Intravascular hemolysis

Jacobson et al. (1955) noted that the toxic actions of hydrazine and its methylated derivatives were similar all are respiratory irritants and convulsants. However, monomethylhydrazine also induced severe intravascular hemolysis in dogs. 

According to Jayle and Moretti (J12), human Hp combines with Hb from different species (monkey, horse, cow, dog, rabbit, and mouse). No difference has been found between the spectra of free Hb and Hp-bound Hb (G8, J12, R5). Spectroscopically the HpHb complexes gave the same CO, OH, and CN compounds as Hb. In intravascular hemolysis, methem-albumin forms only after Hp has been saturated with Hb, i.e., when small amounts of free Hb begin to appear in the plasma (A6, B14, L4,... 

The kidney is known to be particularly vulnerable to the toxic effects of heme and hemoglobin in disseminated intravascular hemolysis, and... 

The use of vincristine to treat thrombotic thrombocytopenic purpura has also been reported to be successful 14,18). This rare disease of sporadic thrombosis of small vessels with consequent intravascular hemolysis has been successfully treated recently with both plasma exchange and plasma infusion. However, there are obvious disadvantages to plasma infusion, including volume overload, transmission of infection, and cost and scarcity of plasma. Several patients have been successfully treated with vincristine alone or in association with plasma therapy. At present, however, this treatment should probably not be used alone because of the high success rate of plasma infusion and/or exchange. 

Algren J, Rodgers G, JR. 1992. Intravascular hemolysis associated with hydrocarbon poisoning. 

The development of intravascular hemolysis and anemia due to aniline-induced methemoglobinemia has been postulated, but neither is observed often in industrial practice, despite careful and prolonged study of numerous cases. Occasional deaths from asphyxiation caused by severe aniline intoxication are said to occur. The existence of chronic aniline poisoning is controversial, but some investigators have suggested that continuous exposure to small doses of aniline may produce anemia, loss of energy, digestive disturbance, and headache. ... 

Hassan AB, Hiseligmann H, Bassan PIM Intravascular hemolysis induced by pentachlorophenol. Br Med J 291 21-22, 1985... 

Chan TK, Mak LW, Ng RP. 1971. Methemoglobinemia, Heinz bodies and acutemassive intravascular hemolysis in Lysol poisoning. Blood 38 739-744. 

Summerlin et al. 1967). Acute copper intoxication is characterized by hemolytic anemia with intravascular hemolysis (Summerlin et al. 1967)... 

Fig. 12.20 Consequences of intravascular hemolysis in rats receiving graded doses of DS-96 i.p. daily for five days...

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