Effect of immunoglobulin

The effect of immunoglobulin therapy is either protection against microorganisms (antibody substitution, passive immunization), or immunomodulation, or both. The mechanism of the response in non-infectious diseases is... 

Intravascular hemolysis is a rare adverse effect of immunoglobulins, due to the presence of anti-blood group antibodies (119-123). 

Adverse effects of immunoglobulin vary with the route of administration. Following IMIG, pain, tenderness, and muscle stiffness persisting for hours or days are common. Repeat courses may cause sensitization with resulting allergic reactions. With IVIG, adverse... 

C. Sautes, Cell-mediated Effects of Immunoglobulins, R. G. Landes Co., Austin, TX, 1997. 

Pandley J, Astemborski J, Thomas D L (2004). Epistatic effects of immunoglobulin GM and KM allotypes on outcome of infection with hepatitis C virus. J. Virol. 78 4561-4565. 

Major Reviews Recently excellent reviews have been published regarding the potential adverse effects of immunoglobulin therapy and the adverse haematologic effects of IVIG [Sl, 83 ]. 

Peters M, Waiting DM, Kelly K, Davis GL, Waggoner JG, Hoofnagle JH (1986) Immunologic effects of interferon-alpha in man treatment with human recombinant interferon-alpha suppresses in vitro immunoglobulin production in patients with chronic type B hepatitis. J Immunol 137 3147-3152... 

Hashimoto, Y., Sugawara, M., Masuko, T., and Hojo, H. (1983). Antitumor effect of actinomycin D entrapped in liposomes bearing subunits of tumor-specific monoclonal immunoglobulin M antibody. Cancer Res., 43, 5328-5334. 

Immunosera and human immunoglobulins depend for their protective effects on their content of antibodies derived, in the case of immunosera, flxm immunized animals and, in the case of immunoglobulins, flxm humans who have been immunized or who have high antibody titres consequent upon prior infection. This form of immunity, known as passive immunity, is achieved immediately but is limited in its duration to the time that protective levels of antibodies remain in the circulation see also Chapter 16. 

SAKUSHIMA J, NOSE M, OGiHARA Y (1997) Effect of hachimi-jio-gan on immunoglobulin A producing cells in Peyer s patch by oral administration. Biol Pharm Bull. 20 1175-7. 

Jyonouchi, H., Sun, S., and Gross, M., Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells astaxanthin, a carotenoid without vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent stimulant and antigen, Nutr. Cancer, 23, 171, 1994. 

Also known as antibody-mediated rejection, humoral rejection is the process of creating graft-specific antibodies.1,4 This type of rejection occurs less frequently than cell-mediated acute rejection. Humoral rej ection is characterized by deposition of immunoglobulins and complement in allograft tissues. Treatment for this type of rejection is not well defined, yet several reports have shown that treatments such as plasmapheresis, immunoglobulin therapy, rituximab, and/or antithymocyte globulin maybe effective. 

Bagchi, P., and Birnbaum, S.M. (1981) Effect of pH on the adsorption of immunoglobulin G on anionic poly(vinyltoluene) model latex particles./. Colloid Interface Sci. 83, 460 178. 

H.C.B. Graves, The effect of surface-charge on non-specific binding of rabbit immunoglobulin-G in solid-phase immunoassays. J. Immunol. Methods 111, 157—166 (1988). 

Jacobs, B. C., O Hanlon, G. M., Bullens, R. W. M., Veitch, J., Plomp, J. J. and Wilhson, H. J. Immunoglobulins inhibit pathophysiological effects of anti-CQlb-positive sera at motor nerve terminals through inhibition of antibody binding. Brain 126 2220-2234,2003. 

Mature B lymphocytes express AhR and ARNT,10,12 and the ability of TCDD to suppress primary antibody responses has been known for a long time (reviewed in4). While the precise mechanisms resulting in suppression of T-dependent B cell responses in vivo have not been fully elucidated, it is clear that direct effects of TCDD on B cells plays a role. Studies using two B cell lines with differential AhR expression have linked suppression of LPS-induced IgM production to AhR activation, and have shown that AhR interactions within the 3 alpha immunoglobulin heavy chain enhancer directly influence antibody production.52-54 TCDD also appears to directly modulate the expression of CD19 on human B cells, suggesting another mechanism by which TCDD down-modulates the responsiveness of mature B cells.55... 

Issues regarding the influence of duration or intensity of exposure in relation to effect on autoimmune disease processes are questions that have not been established, with some inconsistencies seen in the epidemiologic studies (Table 25.2). Dose or intensity of silica exposure affects the clearance from the lung and silica-containing macrophages can be translocated to pulmonary lymph nodes. Increased production of immunoglobulins and of lymphocyte-derived interferon-gamma is seen at these sites.49... 

Human health effects, of polychlorinated biphenyls, 13 140-142 Human IgG (hlgG), detection of, 14 155, 156. See also Immunoglobulin G (IgG) Human immunodeficiency virus (HIV). See also HIV entries Nevirapine entries inactivation of, 12 139 lactoferricins and, 18 258... 

---