Combination products containing

Animal uses employ resin in various stabilized forms at levels of 200,000 400,000 500,000 and 1 x 10 units of per gram. Combination products containing A and D are also available, with 650,000 units of vitamin A and 325,000 units vitamin D per gram of product being the most common dosage form. 

Salmeterol is also available in a fixed ratio combination product containing fluticasone, and a new drug application has been filed for a fixed combination product containing budesonide and formoterol. Combination products have the potential advantage of increasing patient adherence due to the decreased number of inhalers and inhalations however, these products offer less flexibility with respect to dosage adjustments when necessary. 

Ryan [36] developed a method to determine the relative degree of crystallinity (RDC) of imipenem in lypophilized combination products containing imipenem and amorphous cilastatin sodium. He used the relationship... 

Zegerid is a combination product containing omeprazole 20 or 40 mg with sodium bicarbonate in immediate-release oral capsules and powder for oral suspension. It should be taken on an empty stomach at least 1 hour before a meal. Zegerid offers an alternative to the delayed-release capsules or the IV formulation in adult patients with nasogastric tubes. 

A combination product containing albuterol and ipratropium (Combi-vent) is available as an MDI for chronic maintenance therapy of COPD. Other similar combination products may become available in the future. 

Lamivudine (3TC, Epivir) is a cytosine nucleoside analogue with activity against HIV-1, HIV-2, and hepatitis B virus. It is approved as part of a multidrug regimen for the therapy of HIV infection in adults and children and has been used for HIV postexposure prophylaxis. Combination products contain lamivudine with either zidovudine (Combivir) or zidovudine and abacavir (Trizivir). The use of low-dose lamivudine in the treatment of chronic hepatitis B is described in Chapter 50. 

Contraindications Hypersensitivity to buprenorphine hypersensitivity to naloxone for those receiving the fixed combination product containing naloxone (Suboxone)... 

CASE STUDY 3 HPLC PURITY METHOD DEVELOPMENT CHALLENGES FOR A FIXED COMBINATION PRODUCT CONTAINING A LOW-DOSE ACTIVE INGREDIENT AND A HIGH-DOSE ACTIVE INGREDIENT... 

Sterile radiopharmaceuticals may be divided into those which are manufactured aseptically and those which are terminally sterilized. In general, it is advisable to use a terminal sterilization whenever this is possible. Terminal sterilization is defined as a process that subjects the combined product/container/closure system to a sterilization process that results in a specified assurance of sterility [7], Since sterilization of solutions normally means autoclaving (steam sterilization), one must assure that the radiopharmaceutical product does not decompose when it is heated to temperatures above 120°C. Many radiolabeled compounds are susceptible to decomposition at higher temperatures. Proteins, such as albumin, are good examples of this. Others, such as 18F-fluodeoxyglucose (FDG), can be autoclaved in some formulation but not in others. 

A combination product containing oestrogen and progestogen should be used if the patient has an intact uterus. 

Used in mild-to-moderate pain May use in conjunction with opioid agents to decrease doses ot each Regular alcohol use and high doses of acetaminophen may result in liver toxicity Care must be exercised to avoid overdose when combination products containing these agents ate used Drug ot choice in severe pain Use immediate-release product with SR product to control breakthrough pain in cancer patents... 

A combination product containing approved active ingredients. 

The administration of ginseng has also been studied in the treatment of attention-deficit hyperactivity disorder (ADHD). Lyon et al., conducted a pilot study (n = 36) evaluating the effects of a combination product containing ginseng and ginkgo for the treatment of ADHD (44). The investigators reported improvement in 31-67% of the subjects depending on the outcome measure however, no placebo control was included, so it is difficult to ascertain if the effect was caused by the treatment or a placebo effect. 

Most proprietary OTC oral analgesics are not simple formulations of aspirin, ibuprofen or paracetamol, but combination products containing other analgesics and sometimes other constituents. 

Migraine can often be treated with paracetamol, ibuprofen or aspirin alone, or with combination products containing them. There are also some non-prescription medicines specifically licensed for the treatment of migraine. One such is a coformulation of paracetamol, codeine and the antihistamine buclizine, included for its antiemetic action. Other specific migraine treatments are reviewed below. 

Anxiolytic effects have been demonstrated in animal models. The effect of Zingicomb (Mattem et Partner, Starnberg, Germany), a combination product containing 24% ginkgo flavonoids and 23.5% gingerols, administered... 

Several combination products contain coltsfoot. Hormone Rejuvenator is a capsule containing bilberry bark, cascara sagrada, chamomile, chickweed, coltsfoot, comfrey root, dandelion root, golden seal root, hyssop, juniper berries, licorice root, and wild cherry bark. Respiratory Rejuvenator contains pleurisy root, horehound, lobelia, fenugreek, eucalyptus, coltsfoot, comfrey, mullein, lady slipper, marshmallow, white pine bark, myrrh, and hyssop. Alvita Teas, Herb Pharm, and Nature s Answer are all manufacturers that provide coltsfoot products. 

Comfrey is currently promoted for prevention of kidney stones, for treatment of rheumatic and pulmonary disorders, and for treatment of injuries such as burns and bruises. Combination products containing comfrey for internal use are promoted for nourishing and repairing bone and muscle. Several cosmetic products contain comfrey and claim to remove excess oil from the skin, as well as to moisturize and exfoliate dry skin. 

---