Conjugated linoleic acids metabolic effects

Gnadig, S. (2002). Conjugated linoleic acid (CLA) Effect of processing on CLA in cheese and the impact of CLA on the arachidonic acid metabolism (thesis). University of Hamburg, 170pp. 

Field, CJ. and Schley, P.D., Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function lessons from n-3 fatty acids, Am. J. Clin. Nutr., 79, 1190S, 2004. 

Noone, E.J., Roche, H.M., Nugent, A.P., Gibney, M.J. 2002. The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br. J. Nutr. 88, 243-251. 

Urquhart, P., Parkin, S.M., Rogers, J.S., Bosley, J.A., Nicolaou, A. 2002. The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. Biochim. Biophys. Acta 1580, 150-160. 

Igarashi M, Miyazawa T. (2001) The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell hne, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of hpid peroxidation in the cells. Biochim Biophys Acta 1530 162-171. 

Effects of Conjugated Linoleic Acid Isomers on Obesity and Lipid Metabolism in Obese Rats... 

Sugano, M., Tsujita, A., Yamasaki, M., Yamada, K., Ikeda, L, and Kritchevsky, D. (1997) Lymphatic Recovery, Tissue Distribution, and Metabolic Effects of Conjugated Linoleic Acid in Rats, 7. Nutr. Biochem. 8, 38 3. 

Fig. 5. Effects of c9,f11 -conjugated linoleic acid (CLA) and 10 12c-CLA on energy metabolism in OLETF rats. Rats were fed the c9,f11 -CEA diet or the f10,c12-CLA diet for 10 d. Significantly different from 9c,1 M, P< 0.05.

West,D.B.,Delany,J.P.,Carnet, P.M., Blohm,F.,Truett,A.A., and Scimeca, J. A. (1998) Effects of Conjugated Linoleic Acid on Body Fat and Energy Metabolism in the Mouse, Am. J. Physiol. 275, R667-R672. 

Martin, J.C., Gregoire, S., Siess, M.H., Genty, M., Chardigny, J.M., Bordeaux, O., Juaneda, P., and Sebedio, J.-L. (2000) Effects of Conjugated Linoleic Acid Isomers on Lipid-Metabolizing Enzymes in Male Rats, Lipids 35,91-98. 

Effects of Short-Term Administration of Conjugated Linoleic Acid on Lipid Metabolism in White and Brown Adipose Tissues of Starved/Refed Otsuka Long-Evans Tokushima Fatty Rats, Food Res. Int. 34 515—520 (2001). 

Recovery, Tissue Distribution, and Metabolic Effects of Conjugated Linoleic Acid in Rats. L Nutr. Biochem. 8 38-43 (1997). 

Effect of Conjugated Linoleic Acid Role of Metabolic Rate. /. Nutr. 131 2067—2068... 

Igarashi, M., and T. Miyazawa. The Growth Inhibitory Effect of Conjugated Linoleic Acid on a Human Hepatoma Cell Line, HepG2, is Induced by a Change in Fatty Acid Metabolism, but not the Facilitation of Lipid Peroxidation in the Cells, Biochim. Biophys. Acta 1530 162-171 (2001). 

Kamphuis M.M., M.P. Lejeune, W.H. Saris, M.S. Westerterp-Plantenga. The Effect of Conjugated Linoleic Acid Supplementation After Weight Loss on Body Weight Regain, Body Composition, and Resting Metabolic Rate in Overweight Subjects, lnt.1 Obes.Relat Metab. Disord. 27 840-847 (2003). 

Baumgard, L.H., Corl, B.A., Dwyer, D.A., and Bauman, D.E. (2002) Effects of Conjugated Linoleic Acids (CLA) on Tissue Response to Homeostatic Signals and Plasma Variables Associated with Lipid Metabolism in Lactating Dairy Cows, J. Anim. Sci. 80, 1285-1293. 

Effects of Conjugated Linoleic Acid on Body Fat and Energy Metabolism in the Mouse, Am. J. Physiol. 275, R667-R672. 

Teipstra, A.H.M. (2001) Differences Between Humans and Mice in Efficacy of the Body Fat Lowering Effect of Conjugated Linoleic Acid Role of Metabolic Rate, J. Nutr. 131, 2067-2068. 

There are two known biologically active isomers of conjugated linoleic acid (CLA) c9, llCLA, the most prevalent CLA isomer in the diet, and tl0,cl2 CLA, which appears to induce most of the known physiologic effects attributed to CLA, particularly as they relate to fat storage and metabolism (1,2). Important examples are the inhibition of body fat accretion seen in many animal species fed diets containing CLA, and inhibition of milk fat synthesis in dairy cows, effects that are induced by the tl0,cl2 CLA isomer (3-5). 

Smedman, A., and Vessby, B. (2001) Conjugated Linoleic Acid Supplementation in Humans—Metabolic Effects, Lipids 36, 773-781. 

Henriksen, E.J., Teachey, M.K., Taylor, Z.C., Jacob, S., Saengsirisuwan, V., Kramer, K., Klatt, M.J., Ptock, A., and Hasselwander, O. (2002) Metabolic Effects of Conjugated Linoleic Acid on Insulin Resistant Rat Skeletal Muscle Glucose Transport Are Isomer Specific, Diabetes 51, A309 (Abstr.). 

Conjugated linoleic acid has pronounced effects on energy expenditure, lipid metabolism, and body composition of animal models. However, there are still insufficient data to determine whether CLA has the same biological effects in humans. Data from the randomized, controlled trials clearly demonshate that if... 

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