Caffeic acid phenethyl ester from propolis

Caffeic acid phenethyl ester, isolated from the propolis found in bee hives, has also been shown to induce apoptosis in different cell lines, probably by modulating the redox state of cells. This ester was studied under different experimental conditions and in the presence of various agents, including Bcl-2, which protects cells from oxidative stress. Indeed, this agent had a protective effect against the apoptosis induced by caffeic acid phenethyl ester [159,160]. 

Caffeic Acid Phenethyl Ester (CAPE). CAPE, a phenolic compound with antioxidant properties, is an active ingredient derived from honeybee propolis (52). CAPE has antiviral, anti-inflammatory and antiproliferative properties. The compound differentially suppresses the growth of numerous human cancer cells and also inhibits tumor promoter-mediated processes in transformed cells (53,54). In transformed cells, CAPE induces apoptosis and inhibits the expression of the malignant phenotype (55,56). In addition, CAPE treatment attenuates the formation of azoxymethane-induced aberrant crypts and the activities of ornithine decarboxylase (ODC), tyrosin protein kinase, and lipoxygenase activity (57). Although the molecular basis for these multiple chemopreventive effects of CAPE is not clear, recent studies have demonstrated that CAPE is a potent and specific inhibitor of the transcription factor NF-kB (58). CAPE inhibited the activity and expression of COX-2 in the carrageenan air pouch model of inflammation as well as in TPA-treated human oral epithelial cells (59). CAPE was able to reduce neointimal formation by inhibiting NF-kB activation in a model of endothelial injury of rat carotid artery (60). 

Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee propolis, blocks tumorigenesis in a two-stage model of mouse skin cancer that was promoted by treatment with TP A (49). The anti-cancer or antitumor promotion effects of CAPE may be based on their ability to induce apoptosis. We foimd that CAPE suppresses TPA-induced cell transformation and induced apoptosis in mouse epidermal JB6 Cl 41 cells (50). No difference in induction of apoptosis was observed between normal lymphoblasts and sphingomyelinase-deficient cell lines. Although CAPE treatment of two p53 mutant tumor cell lines, NCI-H358 and SK-OV-3, and p53 cells caused... 

Moniruzzaman, M. Kamiya, N. Goto, M. (2010). Activation and stabilization of enzymes in ionic liquids. Org, Biomol. Chem., 8,13, 2887-2899 Nagaoka, T. Banskota, A.H. Tezuka, Y. Midorikawa, K. Matsushige, K. Kadota, S. (2003). Caffeic acid phenethyl ester (cape) analogues Potent nitric oxide inhibitors from the netherlands propolis. Biol Pharm. Bull, 26,4,487-491 Nara, S.J. Harjani, J.R. Salunkhe, M.M. (2002). Lipase-catalysed transesterification in ionic liquids and organic solvents A comparative study. Tetrahedron Lett., 43, 16, 2979-2982... 

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