Decreased doses

Decrease dose in patients with hepatic impairment. 

Decrease dose in patients with renal impairment. Read package insert before use... 

Decrease dose or change corticosteroid to one with less mineralocorticoid activity (e.g., dexamethasone)... 

Entacapone (Comtan ) Peripherally blocks COMT metabolism of DA Take a 200-mg tab with each Sinemet dose up to 8 tabs daily usual MD is 200 mg 3-4 times daily decrease dose by 50% with hepatic impairment... 

Amantadine (Symmetrel ) NMDA-receptor antagonist that blocks glutamate transmission, promotes DA release, and blocks Ach Start with 1 00 mg daily at breakfast after 1 week, add 1 00 mg daily in the early afternoon decrease dose as creatinine clearance decreases less than... 

Decrease dose and increase frequency of standard Sinemet ... 

Decrease dose by 25% each day (or less if patient does... 

Prophylaxis Nystatin, clotrimazole, Inhibit P-450 3A4 monitor CSA and TAC levels decrease doses... 

It is important to update the bronchial dosimetry for radon daughters as new information becomes available. It is the purpose of this study to show that there is a potential for either significantly increased bronchial dose in the home per unit exposure if the ambient particle size is artificially reduced due, for example, to open-flame burning or use of kerosene heaters, or a decreased dose if hygroscopic particles dominate the indoor aerosol. 

Topotecan—hold for ANC < 1500 or platelets < 100,000 decrease dose by 0.25 mg/M2/d for prior episode of severe neutropenia or administer G-CSF starting on day 6... 

Usual maintenance dose for atrial fibrillation is 200 mg/day (may further decrease dose to 100 mg/day with long-term use if patient clinically stable in order to decrease risk of toxicity) usual maintenance dose for ventricular arrhythmias is 300-400 mg/day. 

Decrease dose in patient with renal impairment and in the elderly... 

Decreasing doses in standard regimens should be avoided unless necessitated by severe toxicity. 

Too high 20 to 25 mcg/mL Decrease doses by 10%. Recheck serum theophylline concentration after 3 days.-... 

MAO inhibitors Consider decreased doses of sumatriptan in patients receiving MAO inhibitors. 

Anxiety disorders (immediate-release and intensol) - Initial dose is 0.25 to 0.5 mg 3 times/day. Titrate to max total dose of 4 mg/day in divided doses at intervals of 3 to 4 days. If side effects occur with starting dose, decrease dose. Panic disorder (Xanax, Xanax XR, and Niravam) -... 

Start with 14 mg/day for 6 weeks for patients who smoke less than 10 cigarettes/day. Decrease dose to 7 mg/day for the final 2 weeks. 

Dosage in renal impairment Decrease dose to 25% of normal... 

Hereditary angioedema PO Initially, 200 mg 2-3 times/day. Decrease dose by 50% or less at 1-3 mo intervals. If attack occurs, increase dose by up to 200 mg/day. 

Hemat ocrit/hemoglobin weekly for 4 wk or until stable if Hb increases > 1. Og/dLin any 2-wk period, decrease dose (possible increased seizure risk) target Hb level to not exceed 12 g/L... 

Syndrome of inappropriate ADH secretion (SIADH) PO Initially, 900-1200 mg/day in 3-4 divided doses, then decrease dose to 600-900 mg/day in divided doses. 

Withold dosage temporarily if severe adverse reaction occurs consider decreasing dose to 7.5 meg... 

Hypoparathyroidism IV 0.04-0.1 mcg/kg (2.8-7 meg) given as a bolus dose no more frequently than every other day at anytime during dialysis dose as high as 0.24 mcg/kg (16.8 meg) has been administered safely. Usually start with 0.04 mcg/kg 3 times/week as a bolus, increased by 0.04 mcg/kg every 2 weeks. Adjust dose based on serum PTH levels. Same or increasing serum PTH level. Increase dose. Serum PTH level decreased by <30% Increasedose. SerumPTHleveldecreasedby >30%and <60% Maintaindose. Serum PTH level decreased by >60% Decrease dose. Serum PTH level 1.5-3 times upper limit of normal Maintain dose. 

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