Colonic cell lines tumor, human

Diallyl sulfide (DAS) Diallyl disulfide (DAOS) Diallyl trisulfide (DATS) inhibition of BP-induced fore-stomach, lung and liver cancer in mice, increase hepatic and fore-stomach GST and EROO activities, inhibition of tumors in human colon cell line (DADS only), anti-mutagenic, antihepatotoxic. 102,105, 107-111. 

Low levels (0.1-1 pg/mL) of resveratrol have been reported to enhance cell proliferation, whereas higher amounts (10-100 pg/mL) cause apoptosis in a vari-ety of tumor and endothelial cells, including JB6 epidermal cells, human promyeloctye leukemia HL-60 cells, THP-1 human monocytic leukemia cells, U937 human promonocytic cells, various colon cancer cell lines, human mammary cancer cell lines, and human prostate cancer cells [121-131]. In somewhat of a contrast to these studies, a very recent report indicated that resveratrol reduced paclitaxel-induced apoptosis in a human neuroblastoma cell line (SH-SY5Y) by blocking paclitaxel-induced phosphorylation of JNKs, Raf-1, and BcT2 [132]. Of particular interest is a recent study in which it was shown to induce apoptosis in leukemic human lymphocytes but, under similar conditions, had no effect on the survival... 

Kalkitoxin showed potent cytotoxicity against the human colon cell line HCT-116 (IC50 1.0 ng/mL) [7]. In a zone differential cytotoxicity assay, kalkitoxin showed differential cytotoxicity for a solid tumor cell (Colon 38) versus... 

Draesne N, Pagniez A, Mayeur C, Thomas M, Cherbuy C, Duee PH, Martel P, Chaumontet C. (2004) Dially disulfide (DADS) increase histone acetylation and p21/wafl/cipl expression in human colon tumor cell lines. Carcinogenesis 25 1227-1236. 

Recently, the piperazine intermediate 15 for the total synthesis of (—)-lemon-omycin (9) was reported by Fukuyama et al. [14], (—)-Lemonomycin possesses interesting antibiotic activity against methiciUin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium, as well as cytotoxicity against the human colon tumor cell line HCT-116 [15]. The reaction of 2-isocyanoethyl phenyl carbonate 11 gave Ugi product 14, which was further transformed to a piperazine intermediate 15 (Scheme 2). 

Phan SC, Morotomi M, Guillem JG, LoGerfo P, Weinstein IB (1991) Decreased levels of 1,2-sn-diacylglycerol in human colon tumors. Cancer Res 51 1571-1573 Piovesan B, Pennell N, Berinstein NL (1998) Human lymphoblastoid cell lines expressing mutant p53 exhibit decreased sensitivity to cisplatin-induced cytotoxicity. Oncogene 17 2339-2350... 

Current efforts favor tumor cell line tests, conducted by the National Cancer Institute (NCI) drug development program [62]. In the current NCI anticancer screen, each compound is tested against 60 human tumor cell lines derived from several cancer types (lung, colon, melanoma, kidney, breast, ovary, brain, leukemia). The tumor cells are seeded on 96-well microtiter plates and pre-incubated for 24 h. The test agents are then added to the wells (five 10-fold dilutions 0.01 -100 pmol/1) and are incubated for 48 h with the tumor cell lines. At the termination of the assay, the cells are fixed in situ with trichloroacetic acid (TCA), washed and dried. Sulforhodamine B (SRB), a dye that binds to the basic amino... 

Recently, Barrero et al. [20] have tested the activity of natural podolactones LL-Z1271a (63) and 68, and of synthetic derivatives 94-99, the latter being a mixture of isomers, against four tumoral cell lines P-388, A-549 (human lung carcinome), HT-29 (human colon carcinome) and MEL-28 (human melanome) (Table 2). The two natural compounds, as well as 98 showed a potent activity (ICso[Pg.470]

Astragaloside II, a cycloartane triterpene glycoside isolated from the Egyptian Astragalus spinosus, was tested at minimum of five concentrations 10-fold dilution against a total of 60 human tumor cell lines derived from seven cancer types (lung, colon, melanoma, renal, ovarian, brain and leukemia). The results indicated that the colon cancer (SW-620) and the leukemias (CCRF-CEM, HL-60) were the most sensitive cell lines [98]... 

Makaluvamine N (65) from the Philippine sponge Zyzzya fuliginosa shows cytotoxicity against the human colon tumor cell line HCT-116 with an LC50 of 0.6 pg/ml [59]. 

The cytotoxicity of makaluvamine F (167), a pyrroloiminoquinone from the Fijian sponge Zyzzya cf. marsailis, against the human colon tumor cell line HCT-116 (IC50 0.17 pM) and Chinese hamster ovary cell line xrs-6 (IC50 0.08 pM) is one to two orders of magnitude higher than the activity of the halogen-free makaluvamines A-E [128]. 

The in vitro anticancer activity of 447 has been studied using a total of 60 human cell lines derived from nine different cancer types (lung, colon, melanoma, prostate, breast, renal, ovarian, CNS, and leukemia). This compound has been tested in a broad concentration range (10 4-10 8M), and it was found that the 1,5,2-dithiazepine 447 is the only compound among its analogues which showed a moderate activity in some tumor cell lines <2001H(55)753>. 

This study describes the effect of sodium butyrate on glyco-lipids from four human colonic tumor cell lines, SKCO-1, HT-29, SW-480 and SW-620 and a human fetal intestinal line, FHS. 

In the present study, we examined the pattern of fucolipids and gangliosides in cultured cell lines and alterations produced by a differentiating agent. A human fetal intestinal line (FHS), and four human colonic tumor lines (SKCO-1, HT-29, SW-480 and SW-620) were used. Cells were grown with or without sodium butyrate, (1.0 mM in SKCO-1 and 2.5 mM in all other cell lines) in... 

---