Induced Neurotoxicity

GuptaPK. 1976. Endosulfan-induced neurotoxicity in rats and mice. Bull Environ Contam Toxicol 15 708-713. 

Bodner A, Maroney AC, Finn JP, Ghadge G, Roos R, Miller RJ (2002) Mixed lineage kinase 3 mediates gpl20IIIB-induced neurotoxicity. J Neurochem 82 1424-1434... 

O Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL (2006) Human immunodeficiency virus (HIV)-induced neurotoxicity roles for the NMDA receptor subtypes. J Neurosci 26 981-990... 

During ischaemia, NOS is activated by calcium influx or by cytokines like tumour necrosis factor (TNF) or by lipopolysaccharide (LPS) and NO is produced in excess. It has been proposed that the excitotoxic effect of glutamate, which contributes to ischaemia-induced neuronal damage, is mediated by increased production of NO via a chain of events that includes increases in intracellular calcium (via glutamate activation of NMDA receptors), calcium activation of NOS, production of NO and peroxynitrite, and induction of lipid peroxidation. In fact, N-nitro-L-atginine, a selective inhibitor of NOS, has been shown to prevent glutamate-induced neurotoxicity in cortical cell cultures (Dawson rf /., 1991). 

Battaglia, G. Yeh, S.Y. and De Souza, E.B. MDMA-induced neurotoxicity Parameters of degeneration and recovery of brain serotonin neurons. Pharmacol Biochem Behav 29 269-274, 1988. 

FIGURE 12. Timecourse for the antagonism of MDMA-induced neurotoxicity by the 5-HT uptake inhibitor fluoxetine... 

The data deseribed above demonstrate that destruction of serotonin axons by MDMA involves the serotonin aetive uptake carrier and that administration of citalopram, a selective serotonin uptake blocker, prior to administration of MDMA, ean prevent the decreases in serotonin markers elicited by MDMA alone. These data are eonsistent with previous reports for other potent serotonin neurotoxins, demonstrating that pretreatment with serotonin uptake blockers can prevent the neurotoxic effects of parachloroamphetamine (Ross 1976 Sanders-Bush and Steranka 1978). Furthermore, it has been shown that MDMA-induced neurotoxicity can be prevented or reversed if a serotonin uptake blocker such as fluoxetine is administered no later than 12 hours after MDMA treatment (Schmidt 1986). 

Studies of MDMA-Induced Neurotoxicity in Nonhuman Primates A Basis for Evaluating Long-Term Effects in Humans... 

Cleren, C. Calingasan, N. Y. Chen, J. Beal, M. F. Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. J. Neurochem. 2005, 94, 995-1004. 

Mortensen A, Ladefoged O. 1992. Delayed neurotoxicity of trixylenyl phosphate and a trialkyl/aryl phosphate mixture, and the modulating effect of atropine on tn-ortho-to y phosphate-induced neurotoxicity. NeuroToxicology 13 347-354. 

Simple visual reaction time has proven not to be as sensitive an indicator of lead-induced neurotoxicity as some of the other behavior paradigms discussed above. Adult monkeys were tested in a simple visual... 

Poretz RD Rutgers The State Univ, New Brunswick, NJ Lead-induced neurotoxicity define a genetic factor which may cause certain individuals to be hypersusceptible to lead-induced neurobehavioral abnormalities National Institute of Environmental Health Sciences... 

Oxidative Stress A Possible Cause of METH-Induced Neurotoxicity.65... 

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