Colon-38 tumor cells

Da Violante, G., Zerrouk, N., Richard, I., Provot, G., Chaumeil, J.C., and Arnaud, P., Evaluation of the cytotoxicity effect of dimethylsulfoxide (DMSO) on Caco2/TC7 colon tumor cell cultures, Biol. Pharm. Bull., 25,1600, 2002. 

Draesne N, Pagniez A, Mayeur C, Thomas M, Cherbuy C, Duee PH, Martel P, Chaumontet C. (2004) Dially disulfide (DADS) increase histone acetylation and p21/wafl/cipl expression in human colon tumor cell lines. Carcinogenesis 25 1227-1236. 

Recently, the piperazine intermediate 15 for the total synthesis of (—)-lemon-omycin (9) was reported by Fukuyama et al. [14], (—)-Lemonomycin possesses interesting antibiotic activity against methiciUin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium, as well as cytotoxicity against the human colon tumor cell line HCT-116 [15]. The reaction of 2-isocyanoethyl phenyl carbonate 11 gave Ugi product 14, which was further transformed to a piperazine intermediate 15 (Scheme 2). 

The increased expression of adhesion molecules by the endothelium may activate polymorphonuclear neutrophils (PMN) in rabbits [72], During endotoxic shock, activated PMNs release their granule content and secrete both proinflammatory and cytotoxic molecules. Pickaver et al. [73] were the first to show PMN cytotoxicity against tumor cells. We showed that PMNs are toxic for PROb colon tumor cells [74] in BDEX rats. In vivo, PMNs have been implicated in the Schwartzman reaction [75], and may be involved in LPS-induced tumor necrosis. PMNs, when activated by LPS, synthesize and release NO. The role of NO in tumor growth will be discussed later. The decrease in tumor growth after intradermal injections of LPS is attributed to the induction of TNF-a secretion by PMNs both in intradermal tumors (Meth A sarcoma in BALB/c mice, MH-134 hepatoma in C3H/He mice, Lewis Lung carcinomas in C57BL/6 mice) and pulmonary Meth A metastases [76,77],... 

Newaz, S.N., Fang, W.-F. Strobel, H.W. (1983) Metabolism of the carcinogen 1,2-dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture. Cancer, 52, 794-798... 

Makaluvamine N (65) from the Philippine sponge Zyzzya fuliginosa shows cytotoxicity against the human colon tumor cell line HCT-116 with an LC50 of 0.6 pg/ml [59]. 

The cytotoxicity of makaluvamine F (167), a pyrroloiminoquinone from the Fijian sponge Zyzzya cf. marsailis, against the human colon tumor cell line HCT-116 (IC50 0.17 pM) and Chinese hamster ovary cell line xrs-6 (IC50 0.08 pM) is one to two orders of magnitude higher than the activity of the halogen-free makaluvamines A-E [128]. 

Mahyar-Roemer M, Katsen A, Mestres P, Roemer K. 2001. Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse. Int J Cancer 94 615-622. 

This study describes the effect of sodium butyrate on glyco-lipids from four human colonic tumor cell lines, SKCO-1, HT-29, SW-480 and SW-620 and a human fetal intestinal line, FHS. 

Another cyclic peptide, halobacillin, was isolated from a marine-derived Bacillus sp. isolated from a deep-sea sediment core.31 Halobacillin (Structure 18.21) was only produced in sea-water-based media and is similar in structure to the surfactins and iturins. Interestingly, the compound exhibits cytotoxicity against the human colon tumor cell fine HCT-116 but lacks the antibacterial activity associated with surfactin. 

Does the active form of the Bowman-Birk inhibitor reach the colon If so, what is the effect on colon tumor cells ... 

Zweibaum A, Traidou N, Kedinger M et al. (1983) Sucrase-isomaltase a marker of foetal and malignant epithelial cells of the human colon. Int J Cancer 32 407 112 Zweibaum A, Pinto M, Chevalier G et al. (1985) Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose. J Cell Physiol 122 21-29... 

Cyclodidemnamides 401 and 402, isolated from the sea squirt D. molle, having a rare substitution pattern of an alternating sequence of thiazole, oxazoline, thiazoline, and pyrrolidine rings, are weak inhibitors of human colon tumor cell growth <1995TL8355, 1998TL3087>. 

Three new cytotoxic cyclopeptides, mixirins A 85, B 86, and C 87, of iturin class were isolated from marine bacterium Bacillus sp. These three compounds inhibited the growth of human colon tumor cells (HCT-116) with IC50 of 0.68, 1.6, 1.3 pg mL respectively. Solid-phase synthesis of the mixirins were also reported. ... 

Mirixins A, B, and C (Fig. 57) were isolated from an ethyl acetate extract of marine bacterium Bacillus sp., obtained from sea mud near the Arctic pole by Zhang et al. in 2004. Mirixins contain three asparagine residues and the P-amino fatty acyl side chains. Mirixins A, B and C exhibit growth inhibition with IC50 values of 0.68, 1.6 and 1.3p.g/ml, respectively against HCT-116 human colon tumor cells ... 

Fig. 1. A typical dose response curve obtained by clonogenic assay. The human colon tumor cell line HT29 in exponential growth was exposed to mitomycin C for 3 h and then plated out at a density of 500 cells/6 cm Petri dish. The mean colony count in the control dishes was 281, which is a cloning efficiency of 56%. Three flasks of cells were used at each dose level and each point is the mean standard error of the mean of the three estimates. Estimation of the IC50 value (the drug concentration required to kill 50% of the cells) is shown by the straight lines.

Koi, M., Umar, A., Chauhan, D. P., Cherian, S. P., and Carethers, J. M., (1994) Human chromosome 3 corrects mismatch repair deficiency and reduces N-methyl-N -nitro-iV-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLHl mutation. Cancer Res. 54,4308 4312. 

Rhus pyroides Bureh. (syn. Rhus tridentata) (root bark) Bichalcones. Rhusehalcone I (294) rhusehaleone II (295) rhusehaleone III (296) rhusehaleone IV (297) rhusehaleone V (298) rhusehaleone VI (292). Insect antifeedant, cytotoxic and antiproliferative activities. All bichalcones exhibited seleetive cytotoxic activity against the HT29 and HCT-116 colon tumor cell lines. Abegaz, 2002[133] Mdee et ah, 2003[134]. 

Makaluvamines (pyrroloiminoquinones) 51 (Fig. 4) isolated from a Fijian sponge in the early 1990s display in vitro cytotoxicity against human colon tumor cell Unes and also inhibit human topoisomerase II in vitro. The benzimidazole analog of this indole-based marine natural product, imidazo-quinoxaUnone 52, has been synthesized starting fromp-methoxydiacetanilide (Scheme 12) [51]. Treatment of the dinitration product 54 of p-methoxy-... 

H9. Hoosein, N. M., Kiener, P. A., Curry, R. L., and Brattain, M. G., Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide. Exp. Cell Res. 186, 15-21 (1990). 

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