Resveratrol reduced

King RE, Kent KD, Bomser JA. 2005 Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 151 143-149. 

Xia, L., Wang, X.X., Hu, X.S., Guo, X.G., Shang, Y.P., Chen, H.J., Zeng, C.L., Zhang, F.R., Chen, J.Z. (2008). Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br. J. Pharmacol. June 30. (Epub ahead of print)... 

Low levels (0.1-1 pg/mL) of resveratrol have been reported to enhance cell proliferation, whereas higher amounts (10-100 pg/mL) cause apoptosis in a vari-ety of tumor and endothelial cells, including JB6 epidermal cells, human promyeloctye leukemia HL-60 cells, THP-1 human monocytic leukemia cells, U937 human promonocytic cells, various colon cancer cell lines, human mammary cancer cell lines, and human prostate cancer cells [121-131]. In somewhat of a contrast to these studies, a very recent report indicated that resveratrol reduced paclitaxel-induced apoptosis in a human neuroblastoma cell line (SH-SY5Y) by blocking paclitaxel-induced phosphorylation of JNKs, Raf-1, and BcT2 [132]. Of particular interest is a recent study in which it was shown to induce apoptosis in leukemic human lymphocytes but, under similar conditions, had no effect on the survival... 

Resveratrol has been reported to inhibit all three stages of carcinogenesis initiation, progression, and promotion in several types of cancer. Several reports suggested that resveratrol inhibits cancer initiation in various model systems. Sharma et al. found that resveratrol reduced 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced free-radical formation in human promyelocytic leukemia cells HL-60. In another model, resveratrol also inhibited 7,12-dimethylbenzfi3)anthracene (DMBA)-induced preneoplastic lesion in... 

Concerning the in vivo effect of resveratrol on tumor growth, it was shown that resveratrol reduced the incidence and number of tumor foci of V-methyk -nitrosourea-induced tumors in rat model. However, using 4T1 breast cancer cells, Bove et al. reported that although resveratrol inhibited cell proliferation in vitro, inhibition of tumor growth was not observed in vivo. 

Increased production of resveratrol Reduced production of biogenic amines... 

When orally administered to a transgenic mouse model (Tg 19959) of Alzheimer s disease at a dosage of 300 mg/kg for 45 days, resveratrol reduces plaque formation mainly in medial cortex (—48%), striatum (—89%), and hypothalamus ( 90%) without alterations in APP processing or SlRT-1 activatirai [84]. 

To test the effect of resveratrol on Alzheimer s disease and tauopathies, the inducible p25 transgenic mouse model [85, 86] was used. For this study, resveratrol was dosed via intra-cerebroventricular injection for 3 weeks, which prevented neurodegeneration in the hippocampus and cognitive decline [87]. Moreover, resveratrol reduced the extent of cell death caused by p25 in transfected primary neurons. SlRT-1 deacetylase was found to be involved in these resveratrol s neuroprotective effects in both the in vitro and in vivo studies. 

Karuppagounder SS, Pinto JT, Xu H, Chen H-L, Beal MF, Gibson GE (2009) Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer s disease. Neurochem Int 54 111-118... 

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