Apoptosis inhibition

Epidermal growth factor receptor (HERl) PGFR Activation Increased cell proliferation, angiogenesis, metastasis and decreased apoptosis. Inhibition Skin rash, cancer metastasis. 

As to the functional role of sFas variants, there have been several reports based on apoptosis inhibition tests (Cl, Jl, L6, PI). According to these smdies, all sFas variants observed in normal donors are able to block the apoptosis induced by either an agonistic antibody or the natural Fas ligand in Fas-positive cells. Injection of sFas into mice significantly alters lymphocyte development (C3). Although the functional machinery remains controversial, Papoff et al. (PI) have proposed an attractive hypothetical model of structure/function relationships for the Fas molecule, as shown in Fig. 5. This model appears to be supported by the fact that all sFas variants have N-terminal ends containing the activation domain of 49 amino acids, which is required for proximal Fas ligand-mediated events. 

Arden N, Betenbaugh MJ (2004), Life and death in mammalian cell culture strategies for apoptosis inhibition, Trends Biotechnol. 22 174-180. 

Apoptosis Inhibition of apoptosis Fesus et al. [68] Anti-IL-2 antibodies inhibit Fas mediated apoptosis Algeciras-Schimnich [111]... 

Birnbaum MJ, Clem RJ, Miller LK (1994) An apoptosis-inhibiting gene from a nuclear polyhe-drosis virus encoding a polypeptide with Cys/His sequence motifs. J Virol 68 2521-2528... 

Crook NE, Clem RJ, Miller LK (1993) An apoptosis-inhibiting baculovirus gene with a zinc fingerlike motif. J Virol 67 2168-2174... 

Macrophage Suppresses cytokine production (LT) Ceii death (ET) increased apoptosis Inhibits Proi iteration (LT) Differentiation (LT) Decreases ROS TNF-a NF-xB iL-ip iRF-3 ... 

The antitumor and antimetastatic activities of EPAD may be due to the combination of inhibition of DNA synthesis in LLC cells, increase of tumor apoptosis, inhibition of tumor-induced neovascularization, and activation of CD8 T cells however, the antitumor activity of EPA ethylester may be due to the combination of inhibition of DNA synthesis in LLC cells, an increase of tumor apoptosis, inhibition of tumor-induced neovascularization, and activation of NK cells. Thus, it is suggested that the mechanisms of the antitumor and/or antimetastatic actions of EPAD and EPA ethylester involve different immune functions, and the EPA ethylester dimer and EPA hydroxy ethylester may contribute to these actions. 

Apoptosis Inhibition as a Treatment Strategy for Neurodegenerative Disease 467... 

Ligation of a death receptor does not necessarily lead to caspase-8 activation and death. TNFR1 can also activate nuclear factor-xB (NF-kB) in cells that are resistant to TNFR1 -mediated apoptosis. Inhibition of this transcription factor can thus sensitize the cells to this particular form of cell death [38]. 

Trastuzumab ADCC apoptosis inhibition of HER2 signaling with Gj arrest Loading dose of 4 mg/kg infusion followed by 2 mg/kg weekly Cardiomyopathy infusion-related toxicity... 

Dasari VR, Veeravalh KK, Tsung AJ, Gondi CS, Gujrati M, Dinh D, Rao JS (2009) Neuronal apoptosis inhibited by cord blood stem cells after spinal cord injury. J Neurotrauma 26 May 2009 [Epub ahead of print]... 

Adenine nucleotide Induces apoptosis/inhibits tumor growth MDA-MB-231 cell line/in vitro and in vivo 126... 

Vascular endothelial growth Induces apoptosis inhibits tumor growth MCE-7 cell line 132... 

Mutant K-ras gene Induces apoptosis inhibits tumor growth H441 cells line 143... 

Type I insulin-like growth factor receptor (IGF-IR) Induces apoptosis inhibits tumor growth A549 cell line xenograft model 145... 

Superoxide dismutase Inhibition of cell proliferation Inhibition of inflammation Induction of cell-cycle arrest Induction of apoptosis Inhibition of signal transduction pathways Antiangiogenesis... 

Schreiber M, Sedger L, McFaddcn G. Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition. J Virol 1997 71(3) 2171-2181. 

Wasielak M, Bogacki M 2007. Apoptosis inhibition by insulin-like growth factor (IGF)-I during in vitro maturation of bovine oocytes. J Reprod Dev 53(2) 419 6. 

Nicolaou, K.C. et al., Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methiciUin-resistant Staphylococcus aureus (MRSA), Chem. Eur. J., 7, 4296, 2001. Lee, C. et al., Two new constituents of Isodon excisus and their evaluation in an apoptosis inhibition... 

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