Lipid glyco-

For the microbial assay, lipids were extracted using a single phase chloroform/methanol/water extraction after Bligh Dyer (1959) as modified by White et al. (1979) to include a phosphate buffer. The total lipid was fractionated into neutral lipid, glyco-lipid and polar lipid fractions by silicic acid column chromatography (SACC) (Parker et al., 1982 White et al., 1983) using the three solvents of increasing polarity (chloroform, acetone and methanol). The polar lipid fraction (PLFA) was... 

AM spores are usually large with significant amounts of reserve in the form of lipids, glyco-... 

EPSs are comprised of repeating units of monosaccharides, which may link with proteins (glycoproteins), lipids (glyco-lipids), acids (e.g., glucuronic acid, galacturonic acid, or mannuronic acid), and/or extracellular DNA. EPSs mosdy... 

An attractive hypothesis is the independent evolution in bacteria of their diffusible individualites and the currently recognized secondary metabolic pathways, in parallel with their surface components and their biosynthesis. An indicator for this would be the use of the same gene pool. The theory would include all substances that play a role in the build-up of glycan and other modified surface layers, lipids, murein, (glyco-) proteins (e.g., S-layers), polysaccharides, teichoic... 

More complex structures, often related to natural products are prepared by organic synthesis. Among them can be mentioned (f )-3-hydroxytetradecanoic acid (the double-tail hydrophobic moiety of lipid A), sphingosine derivatives related to the ceramides or 1,2- and l,3-dialkyl(acyl)glycerols related to glyco-glycerolipids, glycerophospholipids, and GPI anchors of membrane proteins. The preparations of the above derivatives were reported several years ago but some improvements have been published more recently. 

Mechanism of Action An antihyperlipidemic, water-soluble vitamin that is a component of two coenzymes needed for tissue respiration, lipid metabolism, and glyco-genolysis. Inhibits synthesis of VLDLs, Therapeutic Effect Reduces total, LDL, and VLDL cholesterol levels and triglyceride levels increases HDL cholesterol concentration. 

Some compounds known to be inhibitors of peptidoglycan formation in bacteria have proved also to inhibit the lipid pathway of glyco-sylation of proteins. Moreover, these compounds show antiviral activity, because the maturation of enveloped virus in eukaryotic cells is impaired if glyeosylation of viral glycoproteins is inhibited (see Section IV). 

NPC1 257220 NPC1 protein F Complex (glyco-sphingo-)lipid storage disorder ... 

The polysaccharide component of a lipopolysaccharide can be separated from the lipid component by selective hydrolysis of the glyco-sidic linkages of the 3-deoxy-D-manno-octulosonic acid residues connecting these two components. The conditions for the hydrolysis are mild, namely, 0.1 M acetic acid for 1.5 h at 100° (Ref. 18). Similar conditions, namely, M formic acid for 1 h at 100° or 0.05 M hydrogen chloride in methanol for 1 h at 85°, were used to split off the sialic acid residues from gangliosides.19,20... 

Morrison, W. R., Jack, E. L. and Smith, L. M. 1965. Fatty acids of bovine milk glyco-lipids and phospholipids and their specific distribution in the diacylglycerophos-pholipids. J. Am. Oil Chem. Soc. 42, 1142-1147. 

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