Caffeic phenethyl ester

Yilmaz HR, Uz E, Yucel N, Altuntas I, OzceUk N. (2004) Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat Uver. J Biochem Mol Toxicol 18 234-238. 

Chemical structures of reported inhibitors of HIV-1 integrase. (I) aurintricarboxylic acid monomer (II) cosalane (III) dihydronaphthoquinone or DHNQ (IV) primaquine (V) caffeic acid phenethyl ester or CAPE (VI) quercetin (VII) quercetagetin (VIII) AG1717 (IX) 3-conidendrol (X) suramin (XI) curcumin. 

Caffeic acid phenethyl ester Populus sp. (Salicaceae), bee propolis (phenvlpropanoid)... 

Minsavage, G.D., Dillman lii, J.F. (2007). Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor-kappa B (NF-ICB) responses and cell death are altered by caffeic acid phenethyl ester (CAPE) a potential role for antioxidant/elec-trophilic response element (ARE/EpRE) signaling. J. Pharmacol. Exp. Ther. 321 202-12. 

Interventions to ameliorate the nephrotoxicity observed with vancomycin have largely been confined to the laboratory and have focused on attenuating oxidative stress. Oxidative stress has been postulated as the primary mechanism in the pathogenesis of vancomycin-induced nephrotoxicity [200]. A study by Ocak et al tested a diverse group of antioxidants that included caffeic acid phenethyl ester (CAPE), vitamin C, vitamin E and N-acetylcysteine [198]. Each of these agents were... 

Ocak S, Gorur S, Flakverdi S, Celik S, Erdogan 5, Protective effects of caffeic acid phenethyl ester, vitamin C, vitamin E and N-ace-tylcysteine on vancomycin- induced nephrotoxicity in rats, Basic Clin Pharmacol Toxicol, 2007,100 328-333. 

CAPE caffeic acid phenethyl ester DDT dichlorodiphenyltrichloroethane... 

Caffeic acid and caffeic acid phenethyl ester... 

Huang Y, Jin M, Pi R, Zhang J, Chen M, Ouyang Y et al (2012) Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurosci Lett 535 146-151... 

The active-site metal ion plays an accepted role in the catalytic function of IN, although its role in inhibition is poorly understood. The role of the metal ion in inhibition has been a topic of speculation since the first inhibitors began to appear in the literature in 1993. Early work identified some DNA-binding and DNA-intercalating molecules as IN inhibitors (18). These early inhibitors include doxorubicin (Fig. 2,1), caffeic acid phenethyl ester (CAPE, Fig. 2,2), and quercetin (Fig. 2,3). This work established, however, that there was no clear relationship between DNA-binding or DNA-intercalating activities and inhibition. It was noted that active inhibitors contained polyhydroxylated aromatic regions that... 

Ozer M.K., Parlakpinar H., Cigremis Y., Ucar M., Vardi N., Acet A. Ischemia-reperfusion leads to depletion of glutathione content and augmentation of malondialdehyde production in the rat heart from overproduction of oxidants can caffeic acid phenethyl ester (CAPE) protect the heart Mol. Cell. Biochem. 273 (2005) 169-175. 

Caffeic acid phenethyl ester, isolated from the propolis found in bee hives, has also been shown to induce apoptosis in different cell lines, probably by modulating the redox state of cells. This ester was studied under different experimental conditions and in the presence of various agents, including Bcl-2, which protects cells from oxidative stress. Indeed, this agent had a protective effect against the apoptosis induced by caffeic acid phenethyl ester [159,160]. 

Nomura M, Kaji A, Ma W, Miyamoto K, Dong Z. Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester. Mol Carcinog 2001 31 83-89. 

Caffeic Acid Phenethyl Ester (CAPE). CAPE, a phenolic compound with antioxidant properties, is an active ingredient derived from honeybee propolis (52). CAPE has antiviral, anti-inflammatory and antiproliferative properties. The compound differentially suppresses the growth of numerous human cancer cells and also inhibits tumor promoter-mediated processes in transformed cells (53,54). In transformed cells, CAPE induces apoptosis and inhibits the expression of the malignant phenotype (55,56). In addition, CAPE treatment attenuates the formation of azoxymethane-induced aberrant crypts and the activities of ornithine decarboxylase (ODC), tyrosin protein kinase, and lipoxygenase activity (57). Although the molecular basis for these multiple chemopreventive effects of CAPE is not clear, recent studies have demonstrated that CAPE is a potent and specific inhibitor of the transcription factor NF-kB (58). CAPE inhibited the activity and expression of COX-2 in the carrageenan air pouch model of inflammation as well as in TPA-treated human oral epithelial cells (59). CAPE was able to reduce neointimal formation by inhibiting NF-kB activation in a model of endothelial injury of rat carotid artery (60). 

Su, Z.Z, Lin, J., Grunberger, D., and Fisber, P.B. (1994) Growth Suppression and Toxicity Induced by Caffeic Acid Phenethyl Ester (CAPE) in T3fpe 5 Adenovirus-Transformed Rat Embryo Cells Correlate Directly with Transformation Progression, Cancer Res. 54,1865-1870. 

Frenkel, K., Wei, H., Bhimani, R., Ye, J., Zadunaisky, J.A., Huang, M.T., Ferraro, T., Conney, A.H., and Grunberger, D. (1993) Inhibition of Tumor Promoter-Mediated Processes in Mouse Skin and Bovine Lens by Caffeic Acid Phenethyl Ester, Cancer Res. 53,1255-1261. 

Natarajan, K., Singh, Burke, T., Jr., Grunberger, D., and Ag-garwal, B.B (1996) Caffeic Acid Phenethyl Ester Is a Potent and Specific Inhibitor of Activation of Nuclear Transcription Factor NF-kB, Proc. Natl. Acad. Sci. USA 93,9090-9095. 

Michaluart, R, Masfeirer, JL., Carothers,AM.,Subbaiamaiah, K., Zweifel, B.S., Koboldt, C., Mestre, J.R., Grunberger,D., Sacks, P.G., Tanabe, T., and Dannenbetg, A J. (1999) Inhibitory Effects of Caffeic Add Phenethyl Ester on the Activity and Expression of Cyclooxygenase-2 in Human Oral Epithelial Cells and in a Rat Model of Inflammation, Cancer Res. 59,2347-2352. 

Maffia, P., lanaro, A., Pisano, B., Borrelli, F., Capasso. F.. Pinto, A., and lalenti, A. (2002) Beneficial Effects of Caffeic Acid Phenethyl Ester in a Rat Model of Vascular Injury, Br. J. Pharmacol. 136,353-360. 

Quercetin and rutin increased the frequency of apoptotic cells in the male F344 rat model with chemically induced colon tumors [141]. Resveratrol enhanced upregulation of proapoptotic Smac/DIABLO protein and downregu-lated survivin in UVB exposure-mediated skin tumors [142]. Apigenin inhibits apoptosis of human prostate carcinoma tumor xenograft in athymic nude mice [143]. Caffeic acid phenethyl ester increased apoptosis and... 

NoeUcer, C. Bacher, M. Gocke, P. Wei, X. Klockgether, T. Du, Y Dodel, R. The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity. Neurosci. Lett. 2005, 383, 39-43. 

Wu, W. M., L. Lu, Y. Long et al. 2007. Free radical scavenging and antioxidative activities of caffeic acid phenethyl ester (CAPE) and its related compounds in solution and membranes A structure-activity insight. Food Chem. 105 107-115. 

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