Testicular cancers

The incidence of testicular cancer rose sharply in the twentieth century. I48 Because testicular cancer occurs predominantly in younger men (aged 15-19), this increase has contributed to overall male infertility. The steep increase in testicular cancer has been associated with in utero exposures to endocrine disruptorsJ56,57  

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Eadier reports of a link between testicular cancer and DMF exposure have not been corroborated ia a study of 4000 Du Pont employees (34). Very recendy, inhalation studies ia mice and rats have shown no oncogenic effect from DMF (35). The International Agency for Research on Cancer (lARC) has concluded that evidence associating DMF with cancer ia animals is "iaadequate," but has classified DMF as "possibly carciaogenic to humans" (Group 2B) (36). 

However, incidence of testicular cancer is increasing in American blacks and Japansese, both of whom have a low incidence of testis cancer. " Extrapolation of the epidemiological trends suggests that the incidence rate of testis cancer will continue to double every 15-25 years. 

It is widely accepted that men with testicular cancer have a higher incidence of abnormalities associated with impaired spermatogenesis, both in the cancerous testis but also in the contralateral testis. Men diagnosed as having testicular cancer often have very poor semen quality, with sperm concentrations of less than 10 million/ml compared to healthy men with > 50 million/ml." It is thought that gonadal function is abnormal even before testicular cancer develops, ... 

In order to discuss the biological mechanisms involved in the aetiology of genital tract malformations, testicular cancer and lowered sperm counts, some knowledge of the processes involved in the differentiation and development of the male reproductive tract and determination of normal testicular function is required. An early embryo has the potential to develop either a male or a female... 

Abnormal Germ Cell Development and Testicular Cancer... 

Hodgkin s disease, lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, testicular cancer, Kaposi s sarcoma, breast cancer Acute leukemia, combination therapy for various cancers... 

Testicular cancer SCLC NSCLC ANLL KS HD NHL BMT preparative chemotherapy gastric cancer... 

Breast cancer Small cell lung cancer Testicular cancer Patient Related... 

Schwartz G G (2002), Hypothesis does ochratoxin A cause testicular cancer Cancer Causes and Control. 13, 91-100. 

Causes of organic ED include diseases that compromise vascular flow to the corpora cavernosum (e.g., peripheral vascular disease, arteriosclerosis, essential hypertension), impair nerve conduction to the brain (e.g., spinal cord injury, stroke), and are associated with hypogonadism (e.g., prostate or testicular cancer, hypothalamic or pituitary disorders). 

Bleomycin (BLM) was first isolated as a copper complex from a culture of Streptomyces verticillus. Since then numerous analogs have been prepared by modifying the conditions of fermentation. Bleomycins (114, bleomycin A2) are used clinically in combination cancer chemotherapy for the treatment of head and neck cancer, certain lymphomas, and testicular cancer (555). 

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