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Database toxic chemical data

Hazardous Substances Data Bank (HSDB) on compact disc from the Canadian Center for Occupational Health and Safety (can buy at CCOHS web site). "The HSDB(R) (Hazardous Substances Data Bank(R)) database contains data profiles on 4,500 potentially toxic chemical substances. It is created and updated by specialists at the U.S. National Library of Medicine. Compiled from an extensive range of authoritative sources, HSDB is widely recognized as a reliable and practical source of health and safety information. Much of the data is peer reviewed. [Pg.185]

The USEPA must establish and inainlain a national toxic chemical inventory based on all Ihc release data submitted, wltich must be accessible by computer on a national database. [Pg.67]

According to the Toxic Chemical Release Inventory database (TRl), an estimated total of at least 49 million pounds of trichloroethylene was released to air from manufacturing and processing facilities in the United States in 1988 (TRI88 1990). The level reported in 1993 was 30.2 million pounds (TRI93 1995). The number of reporting facilities in each state and the ranges within which individual facilities reported their releases are shown in Table 5-1. The TRI data listed in this table should be used with caution since only certain types of facilities are required to report. This is not an exhaustive list. [Pg.204]

Although this section does not present historical information regarding TRI chemical releases over time, note that, in general, toxic chemical releases have been declining.13 Although onsite releases have decreased, the total amount of reported toxic waste has not declined because the amount of toxic chemicals transferred offsite has increased. Better management practices have led to increases in offsite transfers of toxic chemicals for recycling. More detailed information can be obtained from U.S. EPA s annual Toxics Release Inventory Public Data Release book, or directly from the Toxic Release Inventory System database. [Pg.135]

AntiBase 2005 is a comprehensive database of 31 022 natural compounds from micro-organisms and higher fungi based on curated literature reports. In addition to descriptive chemical data, biological data (e.g. pharmacological activity, toxicity) and information on origin and isolation are included. [Pg.5]

The order of procedures that result in the publication of an EHC monograph is shown in the flow chart on the next page. A designated staff member of IPCS, responsible for the scientific quality of the document, serves as Responsible Officer (RO). The IPCS Editor is responsible for layout and language. The first draft, prepared by consultants or, more usually, staff from an IPCS Participating Institution, is based initially on data provided from the International Register of Potentially Toxic Chemicals and from reference databases such as Medline and Toxline. [Pg.204]

Figure 13.1 Correlation between rat LD50 and mouse LD50 values (mg kg ) for 392 chemicals included in the EPA s Toxic Release Inventory list of toxic chemicals which have acute toxicity data (LD50s) reported in the EPA ACToR database [3]. Figure 13.1 Correlation between rat LD50 and mouse LD50 values (mg kg ) for 392 chemicals included in the EPA s Toxic Release Inventory list of toxic chemicals which have acute toxicity data (LD50s) reported in the EPA ACToR database [3].
Another typical source of uncertainty in mixture assessment is the potential interaction between substances. Interactions may occur in the environment (e.g., precipitation after emission in water), during absorption, transportation, and transformation in the organism, or at the site of toxic action. Interactions can be either direct, for example, a chemical reaction between 2 or more mixture components, or indirect, for example, if 1 mixture component blocks an enzyme that metabolizes another mixture component (see Chapters 1 and 2). Direct interactions between mixture components are relatively easy to predict based on physical-chemical data, but prediction of indirect interactions is much more difficult because it requires detailed information about the processes involved in the toxic mechanisms of action. One of the main challenges in mixture risk assessment is the development of a method to predict mixture interactions. A first step toward such a method could be the setup of a database, which contains the results of mixture toxicity tests. Provided such a database would contain sufficient data, it could be used to predict the likelihood and magnitude of potential interaction effects, that is, deviations for CA and RA. This information could subsequently be used to decide whether application of an extra safety factor for potential interaction effects is warranted, and to determine the size of such a factor. The mixture toxicity database could also support the search for predictive parameters of interaction effects, for example, determine which modes of action are involved in typical interactions. [Pg.204]

RTECS, compiled by NIOSH (U.S. National Institute for Occupational Safety and Health), is a comprehensive database of basic toxicity information and toxic-effects data on more than 100,000 chemicals. [Pg.70]

This database contains toxicological data on over 850 chemicals of particular interest to the United States Great Lakes basin. Each record provides descriptive data on up to 23 topic areas, including physical and chemical properties, toxicity, and environmental fate. Produced by the Michigan Department of Natural Resources and the Ontario Ministry of the Environment. Fully evaluated and referenced data. (CCINFOline contained in CCINFOdisc CHEMpendium series from CCOHS) Chemical Safety Newsbase (CSNB) ... [Pg.1431]

Contains toxic effects data (with citations) on over 157 000 chemicals identified by NIOSH and mandated by the Occupational Safety and Health Act of 1970. Acute and chronic effects, selected regulatory information, lARC reviews, TSCA status, GENE-TOX data, and NTP documents cited. Data selectively included, not comprehensive. This database is compiled, maintained, and updated by MDL Information Systems, Inc., under the authority of the US government (CIS, Data-Star, DIALOG, DIMDI, STN CD version contained in CCINFOdisc Core Series C2 from CCOHS and CHEMBANK from Silver Platter). [Pg.1434]

TRI is an annually compiled series of databases spanning the reporting years 1987-2001, and which contains information on the annual estimated releases of toxic chemicals to the environment. It is based upon data collected by the US EPA. Mandated by the Superfund legislation, TRI s data cover air, water, land, and underground injection releases, as well as transfers to waste sites, and waste treatment methods and efficiency, as reported by industrial facilities in the United States. TRI also includes data related to source reduction and recycling. [Pg.2937]

TOXMAP is a Web resource that uses maps of the United States to show the amount and location of toxic chemicals released into the environment. Data are derived from the TRI database (described above), which provides information on toxic releases into the environment as reported by US industry. TOXMAP helps users create nationwide or local area maps showing where chemicals are released into the air, water, and ground. It also identifies the releasing facilities, color-codes release amounts for a single year, and provides multi-year chemical release trends, starting with 1987. Users can search the system by chemical name, chemical name fragment, and/or location (such as city, state, or zip code). TOXMAP also overlays map data such as US Census population data. [Pg.2939]

This book is a tool for the legal, medical, scientific and political professions and should not be misconstrued as a cookbook . Publisher and author take no responsibility for inaccuracies, omissions, or typographical errors. References and sources are included for those seeking unedited detailed descriptions on the construction of any specific molecule. All chemicals and reactions are potentially toxic, explosive lethal. Check NTP and OSHA databases for toxicology data. [Pg.191]

ChemSpider currently searches over 14 million compounds in multiple chemical structure databases. These include databases of curated literature data, chemical vendor catalogs, molecular properties, enviromnental data, toxicity data, analytical data, and so on. ChemSpider intends to aggregate into a single database all chemical structures available within open access and commercial databases and to provide the necessary pointers from the ChemSpider search engine to the information of interest. This service will allow users to either access the data immediately via open-access links or have the information necessary to continue their searches into commercially available systems. [Pg.257]

The process starts with a database search to determine whether human health information, ecological toxicity data, or chemical data exist on the C R material of interest (Fig. 7). If data are unavailable, the user requests toxicity screening tests (algae and daphnia were the primary aquatic indicators used in this study). If the test results show no toxicity, no further investigation is required. If the screening tests results show toxicity, the user requests tests for evaluating the source strength and effects of reference environments on toxicity response, and chemistry. [Pg.152]

As depicted in Fig. 2, the process starts with a database search to determine whether human health information, ecological toxicity data, or chemical data exist on the subject C R material. [Pg.275]

It is hosted by Environmental Protection Agency (EPA) USA to predict the toxicity of compounds [57], It encourages andnses the stmctnre datafile (sdf) format. It has a browser developed from open-source tools to search its data files. The files can be downloaded into any chemical relational database for chemical analog searching to enable model building (Fig. 2.15). [Pg.110]

EPCRA section 313 requires certain covered facilities that have ten or more employees and that manufacture, process, or use specified chemicals in amounts greater than threshold quantities, to submit an annual toxic chemical release report. This report, commonly known as the TRI Form R, covers releases and transfers of toxic chemicals to various facilities and environmental media. EPA maintains the data reported in a publically accessible database known as the Toxics Release Inventory (TRI). Note that oil and gas extraction facilities are currently exempted from TRI reporting. [Pg.551]

JECDB Database of chemical toxicity provided by Ministry of Health, Labour and Welfare, Japan. It contains reports of toxicological tests of compounds in the environment http //dra4.nihs.go.jp/mhlw data/jsp/SearchPageENG.jsp... [Pg.333]


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