Lymphomas carcinomas

CCI-779 - renal carcinoma, lymphoma AP23573 - sarcomas RAD-001 - pancreatic cancer Again, several preclinical studies suggest that rapalogs will have synergistic affects when used in combination with other chemotherapeutics. 

VIP receptors Colonic carcinomas, gastrin carcinomas, pancreatic carcinomas, lymphomas... 

Hormone-sensitive tumors may regress, and frequently stop growth upon introduction of certain hormones. The main hormone-sensitive forms of cancer are breast and prostate carcinoma, lymphoma, and a few other forms of carcinomas. 

Pancreatic carcinoma Lymphoma, bronchogenic carcinoma Infectious diseases AIDS... 

Figure 7.11 Examples of topoisomerase inhibitors. Ellipticene acts by both intercalation and inhibition of topoisomerase II enzymes. It is active against nasopharyngeal carcinomas. Amsacrine is used to treat ovarian carcinomas, lymphomas and myelogenous leukaemias. Camptothecin is an antitumour agent...

Trade names Cisplatyl Plasticin Platiblastin Platinex Platinol (Bristol-Myers Squibb) Platinol-AQ Platistil Indications Carcinomas, lymphomas Category Alkylating agent Antineoplastic Half-life a phase 25-49 minutes (3 phase 58-73 hours Clinically important, potentially hazardous interactions with aldesleukin, atenolol, chlorothiazide, methotrexate, selenium, torsemide, zinc... 

Chronic inflammatory liver diseases Malignancies Carcinoma Lymphoma Leukemia Multiple myeloma Less common causes Alcoholic liver disease Congestive heart failure Thrombophlebitis Chronic obstructive lung disease Ischemic heart disease... 

Folpe and associates were the first to study FEI-1 immu-noreactivity in human endothelial neoplasms.They observed a 94% marker sensitivity in that specific context and found no labeling of nonvascular tumors. However, more recently, Mhawech-Fauceglia and colleagues have documented FLI-1 positivity in some carcinomas, lymphomas, and rhabdomyosarcomas as well. In aggregate, these data support the use of FLI-1 as an adjuvant to the diagnoses of PNET or vascular neoplasms, but only in combination with other immunoreactants. 

ISH EBV Nasopharyngeal carcinomas, lymphomas (Burkitt, Hodgkin, some T-cell lymphomas), subset of gastric cancers, immunodeficiency associated tumors... 

Ic-Mab BW 250/183 Scintimum Granulo/.yt Rchiing 27 (1000) Mammary and prostatic carcinoma, lymphoma, small cell lung cancer... 

Metal-based drugs have probably had most impact in the area of cancer therapy, with cisplatin still used to treat approximately 70% of all cancer patients. Cisplatin is particularly useful for treatment of testicular, ovarian, oropharyngeal, bronchogenic, cervical, and bladder carcinomas, lymphoma, osteosarcoma, melanoma, and neuroblastoma. Metallocene-type compounds were the first organometallic compounds to be evaluated in cancer therapy, and until recently, Ti(77 -C5H5)2Cl2 was undergoing clinical trials (see above). Despite this setback to the field,... 

Neovascularisation/extramucosal hyperaemia Benign tumor (leiomyoma etc.) Malignant tumor (carcinoma, lymphoma etc.) Metastatic tumor (renal cell cancer etc.)... 

Bleomycins glycopeptide antibiotics produced by Streptomyces verticillus and used widely for treatment of squamous cell carcinomas, lymphomas and testicular cancer. About 200 different B. are known, differing mostly in the nature of the C-terminal substituent, which can be varied by adding difierent amines to the bacterial culture medium. The clinically used preparation is a mixture of 11 B., known by the trade name Blenoxane the chief constituents are B.A2 (60-70%) and B.B (20-25%) (Fig.). 

Clinically the lesion appears with diffuse penile swelling or like a mass, a plaque or an ulcer in the penile skin. Contrary to squamous cell carcinoma, lymphoma usually presents in the penile shaft rather than in the glans and prepuce. At color Doppler ultrasonography penile lymphoma presents as an isoechoic or relatively hypoechoic hypervascu-larized lesion (Fig. 14.5). Infiltration of the corpora cavernosa is often present. 

All organs Colon Kidney Epithelial carcinomas Lymphomas, melanomas... 

These include carcinomas, lymphomas, GISTs, and secondary deposits. Adenocarcinoma accounts for approximately 75% of malignant tumours, lymphomas some 20%, and the rest the remaining 5%. 

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