization-mass spectrometry I. Instrumentation and ionization techniques, Trends Anal. Chem., 13 (1994) 37-43. 

Kostiainen, R., Kotiano, T., Kuuranne, T. and Auriola, S. (2003) Liquid chromatography-atmospheric pressure ionization/mass spectrometry (LC-API/ MS) in drug metabolism studies. Journal of Mass Spectrometry, 38, 357-372. 

The application of liquid chromatography-atmospheric pressure ionization-mass spectrometry in water analysis has been previously reviewed. The application of this technique for the analysis of synthetic dyes was also discussed [118]. 

T. Reemtsma, Analysis of sulfophtalimide and some of its derivatives by liquid chromatogra-phy-electrospray ionization tandem mass spectrometry. J. Chromatogr., 919 (2001) 289-297. C. Rafols and D. Barcelo, Determination of mono- and disulfonated azo dyes by liquid-chro-matography-atmospheric pressure ionization mass spectrometry. J. Chromatogr.A, 111 (1997) 177-192. 

Desai, M.J. and Armstrong, D.W., Analysis of derivatized and underivatized thean-ine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry. Rapid Commun. Mass Spectrom., 18, 251,2004. 

Hirabayashi, A., Sakairi, M., Takada, Y., and Koizumi, H. (1997). Recent progress in atmospheric-pressure ionization mass-spectrometry. Trends Anal. Chem. 16, 45—52. 

G.A. Eiceman, J.H. Kremer, A.P. Snyder and J.K. TofFeri, Quantitative assessment of a corona discharge ion source in atmospheric pressure ionization-mass spectrometry for ambient air monitoring. International Journal of Environmental Analayrical Chemistry 33 (1988) 161—183. 

X. Xu, A.M. van der Craats and P.C.A.M. de Bmyn, Highly sensitive screening method for nitroaromatic, nitramines and nitrate ester explosives by high performance liquid chromatography — atmospheric pressure ionization — mass spectrometry (HPLC-APl-MS) in forensic applications , J. Forensic Sci., 49 No. 6 (2004) 1171-1180. 

Note The acronyms used here are OSPED (optical spectroscopy in a pulsed electrical discharge), FAMS (flowing afterglow mass spectrometry), SIFT (selected ion flow tube), TRAPI (time-resolved atmospheric pressure ionization mass spectrometry), PHPMS (pulsed high-pressure ionization mass spectrometry), ICRMS (ion cyclotron resonance mass spectrometry), and ADO (averaged dipole orientation collision rate theory). 

Carboxylic acids The smallest carboxylic acid, formic acid, can be measured using infrared spectroscopy (Table 11.2), since it has characteristic absorption bands. As discussed earlier and seen in Fig. 11.33b, mass spectrometry with chemical ionization using SiF5 also revealed HCOOH in an indoor environment (Huey et al., 1998). However, since the sensitivity in these initial studies was about two orders of magnitude less than that for HN03, the detection limit may be about the same as that for FTIR and TDLS. Formic and acetic acids have been monitored continuously from aircraft (Chapman et al., 1995) and their surface flux determined by eddy correlation (Shaw et al., 1998) using atmospheric pressure ionization mass spectrometry. Detection limits are about 30 ppt. 

Yerelzian, C., Jordan, A., Brevard, H., Lindinger, W. (2000) Identffication of volatile compunds iKing combined gas chromotography electron impact atmospheric pressure ionization mass spectrometry. In Taylor, A.J., Roberts, D.D. (eds) Flavour Release, ACS Symposium Series 763. American Chemical Society, Washington, pp 58-72. 

Figure 22-17 (a) Pneumatically assisted electrospray interface for mass spectrometry. (fc>) Gas-phase ion formation. [Adapted from E. C. Huang, T. Wachs, J. J. Conboy, and J D. Henlon, "Atmospheric Pressure Ionization Mass Spectrometry. Anal. Chem. 1990, 62. 713A. and P Kebarte and L Tang, Rom Ions in Solution to Ions in the Gas Phase, Anal. Chem. 1993,65.972A ] (c) Electrospray from a silica capillary. [Courtesy R. D. Smith. Pacific Northwest Laboratory, Richland, WAJ... 

Brum, J. Dell Orco, P. Lapka, S. etal., Monitoring organic reactions with on-line atmospheric pressure ionization mass spectrometry The hydrolysis of isatin Rapid Commun. Mass Spectrom. 2001, 15, 1548-1553. 

A. High-performance liquid chromatography-mass spectrometry Weidolf and Covey [121] described the application of the ionspray interface for liquid chromatography and atmospheric-pressure ionization mass spectrometry to samples obtained in a study on the metabolism of... 

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