Temporal regulation

Beermann, F., Schmid, E., and Schtitz, G. (1992a). Expression of the mouse tyrosinase gene during embryonic development recapitulation of the temporal regulation in transgenic mice. Proc. Natl. Acad. Sci. USA 89 2809-2813. 

B. H. Junker, R. Wuttke, A. Tiessen, P. Geigenberger, U. Sonnewlad, L. Willmitzer, and A. R. Fernie, Temporally regulated expression of a yeast invertase in potato tubers allows dissection of the complex metabolic phenotype obtained following its constitutive expression. Plant Mol. Biol. 56, 91 110 (2004). 

Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA, Herrera RE (2003) The dynamic mobility of histone HI is regulated by cyclin/CDK phosphorylation. Mol Cell Biol 23(23) 8626-8636 Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P (2002) Mitotic phosphorylation of histone H3 spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol 22(3) 874-885... 

Since the enzyme that is most specific in the ubiquitin-conjugation reaction, E3, is also highly regulated, temporal regulation of ubiquitination is easily achieved. For example, if a given E3 is activated by a protein kinase, activation of the E3 is tied to the stimulation of the kinase. For example, phosphorylation activates the ARC ubiquitin ligase. An interesting example is that of serum-inducible kinase (SNK). SNK stimulates... 

A detailed protocol for the generation of genetically modified human xenograft mouse models in which the knockdown of a putative oncology target is temporally regulated in vivo using a tetracycline inducible system is found in this book (17). 

Lee B., Butcher G. Q., Hoyt K. R., Impey S., and Obrietan K. (2005a). Activity-dependent neuroprotection and cAMP response element-binding protein (CREB) kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133. J. Neurosci. 25 1137-1148. 

Bergh JJ, Shao Y, Puente E, Duncan RL, Farach-Carson MC. 2006. Osteoblast Ca2+ permeability and voltage-sensitive Ca2+ channel expression is temporally regulated by 1,25-dihydroxyvitamin D3. Am J Physiol 290 C822-31. 

Hayashi, S. and McMahon, A. P. (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre a tool for temporally regulated gene activa-tion/inactivation in the mouse. Dev Biol244, 305-318. 

A, Paul P, Gangadharan U, Hobbs C, Di Marzo V, Doherty P (2003) Cloning of the first sn 1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signalling in the brain. J Cell Biol 163 463-8... 

The expression of RNA aptamers needs to be at sufficiently high levels within cells in order to influence their phenotype and alter target protein function in its cellular environment. One potential disadvantage of intracellu-larly expressed aptamers is that once the aptamer is expressed in the cell and the target protein inhibited, there is no further possibility of precise control of the aptamer s action [33]. Temporal regulation of the aptamer s activity may be crucial if the inhibition of a target protein is desired... 

Ono T, et al. Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. Mol. Biol. Cell. 2004 15 3296-3308. 

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