Endophytic fungus

The fermentation broth of an unidentified endophytic fungus isolated from plants growing in Hawaii has afforded microcarpalide I (59), an alkyl-substituted nonenolide that is weakly cytotoxic as a result of its ability to disrupt microfilaments. Extracts from the strain 112/13 collected from the bark oiFicus microcarpa L. (Moraceae) demonstrated a strong abrogation of microfilament activity. In A-10 rat smooth muscle cells, a 5 Xg/mL dose was able to induce a 50%—75% loss of actin filaments. Microcarpalide 1... 

Puri SC, Verma V, AmnaT, Qazi GN, Spiteller M, An endophytic fungus from Nothapodytes foetida that produces camptothecin, J Nat Prod 68 1717—1719,... 

Wagenaar M, Corwin J, Strobel G, Clardy J, Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella, J Nat Prod... 

Chomcheon P, Sriubolmas N, Wiyakrutta S, Ngamrojanavanich N, Chaichit N, Mahidol C, Ruchirawat S, Kittakoop P, Cyclopentenones, scaffolds for organic syntheses produced by the endophytic fungus Mitosporic dothideomycete sp. 

Stierle A, Strobel G, Stierle D, Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew, Science 260 214-216, 1993. 

Puri SG, Nazir A, Ghawla R, Arora R, Riyaz-ul-Hasan S, Amna T, Ahmed B, Verma V, Singh S, Sagar R, Sharma A, Kumar R, Sharma RK, Ghulam NQ, The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllo-toxin and related aryl tetralin Yign2isi, J Biotechnol 122 494-510, 2006. 

AmnaT, Puri SG, Verma V, Sharma JP, KhajuriaRK, MusarratJ, Spiteller M, Qazi GN, Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin, Can J Microbiol 52 189-196, 2006. 

Bashyal BP, Wijeratne EMK, Faeth SH, Gunatilaka AAL, Globosumones A—G, cytotoxic orseUinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum, J Nat Prod 6 724—72%, 2005. 

Klemke G, Kehraus S, Wright AD, Konig GM, New secondary metabolites from the marine endophytic fungus Apiospora montagnei, J Nat Prod 67 1058-1063, 2004. 

Brady SF, Singh MP, Janso JE, Clardy J, Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus, Organic Lett 2 4047-4049, 2000. 

Filip P Weber RW, Sterner O, Anke T, Hormonemate, a new cytotoxic and apoptosis-inducing compound from the endophytic fungus Hormonema dema-tioides. I. Identification of the producing strain, and isolation and biological properties of hormonemate, Z Naturforsch 58 547—552, 2003. 

Ratnayake AS, Yoshida WY, Mooberry SL, and Hemscheidt T. The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus, Organic Lett 3 3479-3481,2001. 

Zhang L et al. Isolation and determination of the anti-cancer substance chaetoglobosin A from endophytic fungus oiMaytenus hookerii, Zhongguo Yaoxue... 

Jumpponen A, Spatial distribution of discrete RAPD phenotypes of a root endophytic fungus, Phialocephala fortinii, at a primary successional site on a glacier ioreiront, New Phytol 141 333-344, 1999. 

Wang S et ai, Chaetopyranin, a benzaldehyde derivative, and other related metabohtes from Chaetomium globosum, an endophytic fungus derived from the marine red Agp Polysiphonia urceolata, J Nat Prod 69 622— 62 y, 2006. 

Yang Ry et ai. Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities, BioorgMed Chem Lett 16 4205-4208, 2006. 

Davis RA et al, Phomoxins B and C Polyketides from an endophytic fungus of the genus Eupenicillium, Phytochemistry 66 2771—2775, 2005. 

Teles HL et ai, Benzopyrans from Curvularia sp., an endophytic fungus associated with Ocotea corymbosa (Lauraceae), Phytochemistry 66 2363-2367, 2005. 

Teles HL et ai, Aromatic compounds produced by Periconia atropurpurea, an endophytic fungus associated yt vila. Xylopia aromatica, Phytochemistry 67 2686-2690, 2006. 

Indcio ML et ai, Antifungal metabolites from Colletotrichum gloeosporioides, an endophytic fungus in Cryptocarya mandioccana Nees (Lauraceae), Biochem Syst Ecol 54 822-824, 2006. 

Silva GH et al., Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae), Phytochemistry 67 1964-1969, 2006. 

Pornpakakul S etai, Cytotoxic activity of four xanthones from EwcrzWZ color, an endophytic fungus isolated from Croton oblongifolius, Arch Pharmac Res 29 140-144, 2006. 

Marinho AMdR et al. Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach, J Brazil Chem Soc 16 280-283, 2005. 

Agusta A et al., Bisanthraquinone metabolites produced by the endophytic fungus Diaporthe sp, Chem Pharm Bull 54 579—582, 2006. 

AmnaT et al. Determination and quantification of camptothecin in an endophytic fungus by liquid chromatography-positive mode electrospray ionization tandem mass spectrometry, Curr Sci 91 208—212, 2006. 

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