Diallyl trisulfide

N.A. Alliin, iodine, diallyl trisulfide, 2-vinyl-4h-l,3-dithin, ajoene, linoleic acid, diallyl disulfide, scordinins, selenium.98 99 107 511 Reduce serum cholesterol, lower blood pressure, and platelet aggregation. It is anticancer, antimicrobial, antithrombotic. 

Another German investigator (Semmler, 1892) also produced garlic oil via steam distillation. The oil yielded diallvl disulfide, CH2=CHCH2SSCH2 CH = CH2, with minor amounts of diallyl trisulfide and diallyl tetrasulfide present. The oil yielded by similar experimentation with onions was different, containing essentially propionaldehyde, C2H5CHO, plus a number of sulfur compounds, of which dipropyl disulfide, C5H12S2, was one. 

Diallyl trisulfide Allium sativum (bulb, garlic oil) (Liliaceae) OD-R (garlic)... 

Diallyl trisulfide (alkene sulfide) Allium cepa (onion), A. sativum (garlic) (Liliaceae) [bulb] SLOX (competitive)... 

Boiled Mainly diallyl trisulfide, diallyl disulfide, allyl methyl trisulfide... 

Garlic contains various sulfur-containing compounds, all of which are derived from allicin, which is formed from alliin by the action of allinase, which is released when garlic is chopped (Srivastava and Tyagi, 1993). Allicin then produces diallyl sulfide, diallyl disulfide, diallyl trisulfide, ajoenes, methyl allyl trisulfides, vinyl dithiins, and other sulfur compounds, depending on how the garlic is prepared. 

Li, N., Guo, R., Li, W., Shao, J., Li, S., Zhao, K., et al. (2005). A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide. Carcinogenesis. 

Aliphatic sulfur derivatives Allium cepa, Allium sativum Allicin, alliin, and diallyl trisulfide [64,67]... 

Boiling of whole cloves inactivates the enzyme allinase and only 0.5-1% of alliin is converted to allicin which is rapidly converted to diallyl trisulfide. Also 12% of the y-glutamylcysteines are hydrolyzed to S-allyl cysteine (SAC) and S-l-propenyl cysteine. A similar loss of alliin is found [37]. Boiling of crushed or tiny chopped garlic enables tiie formation of allicin... 

Among the main garlic-related compounds detected in the breath by GC-AED were allyl methyl sulfide, allyl metfiyl disulfide, diallyl sulfide, diallyl disulfide, 2-propenethiol, dimethyl disulfide, and diallyl trisulfide [54]. Measurements taken shortly after Ae ingestion of garlic and at four hourly intervals thereafter, indicating a more rapid decrease with time of diallyl disulfide than allyl methyl sulfide. Allyl methyl disulfide, diallyl sulfide, and diallyl trisulfide were reported to decrease slowly, while 2-propenethiol vanished rapidly. 

The breath of a test person was analyzed over a time period of about 30 hours by means of proton-transfer-reaction mass spectrometry [55]. After ingestion of cut raw garlic, tiie components allyl metfiyl sulfide, allyl methyl disulfide, diallyl sulfide, diallyl disulfide, diallyl trisulfide, dimethyl sulfide, and acetone were detected. While the concentrations of allyl mediyl disulfide, diallyl sulfide, diallyl disulfide, and diallyl trisulfide reached maximum concentration shortly after ingestion of garlic and declined to baseline values within the next 2-3 h, concentrations of allyl methyl sulfide, dimethyl sulfide, and acetone increased much more slowly... 

Diallyl sulfide (DAS) Diallyl disulfide (DAOS) Diallyl trisulfide (DATS) inhibition of BP-induced fore-stomach, lung and liver cancer in mice, increase hepatic and fore-stomach GST and EROO activities, inhibition of tumors in human colon cell line (DADS only), anti-mutagenic, antihepatotoxic. 102,105, 107-111. 

Steam distillation of garlic produces an oil that also has several different allyl sulfur constituents such garlic oils can contain about diallyl disulfide (DADS, -26%), diallyl trisulfide (DATS, 19%), allyl methyl trisulfide (15%), allyl methyl disulfide (13%), diallyl tetrasulfide (8%), allyl methyl tetrasulfide (6%), dimethyl pentasulfide (4%), dimethyl trisulfide (3%), and dimethyl hexasulfide (1%). The oil derived from macerated garlic contains vinyldithiins and ajoenes. Storage of garlic in ethanol for several months... 

Several of the lipid- and water-soluble organosulfur compounds have been examined for their antiproliferative efficacy [72, 117-128]. Table 4 provides a list of some of the human tumor cells that have been found to be inhibited by garlic and/or its allyl sulfur compounds some of the more commonly used lipid-soluble allyl sulfur compounds in tumorigenesis research are ajoene, diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS). A breakdown of allicin appears to be necessary for achieving maximum tumor inhibition. Studies by Scharfenberg et al. [117] found that the ED50 for lymphoma cells was two times lower for ajoene than for allicin. 

Chan, K.C., M.C. Yin, and W.J. Chao. 2007. Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats. Food Chem. Toxicol. 45(3) 502-507. Cox, M.C., J. Low, J. Lee, et al. 2006. Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel. Clin. Cancer Res. 12(15) 4636-4640. 

Europe 0.03 for the related substance diallyl trisulfide and 10 concern USA ND (No. 587) (Morgareidge Oser, 1970b) is Japan 0.08 >4 million times the estimated daily intake of allyl propyl disulfide when used as a flavouring agent. 

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