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Development challenge

Karim A. A., Bhat R. 2008. Gelatin alternatives for the food industry recent developments, challenges and prospects. Trends in Food Science Technology 19, 644-656. [Pg.113]

At present, new developments challenge previous ideas concerning the role of nitric oxide in oxidative processes. The capacity of nitric oxide to oxidize substrates by a one-electron transfer mechanism was supported by the suggestion that its reduction potential is positive and relatively high. However, recent determinations based on the combination of quantum mechanical calculations, cyclic voltammetry, and chemical experiments suggest that °(NO/ NO-) = —0.8 0.2 V [56]. This new value of the NO reduction potential apparently denies the possibility for NO to react as a one-electron oxidant with biomolecules. However, it should be noted that such reactions are described in several studies. Thus, Sharpe and Cooper [57] showed that nitric oxide oxidized ferrocytochrome c to ferricytochrome c to form nitroxyl anion. These authors also proposed that the nitroxyl anion formed subsequently reacted with dioxygen, yielding peroxynitrite. If it is true, then Reactions (24) and (25) may represent a new pathway of peroxynitrite formation in mitochondria without the participation of superoxide. [Pg.698]

There are other clinical drug development challenges. Evaluating dose-response Are there better methods for evaluating dose-response How do we make the regulations make sense so that people feel comforfable doing this work ... [Pg.614]

Given the abundance of water-insoluble or poorly water-soluble drugs as well as drugs exhibiting other development challenges such as metabolic and enzymatic instability, the pharmaceutical industry continues to seek solutions to overcome these limitations to develop innovative, clinically safe, and patient-friendly products. As said earlier, MR delivery products offer tremendous advantages with respect to therapeutic indices, pharmacoeconomics, and patient compliance. In addition,... [Pg.631]

The PK/PD properties of ASOs provide a framework for rapid drug development. Challenges to the promise of antisense therapeutics are not unlike those for any other new chemical entity, and they include proper application of the pharmacokinetic properties in order to select both target and delivery methods. The profound difference from the situation of small molecule discovery is the relative predictability of the pharmacokinetics, independent of target selection. [Pg.115]

ANALYTICAL METHOD DEVELOPMENT CHALLENGES AND SOLUTIONS FOR LOW-DOSE ORAL DOSAGE FORMS... [Pg.241]

CASE STUDY 3 HPLC PURITY METHOD DEVELOPMENT CHALLENGES FOR A FIXED COMBINATION PRODUCT CONTAINING A LOW-DOSE ACTIVE INGREDIENT AND A HIGH-DOSE ACTIVE INGREDIENT... [Pg.250]

CASE STUDY 3 HPLC PURITY METHOD DEVELOPMENT CHALLENGES 251... [Pg.251]

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See also in sourсe #XX -- [ Pg.231 , Pg.232 , Pg.233 , Pg.234 , Pg.235 ]



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