CD8+T cell

CD8+ T-cells + + + TNF, perforins, granzymes, activation of Fas-dependent apoptosis... 

Although a humoral immune response is the primaiy protection against most viral and some bacterial diseases, protective defense against other pathogens such as HIV, Plasmodium and Mycobacterium tuberculosis requires a cytotoxic response mediated by CD8+ T-cells (CTL response). Since the introduction of the vaccination concept by Jenner almost 200 yeats ago, only few vaccines have been developed that are able to induce a CTL response. These vaccines are usually attenuated live vaccines that are accompanied by certain risks and are not readily available for most pathogens. The immense appeal of DNA vaccines can be attributed to a considerable part to the fact that they are able to induce... 

Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW, Van Baade D, Kostense S, Miedema F, McLaughlin M, Ehler L, Metcalf J, Liu S, Connors M (2002) HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in non-progressors, Nat Immunol 3 1061-1068... 

Wells JW Cowled CJ, Giorgini A. Kemeny DM. Noble A Regulation of allergic airway inflammation by class I-restricted allergen presentation and CD8 T-cell infiltration. J Allergy Clin Immunol 2007 119 226-234. 

Decreased macrophage infiltration and demyelination Decreased CD4+ T cell trafficking into the CNS, impaired viral clearance No effect on CD8+ T cell trafficking into the CNS Enhanced fatality with delayed CD 8+ T cell infiltration No effect CCR5A32 not protective... 

Transection or severing of the axon disrupts nerve signals completely and irreversibly.8 There is growing evidence that cytotoxic (CD8+) T cells cause axonal injury.5 Axonal transection begins as early as 2 weeks after diagnosis and continues throughout the course of the disease.9... 

Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995 270 1811-1815. 

Yang YF, Tomura M, Iwasaki M, et al. IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells. J Clin Immunol 2001 21 116-125. 

Carramolino L, Zaballos A, Kremer L, et al. Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8(+) T cells from secondary lymphoid organs. Blood 2001 97(4) 850-857. 

Bradfield PF, Amft N, Vemon-Wilson E, et al. Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue. Arthritis Rheum 2003 48(9) 2472-2482. 

Schaller MA, Lundy SK, Huffnagle GB, Lukacs NW. CD8+ T cell contributions to allergen induced pulmonary inflammation and airway hyperreactivity. Eur J Immunol 2005 35(7) 2061-2070. 

Harouse JM, Buckner C, Gettie A, et al. CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques. Proc Natl Acad Sci U S A 2003 100(19) 10977-10982. 

Lacey SF, McDanal CB, Horuk R, Greenberg ML. The CXC chemokine stromal cell-derived factor 1 is not responsible for CD8+ T cell suppression of syncytia-inducing strains of HIV-1. Proc Natl Acad Sci U S A 1997 94(18) 9842-9847. 

Breen, E., etal. (1997). Circulating CD8 T cells show increased interferon-y mRNA expression in HIV Infection. Cell. Immunol. 178,91-98. 

Koyama, K., Tamanchi, H. and Ito, Y. (1995) The role of CD4+ and CD8+ T cells in protective immunity to the murine parasite Trichuris muris. Parasite Immunology 17, 161-165. 

Urban, J.F., Katona, I.M. and Finkelman, F.D. (1991a) Heligmosomoides polygyrus CD4+ cells but not CD8+ T cells regulate the IgE response and protective immunity in mice. Experimental Parasitology 73, 500-511. 

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