C-kit

This seems plausible, as the time at which gonocytes become invasive coincides with periods during postnatal life and puberty when Sertoli cells are producing high amounts of hormones. The malignant gonocytes overexpress c-kit so it is possible that they might proliferate in response to stimulation by stem cell factor secreted by the Sertoli cells. ... 

Consecutive reactions involving one first-order reaction and one second-order reaction, or two second-order reactions, are very difficult problems. Chien has obtained closed-form integral solutions for many of the possible kinetic schemes, but the results are too complex for straightforward application of the equations. Chien recommends that the kineticist follow the concentration of the initial reactant A, and from this information rate constant k, can be estimated. Then families of curves plotted for the various kinetic schemes, making use of an abscissa scale that is a function of c kit, are compared with concentration-time data for an intermediate or product, seeking a match that will identify the kinetic scheme and possibly lead to additional rate constant estimates. 

Sorafenib (Nexavar) TKI Raf, VEGFR2, c-Kit, PDGFR, Flt-3, FGFR1 Inhibition of kinase activity - ATP-competitive RCC... 

Ray P. Krishnamoorthy N. Ray A Emerging functions of c-kit and its ligand stem cell factor in dendritic cells regulators of T cell differentiation. Cell Cycle 2008 7 2826-2832. 

The in vivo relevance and biological importance of in vitro observations about mast cell function, as well as the contributions of mast cells towards the expression of particular biological responses (such as various models of anaphylaxis) in vivo, can be assessed using c-kit mutant mice (e.g., WBB6Fi-FCit or mice) that virtually lack mast cell populations. Mice with mutations of c-kit [6,11] or mutations that affect KIT expression [12-14] have other abnormalities of phenotype besides a mast cell deficiency. However, the mast cell deficiency of these mice can be selectively repaired by the adoptive transfer of genetically compatible, in vitro-derived... 

Kitamura Y, Go S, Hatanaka K Decrease of mast cells in W/W" mice and their increase by bone marrow transplantation. Blood 1978 52 447-452. Grimbaldeston MA, Chen CC. Piliponsky AM, Tsai M. Tam SY, Galh SJ Mast cell-deficient W-sash c-kit mutant mice as a model for investigating... 

Zsebo KM, Metcalfe DD. Geissler EN. Galli SJ Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem dS cell factor. Proc Natl Acad Sci USA 1991 88 6382. 

DW Jr, Bochner BS. Gillis S. Zsebo KM. Galli SJ, Lichtenstein LM The human recombinant c-kit 49 receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. J Immunol 1992 149 599. sO... 

In 1995, Nagata et al. [16] identified a point mutation consisting of a substitution of valine for aspartic acid in the catalytic domain of c-kit (D816V) in the peripheral blood of patients with mastocytosis and predominately myelodysplastic features. Subsequently, the same mutation was identified in adult patients with different forms of mastocytosis in tissues where mast cells are abundant, such as bone marrow, skin and spleen [17]. It is now believed that more than 90% of adults with mastocytosis have the D816V mutation, if bone marrow mononuclear cells are examined [17]. In a subset of patients, primarily those with more severe disease, the clone expands sufficiently to be detected in peripheral blood [16]. 

Detection of a codon 816 c-kit point mutation in blood, bone marrow, or lesional tissue Mast cells in the bone marrow, blood, or other lesional tissue expressing CD25 or CD2... 

Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis. N Engl J Med 1993 328 1302-1307. 

Nagata H, Worobec AS, Oh CK, et al Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA 1995 92 10560-10564. 

Sotlar K, Escribano L, Landt O, et al One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes. Am J Pathol 2003 162 737-746. 

Akin C. Brockow K. D Ambrosio C. et al Effects of tyrosine kinase inhibitor SXI571 on human mast cells bearing wild-type or mutated c-kit. Exp Hem-atol 2003 31 686-692. 

Akin C. Fumo G. Yavuz AS. et al A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood 2004 103 3222-3225. 

Semiconductors have a considerably smaller band gap (e.g. silicon 1.17 eV). Their conductivity, which is zero at low temperatures but increases to appreciable values at higher temperatures, depends greatly on the presence of impurities or, if added advertently, dopants. This makes it possible to manipulate the band gap and tune the properties of semiconductors for applications in electronic devices [C. Kit-tel. Introduction to Solid State Physics (1976), Wiley Sons, New York N. Ashcroft and N.D Mermin, Solid State Physics (1976), Saunder College]. 

Acute myeloid leukemia CD13, CD15, CD33, CD14, CD64, and C-KIT... 

Kijima T, Maulik G, Ma PC, et al. Regulation of cellular proliferation, cytoskeletal function and signal transduction through CXCR4 and c-kit in small cell lung cancer cells. Cancer Res 2002 62 6304-6311. 

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