Antihistamines combination products containing

Migraine can often be treated with paracetamol, ibuprofen or aspirin alone, or with combination products containing them. There are also some non-prescription medicines specifically licensed for the treatment of migraine. One such is a coformulation of paracetamol, codeine and the antihistamine buclizine, included for its antiemetic action. Other specific migraine treatments are reviewed below. 

Use of combination oral products containing a decongestant and antihistamine is rational because of the different mechanisms of action. 

Nonnarcotic analgesic combinations usually consist of one or more of the fitUowing agents acetaminophen, salicylates, salsalate, and saUcylamide. Some of the products contain barbiturates, meprobamate, or antihistamines to produce a sedative effect, and antacids may be included to minimize gastric upset associated with the salicylates. Caffeine, a traditional adjuvant in many analgesic combinations, may be beneficial in the treatment of certain vascular headache syndromes. Some belladonna alkaloids may be incorporated for their antispasmodic properties. Pamabrom, a diuretic, and cinnamedrine, a sympathomimetic amine, are sometimes included in products for premenstrual syndrome. 

Antihistamines are found in combination with other ingredients (e.g., decongestants, analgesics) in many over-the-counter cold, sinus, and allergy medications. In addition, liquid products often contain large amounts of alcohol as well. 

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