Cutaneous wounds

Anthony ET, Syed M, Myers S, Moir G, Navsaria H (2006) The development of novel dermal matrices for cutaneous wound repair. Drug Discov Today Ther Strateg 3(l) 81-86... 

Shukla A, Rasik A, Patnaik M (1997) Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defense enzymes in healing cutaneous wounds. Free Radic Res 26(2) 93-101... 

Brown LF, Dubin D, Lavigne L et al (1993) Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound-healing. Am J Pathol 142(3) 793-801... 

Bradshaw, A., Reed, M., Sage, E. (2002). SPARC-null mice exhibit accelerated cutaneous wound closure. J. Histochem. Cytochem. 50 1-10. Erratum in J. Histochem. Cytochem. 50 875. 

Kane, C. J., Hebda, P. A., Mansbridge, J. N., and Hanawalt, P. C., Direct evidence for spatial and temporal regulation of transforming growth factor (31 expression during cutaneous wound healing, J. Cell Physiol., 148, 157, 1991. 

Altman et al. utilized a composite silk fibroin/chitosan scaffold for seeding and in vivo delivery of human ADSCs in a murine cutaneous wound model, and the delivery technique conferred physiological benefits to accelerated wound closure. ADSC seeded on a silk fibroin/chitosan scaffold differentiated into fibrovascular, endothelial, and epithelial components of restored tissue and enhanced the wound healing process [219]. 

W. K. Stadelmann, A. G. Digens, and G. R. Tobin Physiology and healing dynamics of chronic cutaneous wounds. American Journal of Surgery 176(Suppl. 2A), 265 (1998). 

MONITORING OF COLONIZATION AND CLEARANCE OF LIGHT-EMITTING BACTERIA FROM TUMORS, CUTANEOUS WOUNDS, AND INFLAMMATORY SITES IN LIVE ANIMALS... 

Bacterial colonization of cutaneous wounds in mice was eliminated upon wound healing. Cutaneous wounds were induced in nude mice by preparing a 5 mm long incision in the femoral region, which was then closed with sutures. A wound was also created by puncturing the mouse ear with ear tags. Bacteria were... 

This study showed that a minimal number (1x10 - 1(F) of i.v. injected bacteria is required to achieve entry and replication in tumors of a predetermined developmental stage. On the other hand, in cutaneous wounds, the survival and replication of i.v. injected bacteria was transient and the bacteria were cleared in 7-10 days after injection. In contrast, at artificially induced inflammatory sites in a tumor-bearing mouse, no survival and replication of bacteria was observed. 

Woodley DT, O Keefe EJ and Prunieras M (1985). Cutaneous wound healing a model for cell-matrix interactions. J Am Acad Dermatol, 12, 420. 

I.-G. Rojas et al., Stress-induced susceptibility to bacterial infection during cutaneous wound healing, Brain, Behaviour and Immunity, 16, 2002, 74-84. 

Badiavas EV, Abedi M, Butmarc J, Falanga V, Quesenberry P. Participation of bone marrow derived cells in cutaneous wound healing. 

Jarvelainen H, Puolakkainen P, Pakkanen S, Brown EL, Hook M, lozzo RV, Sage EH, Wight TN. A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen 2006 14 443-452. 

These two reports 10 years apart reflect the continuing interest in heparin combinations playing a multifactorial role in wound healing. The role of heparin alone has also received considerable attention. Considerable research has looked at the role of heparin in anticoagulation but in the context of cutaneous wound healing the focus is on topical application. 

There is no doubt that carbohydrates play multiple and complex roles in the process of cutaneous wound healing. This chapter has been able to give only an overview of some of these roles and in many cases the mechanisms of action and effect are still in the process of being elucidated. 

GillitzerR, GoebelerM Chemokines in cutaneous wound healing. JLeukoc Biol 2001 69 513-521. Jones SA, Wolf M, Qin S, Mackay CR, Baggiolini M Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. Proc Natl Acad Sci USA 1996 93 6682-6686. 

A7. Arumugam, S., Jang, C., Chen-Jensen, C., Gibran, N. S., and Isik, F. F., Temporal activity of plasminogen activators and matrix metalloproteinases during cutaneous wound repair. Surgery 125, 587-593 (1999). 

Sen, C.K., Khanna, S., Babior, B.M., Hunt, T.K., Ellison, E.C., and Roy, S., Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing, J. Biological Chem., 277, 33284-33290, 2002. 

Esimone CO, Nworu CS, Jackson CL (2008) Cutaneous wound healing activity of a herbal ointment containing the leaf extract of Jatropha curcas L. (Euphorbiaceae). Int J Appl Res Nat Prod 1 1-4... 

Schrementi, M., Ferreira, A., Zender, C., and DiPietro, L. (2008) Site-specific production of TGF-beta in oral mucosal and cutaneous wounds. Wound Repair and Regeneration, 16, 80-86. 

---