Cascara sagrada

Cascade control Cascade cycles Cascading Cascara sagrada Cascarine CA Search... 

Ca.sca.ra. Sagrada. Cascara sagrada, also known as sacred bark, chitten, dogwood, coffeeberry, bearberry, bitter bark, and bearwood, is the dried bark of Jdamnus Purshiana DeCandoUe. It is ia the form of browa, purpHsh browa, or brownish red flattened or transversely curved pieces, 1- to 5-mm thick, and has a characteristic odor and bitter taste. It should be collected at least one year prior to use. The active constituents are aloe-emodin... 

Cascara sagrada is used as a cathartic. It is most useful when prepared as a fluid extract, and tends to be a mild laxative causing Htfle discomfort. However, on prolonged use it may result in characteristic melanotic pigmentation of the rectal mucosa. The bitter taste can be lessened, owing to neutralization of the acid constituents, if the ground substance is moistened and mixed with magnesium or calcium hydroxide. This treatment may lessen the potency of the preparation. 

Sagradarlnde, /. cascara sagrada. saJa, pret. (of sehen) saw. 

Irritant or stimulant laxatives increase peristalsis by direct action on the intestine. An example of an irritant laxative is cascara sagrada and senna (Senokot). 

Cascara sagrada or senna—Pink-red, red-violet, red-brown, yellow-brown, or black discoloration of urine may occur. 

DDS 100 Plus Capsules—docusate, casanthranol Doxidan Capsules—docusate, casanthranol, sorbitol Nature s Remedy—cascara sagrada, aloe, lactose Peri-Colace—docusate, casanthranol, sorbitol, parabens Senokot-S tablets—docusate, senna concentrate, lactose... 

Cascara sagrada Dose varies with formulation... 

The answer is c. (Hardman, p 924.) Dioctyl sodium sulfosuccinate (docusate) is a detergent that, when given orally, softens the stool and prevents straining. Mineral oil also softens the stool, but it tends to inhibit the absorption of fat-soluble vitamins and other nutrients. Castor oil, phenol-phthalein, and cascara sagrada are strong laxatives and cause watery stools... 

Melanosis coll Melanosis coll is a darkened pigmentation of the colonic mucosa resulting from chronic use of anthraquinone derivatives (casanthrol, cascara sagrada, senna). 

Lactation Anthraquinone derivatives (eg, casanthranol, cascara sagrada, danthron) are excreted in breast milk resulting in a potential increased incidence of diarrhea in the nursing infant. Sennosides A and B (eg, senna) are not excreted in breast milk. It is not known whether docusate calcium, docusate potassium, docusate sodium, lactulose, and mineral oil are excreted in breast milk. 

Cascara Sagrada [Rhamnus purshiana) Uses Laxative Action Stimulates large intestine, T bowel motility propulsion Available forms Liq extract 1-5 mL PO OD Contra w/ PRG, lactation IBD Notes/SE N/V, abd cramps, urine discoloration, osteomalacia Interactions t Effects OF antiarrhyth-mics, cardiac glycosides T loss W/ diuretics, corticosteroids, cardiac glycosides effects W/ antacids, milk EMS Short-term use monitor ECG for hypokalemia (flattened T waves) d/t D caution w/ diuretics... 

Anthraquinone derivatives (e.g., cascara, aloe, senna, and rhubarb) are among the oldest laxatives known. They act on the colon rather than on the ileum and produce evacuation 8 to 10 hours after administration. This makes them particularly suitable for dosage overnight. Cascara sagrada is one of the mildest of the anthraquinone-containing laxatives. 

OTC Aromatic Cascara Fluid extract, Cascara Sagrada, Cascara Aromatic Chemical Class Anthraquinone derivative... 

Do not use cascara sagrada if abdominal pain, nausea, or vomiting lasting longer than 1 wk occurs... 

OTC with senna concentrate (Senokot-S) with phenolphthalein (Doxidan) with casanthranol (Peri-Colace) with cascara sagrada (Nature s Remedy)... 

Long-term use of stimulant laxatives bisacodyl (Dulcolax), cascara sagrada, and Neoloid except in the presence of opiate analgesic use May exacerbate bowel dysfunction. High... 

Mineral oil Castor oil Docusate sodium Phenolphthalein Cascara sagrada... 

Oral 5 mg enteric-coated tablets Rectal 5 mg, 10 mg suppositories Cascara sagrada (generic)... 

Cascara Sagrada Rhamnus purshiana) Chamomile Matricaria recutita)... 

Cascara sagrada was used as a laxative in the past and continues to be used for the same purpose today. 

Cascara sagrada [sacred bark], cascara buckthorn)... 

Aloe-emodin, found in cascara sagrada, is being researched as a possible treatment for leukemia. This herb, which has had a place in the U.S. Pharmacopoeia since 1890, is one of the most popular herbal medicines in the world. It is included in many over-the-counter laxatives and is prescribed more than 2.5 million times a year. The bark must be dried for up to 1 year before it can be used officially as a laxative. 

Emodin cathartics Cascara sagrada Senna Rhubarb Aloe... 

Irritant agents used in the treatment of constipation include cascara sagrada, castor oil, senna, rhubarb, phenolphthalein, and acetphenolisatin. Phenolphthalein is a constituent of many over-the-counter preparations, including Corrected , Ex-Lax , and Feen-A-Mint . Most of these agents, with the exception of castor oil, are slow in their onset of action (24 h). 

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