Chemically induced preventing

Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Liebcrman, A. I. and Shmidt, J. L., Prevention of spontaneous and chemically-induced carcinogenesis using activated carbon fiber adsorbent. I. Effect of the activated carbon fiber adsorbent Aqualen on spontaneous carcinogenesis and life span in mice, Cancer Lett., 1998, 126(1), 23 28. 

Bondy SC, McKee M, Davoodbhoy YM. 1990a. Prevention of chemically induced changes in synaptosomal membrane order by ganglioside GMI and alpha-tocopherol. Biochim Biophys Acta... 

The data in this paper are consistent with a wealth of evidence showing that dietary Se consumed in excess of the Recommended Dietary Allowance lowers the risk of several important cancers (2, 14, 26, 27). Previous research has established a strong association between the dietary form of Se and the cancer-preventive properties of this element (5, 28). This paper extends the evidence that Se in chemical forms known to accumulate in garlic and some Brassica species is especially effective in the prevention of chemically induced carcinogenesis (14, 17). 

Because induction of DMEs can enhance clearance of xenobiotic chemicals, specific agents are being tested for potential prevention of chemically induced toxicity, especially for chemoprevention of cancer. Oltipraz, originally developed as an anti-schistosomal drug, induces multiple Phase... 

Contraindications None noted. Acts as a systemic hemostatic preventing capillary bleeding during injury. Adrenochrome causes chemically induced schizophrenia. Its semicarbazone does not. Supplier CS. 

Additionally there has been an increasing interest in the role of vitamins, especially the antioxidant vitamins, vitamins C and E, and the carotenoids in protection from ultraviolet (UV)- or chemically-induced oxidative stress as well as in the prevention and treatment of photoaged skin. UVB radiation (280 to 320 nm) is mostly absorbed in the epidermis, can directly damage DNA, and... 

A number of animal studies have shown that dietary fibers, which liberate a constant and elevated supply of butyrate to the colon, are the most effective for prevention of chemically induced colon tumors. Moreover, the level of butyric acid in the colonic lumen of patients with colorectal cancer and adenomas was found to be lower than that in healthy individuals (Parodi, 2004). 

Both p-carotene and vitamin A can inhibit growth in a large range of human cancer cell lines (Krinsky, 1993 Niles, 2000). Several animal studies have shown that vitamin A deficiency promotes the development of spontaneous and chemically-induced tumors, whereas dietary supplementation with vitamin A can prevent chemically-induced tumor development (Niles, 2000). Likewise, p-carotene protects against tumor development in animal models (Krinsky, 1993 Cooper, 2004 Russell, 2004). Nevertheless, P-carotene is preferred for human studies because blood and tissue levels increase in proportion to dietary intake, whereas vitamin A level does not increase in a linear manner because of homeostatic regulation high levels of vitamin A are toxic (Cooper, 2004). 

The hallmark of the anticarcinogenic effect of DR is the ability of diet restriction to prevent chemical-induced tumors. The first reports of inhibition of chemical carcinogenesis came in the 1940s. 

The continuing worldwide increase in respiratory disease corresponds to increases in the release of chemicals into the atmosphere. Respiratory irritation, sensitization, asthma, RADS, and lung cancer can be attributed to numerous single chemicals whose toxicological properties are, for the most part, well known. Many unexplained incidences of respiratory disease cannot be attributed to single chemical exposures, but have been shown to occur when exposures are to chemical mixtures that are composed of at least one lipophile and one hydrophile. The sources of such mixtures include diesel exhausts, tobacco smoke, carpet emissions, paint fumes, and cleaning products. Prevention of chemically induced respiratory diseases should include limiting exposures to these chemical mixtures. 

The occurrence of heat- and chemical-induced transformations of tryptophan and the nutritional and toxicologic consequences suggest a need for additional research to define possible approaches to prevent or minimize the formation of antinutritional and toxic tryptophan condensation and oxidation products in foods. The possible beneficial effects of antioxidants such as vitamins C and E, carotenes, flavonoids, indole derivatives, selenium compounds, and sulfur amino acids in enhancing the stability of tryptophan in foods need to be investigated. 

The use of selective ERa modulators has provided information similar to that obtained from ERKO transgenic mice. PPT stimulated uterine proliferation as well as ethinyl-estradiol, prevented bone mineral density loss in ovariectomized rats, lowered serum cholesterol levels and prevented hot flashes in a chemically induced hot flash rat model [17]. The use of PPTalso showed that ERa is primarily responsible for the effects of estrogen on the pituitary, vasodilation, neuroprotection, cardioprotec-tion and insulin sensitivity (reviewed in Ref. [18]). Protective effects were also... 

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