Anticarcinogenic effects

Much less is known about the cytotoxic and antiproliferative effects of the 20(S)-PPT family of ginsenosides. Ginsenoside Rhi has been reported to inhibit proliferation of the NIH 3T3 mouse fibroblast cell line but did 

Finally, it has been shown that maturation of DCs is promoted by metabolized ginsenosides such as compound K. Takei et al (2004) showed that mature DCs differentiated with compound K enhance the differentiation of naive T cells toward the Thl t) e depending on lL-12 secretion, which clearly suggests that compound K has immunostimulatoty effects and that this compound is involved in the cancer preventive effects of ginseng and that compound K may be used on DC-based vaccines for cancer immunotherapy (Takei et al, 2004). 

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Not only is TCDO a potent therapeutic agent in acute radiation syndrome, but treatment using TCDO from days 4—11 after TBI increases the survival rate in rats for up to one year, protects against the development of late GI ulcers, and also reduces the development of y-ray-induced leukemias and malignant epitheHal tumors, but not sarcomas (202). The anticarcinogenic effect of TCDO maybe related to the inhibition of PGs, which promote carcinogenesis, or to immunostimulation, which may result in a more effective elimination of malignant cells. 

JOHNSON, I T (2001) Mechanisms and possible anticarcinogenic effects of diet related apoptosis in colorectal mucosa . Nutrition Research Reviews, 14 229-56. 

FUJIKI H, YOSHIZAWA S, HORIUCHI T, SUGANUMA M, YATSUNAMI J, NISHIWAKI S, OKABE S, NISHIWAKI-MATSUSHIMA R, OKUDA T and suGiMURA T (1992) Anticarcinogenic effects of (-)-epigallo-catechin gallate , Prev Med, 21, 503-9. 

Johnson I T (2002), Anticarcinogenic effects of diet-related apoptosis in the colorectal mucosa , Food Chem Toxicol, 40, 1171-1178. 

Ozukul, Y., Silici, S. and Eroglu, E. (2005) Phytomedicine, The anticarcinogenic effect of propolis in human lymphocytes culture, 12, 742-747. 

Aruna, K., and V. M. Sivaramakrish-nan. Anticarcinogenic effect of some Indian plant products. Food Chem Toxicol 1992 30(11) 953-956. 

A possible mechanism for the potential anticarcinogenic effects of flavonoids could be their ability to inhibit various PKs (demonstrated with purified enzymes or cell extracts). For... 

Zi, X.L. et al., A flavonoid antioxidant, silymarin, inhibits activation of erbBl signaling and induces cyclin-dependent kinase inhibitors, G1 arrest and anticarcinogenic effects in human prostate carcinoma DU145 cells, Cancer Res., 58, 1920, 1998. 

Friedman, M., Lee, K. R., Kim, H. J., Lee, 1. S., Kozukue, N. (2005). Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma, and stomach cancer cells. J. Agric. Food Chem., 53, 6162-6169. 

Recently, Germain et al. (90) studied the in vivo metabolism of diallyl disulfide (DADS), a garlic compound claimed to have anticarcinogenic effects. After oral administration of a single dose of 200mg/kg, metabolites were measured in the stomach, liver, plasma, and urine by GC coupled with MS over 15 days. DADS was detected in almost all analyzed tissues within the first hours. In addition, the metabolites allylmercaptan (AM) and allyl methyl sulfide (AMS) were detected. The Cmav of the metabolites were higher than that of DADS (1.46 pg/mL). The %ax for DADS was estimated to be less than one hour, whereas this time increased to 24 hours for AM and AMS (90). 

Astragalus chinensis L. Sha Yuan Zi (Vetch) (seed) Astragalin, canavanine, homoserine.33 436 Sedative, antibacterial, antiviral, anticarcinogenic effect. 

Berry DL, Slaga TJ, DiGiovarmi J, et al. 1979. Studies with chlorinated dibenzo-(p)-dioxins, polybrominated biphenyls, and polychlorinated biphenyls in a two-stage system of mouse skin tumorigenesis Potent anticarcinogenic effects. Ann N Y Acad Sci 320 405-414. 

This chapter discusses the anticarcinogenic effects of green tea catechins, especially EGCG in different organ sites and effects on cellular signaling events. 

ANTICARCINOGENIC EFFECTS OF GREEN TEA POLYPHENOLS Green Tea Polyphenols and Lung Cancer... 

Direct proof regarding whether antimutagenic or anticarcinogenic effects also occur in humans under normal dietary conditions can only be obtained from studies with humans. Indeed, epidemiological studies indicate that consumption of fruits and vegetables is inversely associated with the risk of cancer. In particular, brassica vegetables such as cabbage, brussels sprouts, and broccoli have been attributed with beneficial health effects in humans. 

Cohen GM, Bracken WM, Iyer RP, et al. 1979. Anticarcinogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene tumor initiation and its relationship to DNA binding. Cancer Res 39 4027-4033. 

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