17-ethinyl estradiol

Molecular formula C2oHa40a Molecular weight 296.4 CAS Registry No. 57-63-6 [Pg.579]

Sample preparation 1 mL Plasma -I- 500 xL 10 M NaOH, shake on a slow rotatory mixer for 5 min, add 5 mL diethyl ether, rotomix 10 min, centrifuge at 700 g for 5 min, repeat extraction. Combine organic layers, evaporate to dryness under a stream of nitrogen at 37°, dissolve in 250 pL mobile phase, inject aliquot. [Pg.579]

Mobile phase MeCN MeOH buffer 35 15 50 (Buffer was 50 mM KH2PO4 adjusted to pH [Pg.579]

Detector E, Waters Model 464 pulsed electrochemical detector, -I- 1 V versus Ag/AgCl [Pg.579]

Simultaneous estradiol, estriol, estrone, heparin Noninterfering pentobarbital [Pg.579]

Fernandez, N. Garcia, J.J. Diez, M.J. Teran, M.T. Sierra, M. Rapid hi -performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma. J.Chromatogr., 1993, 619, 143—147 [Pg.579]

The two synthetic steroidal estrogens which have attained the greatest degree of therapeutic use are ethinyl estradiol [57-63-6] (EE) (5) and its 3-methyl ether, mestranol [72-33-3]((5). In contrast to the naturally occurring estrone derivatives, these acetylenic analogues are orally active and are the main estrogenic components of combination oral contraceptives (see Contraceptives) and certain estrogen replacement products. [Pg.231]

Ethinyl estradiol-norethindrone unless otherwise noted. [Pg.112]

Trade name Ethinyl estradiol Regimen, days Dosage, Hg Progestogen Regimen, days a Dosage, mg Launch date Manufacturer... [Pg.113]

SIMULTANEOUS DETERMINATION OF LEVONORGESTREL AND ETHINYL ESTRADIOL IN LOW-DOSE ORAL CONTRACEPTIVES BY HPTLC-DENSITOMETRY... [Pg.358]

A major obstacle to the use of naturally occurring estrogens for the purpose of contraception was extensive first-pass hepatic metabolism and hence inactivation of the compounds when given orally. The addition of an ethinyl group at the 17 position made estradiol orally active. Ethinyl estradiol is a potent oral estrogen and... [Pg.389]

In epidemiologic studies, all products containing less than 50 pg ethinyl estradiol per pill are summarized as low-dose oral contraceptives. The first generation of oral contraceptives includes products with 50 pg... [Pg.390]

Taking the contraceptive hormones provides health benefits not related to contraception, such as regulating the menstrual cycle and decreased blood loss, and incidence of iron deficiency anemia, and dysmenorrhea Health benefits related to the inhibition of ovulation include a decrease in ovarian cysts and ectopic pregnancies. hi addition, there is a decrease in fibrocyctic breast disease, acute pelvic inflammatory disease endometrial cancer, ovarian cancer, maintenance of bone density, and symptoms related to endometriosis in women taking contraceptive hormones. Newer combination contraceptives such as norgestimate and ethinyl estradiol... [Pg.547]

MonophasicOral Contraceptives 50 meg ethinyl estradiol acetate img norethindrone 50 meg ethinyl estradiol, 1 mg ethynodiol diacetate 50 meg ethinyl estradiol, 0.5 mg norgestrel 35 mg ethinyl estradiol, 1 mg norethindrone 35 meg ethinyl estradiol, 0.5 mg norethindrone 35 meg ethinyl estradiol, 0.4 mg norethindrone 35 meg ethinyl estradiol, 0.25 mg norgestimate 35 meg ethinyl estradiol, 1 mg ethynodiol diacetate... [Pg.548]

Fhase one 35 meg ethinyl estradiol, 0.5 mg norethindrone Fhase two 35 meg ethinyl estradiol, 1 mg norethindrone Triphasic Oral Contraceptives... [Pg.548]

Activella—estradiol, norethindrone acetate CombiFhtch—estradiol, norethindrone Femhrt—ethinyl estradiol, norethindrone acetate Ortho-Pretest—estradiol, norgestimate Premephase—conjugated estrogens, medroxyprogesterone acetate... [Pg.682]

Miranova (Schering)-comb. Prosiston (Schering)-comb. Ethinyl-Estradiol Roussel... [Pg.798]

Desogen (Organon) Estrostep (Parke Davis) Ethynodiol Diacetate and Ethinyl Estradiol (Watson) Levlen (Berlex)... [Pg.799]

Nelova (Warner Chilcott) Nordette (Wyeth-Ayerst) Norethin (Roberts) Norethindrone and Ethinyl Estradiol (Watson)... [Pg.799]

Cyproterone acetate (CPA) is a progestational antiandrogen that blocks the androgen receptors. It is combined with ethinyl estradiol in an oral contraceptive formulation, which is indicated in female acne patients with a high level of seborrhea, therapy resistant papulo-pustular acne or acne conglobata not responding to other treatments. [Pg.131]

Maggs, J.L., Grabowski, P.S., and Park, B.K. (1983). Drug protein conjugates. 2. An investigation of the irreversible binding and metabolism of 17-alpha-ethinyl estradiol in vivo. Biochemical Pharmacology 32, 301-308. [Pg.359]

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